nach oben

Journal of Neural Transmission

Erschienen in:

01.03.2014 | Psychiatry and Preclinical Psychiatric Studies - Original Article

Acute and chronic dose–response effect of methylphenidate on ventral tegmental area neurons correlated with animal behavior

verfasst von: Zachary Jones, Nachum Dafny

Erschienen in: Journal of Neural Transmission | Ausgabe 3/2014

Einloggen, um Zugang zu erhalten

Abstract

Methylphenidate (MPD) is used to treat ADHD and as a cognitive enhancement and recreationally. MPD’s effects are not fully understood. One of the sites of psychostimulant action is the ventral tegmental area (VTA). The VTA neuronal activity was recorded from freely behaving rats using a wireless system. 51 animals were divided into groups: saline, 0.6, 2.5, and 10.0 mg/kg MPD. The same repetitive MPD dose can elicit either behavioral sensitization or tolerance; thus the evaluation of the VTA neuronal activity was based on the animals’ behavioral response to chronic MPD exposure: animals exhibiting behavioral tolerance or sensitization. Acute MPD elicits dose-related increases in behavioral activity. About half of the animals exhibited behavioral sensitization or tolerance to each of the MPD doses. 361 units were recorded from the VTA and exhibited similar spike shape on experimental day 1 (ED1) and on ED10. 71, 84, and 79 % of VTA units responded to acute 0.6, 2.5, and 10.0 mg/kg MPD, respectively. The neuronal baseline activity at ED10 was significantly modified in 94, 95, and 100 % of VTA units following 0.6, 2.5 and 10.0 mg/kg MPD, respectively. Following chronic MPD exposure, 91, 98, and 100 % exhibit either electrophysiological tolerance or sensitization of 0.6, 2.6, or 10.0 mg/kg MPD, respectively. In conclusion, the chronic administration of the same dose of MPD caused some animals to exhibit behavioral sensitization and other animals to exhibit tolerance. The VTA units recorded from animals exhibiting behavioral sensitization responded significantly differently to MPD from animals that exhibited behavioral tolerance.

Algahim MF, Yang PB, Wilcox VT, Burau KD, Swann AC, Dafny N (2009) Prolonged methylphenidate treatment alters the behavioral diurnal activity pattern of adult male Sprague–Dawley rats. Pharmacol Biochem Behav 92:93–99PubMedCrossRef

Arnsten AF, Dudley AG (2005) Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: relevance to therapeutic effects in attention deficit hyperactivity disorder. Behav Brain Funct 1:2PubMedCrossRefPubMedCentral

Askenasy EP, Taber KH, Yang PB, Dafny N (2007) Methylphenidate (Ritalin): behavioral studies in the rat. Int J Neurosci 117:757–794PubMedCrossRef

Barron E, Yang PB, Swann AC, Dafny N (2009) Adolescent and adult male spontaneous hyperactive rats (SHR) respond differently to acute and chronic methylphenidate (Ritalin). Int J Neurosci 119:40–58PubMedCrossRef

Beckstead RM, Domesick VB, Nauta WJ (1979) Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res 175:191–217PubMedCrossRef

Bergheim M, Yang PB, Burau KD, Dafny N (2012) Adolescent rat circadian activity is modulated by psychostimulants. Brain Res 1431:35–45PubMedCrossRefPubMedCentral

Bonci A, Williams JT (1996) A common mechanism mediates long-term changes in synaptic transmission after chronic cocaine and morphine. Neuron 16:631–639PubMedCrossRef

Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Vaituzis AC, Dickstein DP, Sarfatti SE, Vauss YC, Snell JW, Lange N, Kaysen D, Krain AL, Ritchie GF, Rajapakse JC, Rapoport JL (1996) Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry 53:607–616PubMedCrossRef

Challman TD, Lipsky JJ (2000) Methylphenidate: its pharmacology and uses. Mayo Clin Proc 75:711–721PubMed

Chao J, Nestler EJ (2004) Molecular neurobiology of drug addiction. Annu Rev Med 55:113–132PubMedCrossRef

Chong SL, Claussen CM, Dafny N (2012) Nucleus accumbens neuronal activity in freely behaving rats is modulated following acute and chronic methylphenidate administration. Brain Res Bull 87:445–456PubMedCrossRefPubMedCentral

Claussen CM, Dafny N (2012) Acute and chronic methylphenidate modulates the neuronal activity of the caudate nucleus recorded from freely behaving rats. Brain Res Bull 87:387–396PubMedCrossRef

Dafny N (1975) Electrophysiological properties of caudate neurons following substantia nigra, motor cortex, and amygdaloid nuclear complex stimulation of the rat. Appl Neurophysiol 38:259–272PubMed

Dafny N (1980) Multiunit recording from medial basal hypothalamus following acute and chronic morphine treatment. Brain Res 190:584–592PubMedCrossRef

Dafny N (1982) The hypothalamus exhibits electrophysiologic evidence for morphine tolerance and dependence. Exp Neurol 77:66–77PubMedCrossRef

Dafny N, Terkel J (1990) Hypothalamic neuronal activity associated with onset of pseudopregnancy in the rat. Neuroendocrinology 51:459–467PubMedCrossRef

Dafny N, Yang PB (2006) The role of age, genotype, sex, and route of acute and chronic administration of methylphenidate: a review of its locomotor effects. Brain Res Bull 68:393–405PubMedCrossRef

Dietz DM, Dietz KC, Nestler EJ, Russo SJ (2009) Molecular mechanisms of psychostimulant-induced structural plasticity. Pharmacopsychiatry 42(Suppl 1):S69–S78PubMedCrossRefPubMedCentral

Fan D, Rich D, Holtzman T, Ruther P, Dalley JW, Lopez A, Rossi MA, Barter JW, Salas-Meza D, Herwik S, Holzhammer T, Morizio J, Yin HH (2011) A wireless multi-channel recording system for freely behaving mice and rats. PLoS ONE 6:e22033PubMedCrossRefPubMedCentral

Garland EJ (1998) Intranasal abuse of prescribed methylphenidate. J Am Acad Child Adolesc Psychiatry 37:1242–1243PubMedCrossRef

Gatley SJ, Volkow ND, Gifford AN, Fowler JS, Dewey SL, Ding YS, Logan J (1999) Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans. Psychopharmacology 146:93–100PubMedCrossRef

Gaytan O, Ghelani D, Martin S, Swann A, Dafny N (1996) Dose response characteristics of methylphenidate on different indices of rats’ locomotor activity at the beginning of the dark cycle. Brain Res 727:13–21PubMedCrossRef

Gaytan O, Ghelani D, Martin S, Swann A, Dafny N (1997a) Methylphenidate: diurnal effects on locomotor and stereotypic behavior in the rat. Brain Res 777:1–12PubMedCrossRef

Gaytan O, Al-rahim S, Swann A, Dafny N (1997b) Sensitization to locomotor effects of methylphenidate in the rat. Life Sci 61:L101–L107CrossRef

Gaytan O, Lewis C, Swann A, Dafny N (1999) Diurnal differences in amphetamine sensitization. Eur J Pharmacol 374:1–9PubMedCrossRef

Gaytan O, Nason R, Alagugurusamy R, Swann A, Dafny N (2000) MK-801 blocks the development of sensitization to the locomotor effects of methylphenidate. Brain Res Bull 51:485–492PubMedCrossRef

Gerasimov MR, Franceschi M, Volkow ND, Gifford A, Gatley SJ, Marsteller D, Molina PE, Dewey SL (2000) Comparison between intraperitoneal and oral methylphenidate administration: a microdialysis and locomotor activity study. J Pharmacol Exp Ther 295:51–57PubMed

Grace AA (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41:1–24PubMedCrossRef

Grace AA, Onn SP (1989) Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J Neurosci 9:3463–3481PubMed

Gronier B (2011) In vivo electrophysiological effects of methylphenidate in the prefrontal cortex: involvement of dopamine D1 and alpha 2 adrenergic receptors. Eur Neuropsychopharmacol 21:192–204PubMedCrossRef

Hyman SE, Malenka RC (2001) Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci 2:695–703PubMedCrossRef

Izenwasser S, Coy AE, Ladenheim B, Loeloff RJ, Cadet JL, French D (1999) Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaine. Eur J Pharmacol 373:187–193PubMedCrossRef

Johnson SW, North RA (1992) Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J Physiol 450:455–468PubMed

Joyce MP, Rayport S (2000) Mesoaccumbens dopamine neuron synapses reconstructed in vitro are glutamatergic. Neuroscience 99:445–456PubMedCrossRef

Kalivas PW, Duffy P (1993) Time course of extracellular dopamine and behavioral sensitization to cocaine, II. Dopamine perikarya. J Neurosci 13:276–284PubMed

Kalivas PW, Duffy P (1995) D1 receptors modulate glutamate transmission in the ventral tegmental area. J Neurosci 15:5379–5388PubMed

Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Brain Res Rev 16:223–244PubMedCrossRef

Kalivas PW, Weber B (1988) Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine. J Pharmacol Exp Ther 245:1095–1102PubMed

Kalivas PW, Duffy P, DuMars LA, Skinner C (1988) Behavioral and neurochemical effects of acute and daily cocaine administration in rats. J Pharmacol Exp Ther 245:485–492PubMed

Kalivas PW, Sorg BA, Hooks MS (1993) The pharmacology and neural circuitry of sensitization to psychostimulants. Behav Pharmacol 4:315–334PubMedCrossRef

Kalivas PW, Pierce RC, Cornish J, Sorg BA (1998) A role for sensitization in craving and relapse in cocaine addiction. J Psychopharmacol 12:49–53PubMedCrossRef

Kallman WM, Isaac W (1975) The effects of age and illumination on the dose-response curves for three stimulants. Psychopharmacologia 40:313–318PubMedCrossRef

Kauer JA (2004) Learning mechanisms in addiction: synaptic plasticity in the ventral tegmental area as a result of exposure to drugs of abuse. Annu Rev Physiol 66:447–475PubMedCrossRef

Kelz MB, Chen J, Carlezon WA Jr, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang YJ, Marotti L, Self DW, Tkatch T, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ (1999) Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 401:272–276PubMedCrossRef

Kim Y, Teylan MA, Baron M, Sands A, Nairn AC, Greengard P (2009) Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. Proc Natl Acad Sci USA 106:2915–2920PubMedCrossRef

Lacroix D, Ferron A (1988) Electrophysiological effects of methylphenidate on the coeruleo-cortical noradrenergic system in the rat. Eur J Pharmacol 149:277–285PubMedCrossRef

Lee MJ, Yang PB, Wilcox VT, Burau KD, Swann AC, Dafny N (2009) Does repetitive Ritalin injection produce long-term effects on SD female adolescent rats? Neuropharmacology 57:201–207PubMedCrossRef

Lee SS, Humphreys KL, Flory K, Liu R, Glass K (2011) Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: a meta-analytic review. Clin Psychol Rev 31:328–341PubMedCrossRefPubMedCentral

Lee SH, Seo WS, Sung HM, Choi TY, Kim SY, Choi SJ, Koo BH, Lee JH (2012) Effect of methylphenidate on sleep parameters in children with ADHD. Psychiatry Investig 9:384–390PubMedCrossRefPubMedCentral

Massello W III, Carpenter DA (1999) A fatality due to the intranasal abuse of methylphenidate (Ritalin). J Forensic Sci 44:220–221PubMed

Moratalla R, Vallejo M, Elibol B, Graybiel AM (1996) D1-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatum. NeuroReport 8:1–5PubMedCrossRef

Morris JA, Gardner MJ (1988) Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates. Br Med J (Clin Res Ed) 296:1313–1316CrossRef

Nair-Roberts RG, Chatelain-Badie SD, Benson E, White-Cooper H, Bolam JP, Ungless MA (2008) Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience 152:1024–1031PubMedCrossRefPubMedCentral

Nestler EJ (2004) Molecular mechanisms of drug addiction. Neuropharmacology 47(Suppl 1):24–32PubMedCrossRef

Nestler EJ (2005) Is there a common molecular pathway for addiction? Nat Neurosci 8:1445–1449PubMedCrossRef

Nestler EJ (2008) Review. Transcriptional mechanisms of addiction: role of DeltaFosB. Philos. Trans R Soc Lond B Biol Sci 363:3245–3255CrossRef

Papla I, Filip M, Przegalinski E (2002) Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats. Pol J Pharmacol 54:351–357PubMed

Patrick KS, Markowitz JS (1997) Pharmacology of methylphenidate, amphetamine enantiomers and pemoline in attention-deficit hyperactivity disorder. Hum Psychopharmacol Clin Exp 12:527–546CrossRef

Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, San Diego

Peakman MC, Colby C, Perrotti LI, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen MR, Stock JL, Duman RS, McNeish JD, Barrot M, Self DW, Nestler EJ, Schaeffer E (2003) Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res 970:73–86PubMedCrossRef

Pert A (1998) Neurobiological substrates underlying conditioned effects of cocaine. Adv Pharmacol 42:991–995PubMedCrossRef

Perugini M, Vezina P (1994) Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine. J Pharmacol Exp Ther 270:690–696PubMed

Pierce RC, Kalivas PW (1995) Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. J Pharmacol Exp Ther 275:1019–1029PubMed

Pierce RC, Kalivas PW (1997) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Brain Res Rev 25:192–216PubMedCrossRef

Podet A, Lee MJ, Swann AC, Dafny N (2010) Nucleus accumbens lesions modulate the effects of methylphenidate. Brain Res Bull 82:293–301PubMedCrossRef

Prieto-Gomez B, Benitez MT, Vazquez-Alvarez AM, Yang PB, Reyes VC, Dafny N (2004) Dopaminergic ventral tegmental neurons modulated by methylphenidate. Life Sci 74:1581–1592PubMedCrossRef

Prieto-Gomez B, Vazquez-Alvarez AM, Martinez-Pena JL, Reyes-Vazquez C, Yang PB, Dafny N (2005) Methylphenidate and amphetamine modulate differently the NMDA and AMPA glutamatergic transmission of dopaminergic neurons in the ventral tegmental area. Life Sci 77:635–649PubMedCrossRef

Robinson TE (1984) Behavioral sensitization: characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats. Psychopharmacology 84:466–475PubMedCrossRef

Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247–291PubMedCrossRef

Robinson TE, Kolb B (1997) Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J Neurosci 17:8491–8497PubMed

Robinson TE, Kolb B (1999) Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur J Neurosci 11:1598–1604PubMedCrossRef

Robison AJ, Nestler EJ (2011) Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 12:623–637PubMedCrossRefPubMedCentral

Salek RL, Claussen CM, Perez A, Dafny N (2012) Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats. Eur J Pharmacol 679:60–67PubMedCrossRefPubMedCentral

Scheggi S, Leggio B, Masi F, Grappi S, Gambarana C, Nanni G, Rauggi R, De Montis MG (2002) Selective modifications in the nucleus accumbens of dopamine synaptic transmission in rats exposed to chronic stress. J Neurochem 83:895–903PubMedCrossRef

Seeman P, Madras BK (1998) Anti-hyperactivity medication: methylphenidate and amphetamine. Mol Psychiatry 3:386–396PubMedCrossRef

Seeman P, Madras B (2002) Methylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: a hypothesis. Behav Brain Res 130:79–83PubMedCrossRef

Solanto MV (1998) Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav Brain Res 94:127–152PubMedCrossRef

Spanagel R, Herz A, Shippenberg TS (1992) Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 89:2046–2050PubMedCrossRef

Tang A, Wanchoo SJ, Swann AC, Dafny N (2009) Psychostimulant treatment for ADHD is modulated by prefrontal cortex manipulation. Brain Res Bull 80:353–358PubMedCrossRef

Teo SK, Stirling DI, Thomas SD, Khetani VD (2003) Neurobehavioral effects of racemic threo-methylphenidate and its d and l enantiomers in rats. Pharmacol Biochem Behav 74:747–754PubMedCrossRef

Vanderschuren LJ, Trezza V, Griffioen-Roose S, Schiepers OJ, Van LN, De Vries TJ, Schoffelmeer AN (2008) Methylphenidate disrupts social play behavior in adolescent rats. Neuropsychopharmacology 33:2946–2956PubMedCrossRefPubMedCentral

Vezina P (1993) Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat. Brain Res 605:332–337PubMedCrossRef

Volkow ND, Swanson JM (2003) Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry 160:1909–1918PubMedCrossRef

Volkow ND, Swanson JM (2008) Does childhood treatment of ADHD with stimulant medication affect substance abuse in adulthood? Am J Psychiatry 165:553–555PubMedCrossRefPubMedCentral

Volkow ND, Fowler JS, Wang G, Ding Y, Gatley SJ (2002) Mechanism of action of methylphenidate: insights from PET imaging studies. J Atten Disord 6(Suppl 1):S31–S43PubMed

Volkow ND, Wang GJ, Fowler JS, Ding YS (2005) Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1410–1415PubMedCrossRef

Volz TJ, Farnsworth SJ, Hanson GR, Fleckenstein AE (2009) Method development and validation of an in vitro model of the effects of methylphenidate on membrane-associated synaptic vesicles. J Neurosci Methods 177:177–182PubMedCrossRefPubMedCentral

Wanchoo SJ, Lee MJ, Swann AC, Dafny N (2010) Bilateral six-hydroxydopamine administration to PFC prevents the expression of behavioral sensitization to methylphenidate. Brain Res 1312:89–100PubMedCrossRef

Waterson P, Eason K, Tutt D, Dent M (2012) Using HIT to deliver integrated care for the frail elderly in the UK: current barriers and future challenges. Work 41(Suppl 1):4490–4493PubMed

White FJ, Kalivas PW (1998) Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend 51:141–153PubMedCrossRef

White SR, Yadao CM (2000) Characterization of methylphenidate exposures reported to a regional poison control center. Arch Pediatr Adolesc Med 154:1199–1203PubMedCrossRef

Wolf ME (1998) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679–720PubMedCrossRef

Yang PB, Amini B, Swann AC, Dafny N (2003) Strain differences in the behavioral responses of male rats to chronically administered methylphenidate. Brain Res 971:139–152PubMedCrossRef

Yang PB, Swann AC, Dafny N (2006a) Sensory-evoked potentials recordings from the ventral tegmental area, nucleus accumbens, prefrontal cortex, and caudate nucleus and locomotor activity are modulated in dose-response characteristics by methylphenidate. Brain Res 1073–1074:164–174PubMedCrossRef

Yang PB, Swann AC, Dafny N (2006b) Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats. Neuropharmacology 51:546–556PubMedCrossRef

Yang PB, Swann AC, Dafny N (2006c) Dose-response characteristics of methylphenidate on locomotor behavior and on sensory evoked potentials recorded from the VTA, NAc, and PFC in freely behaving rats. Behav Brain Funct 2:3PubMedCrossRefPubMedCentral

Yang PB, Swann AC, Dafny N (2006d) Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains. Brain Res Bull 71:301–310PubMedCrossRefPubMedCentral

Yang PB, Swann AC, Dafny N (2007) Chronic administration of methylphenidate produces neurophysiological and behavioral sensitization. Brain Res 1145:66–80PubMedCrossRefPubMedCentral

Yang PB, Atkins KD, Dafny N (2011) Behavioral sensitization and cross-sensitization between methylphenidate amphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in female SD rats. Eur J Pharmacol 661:72–85PubMedCrossRef

Titel: Acute and chronic dose–response effect of methylphenidate on ventral tegmental area neurons correlated with animal behavior
verfasst von: Zachary Jones
Nachum Dafny
Publikationsdatum: 01.03.2014
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 3/2014
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1101-2

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2014

Glutamate release from astrocyte cell-line GL261 via alterations in the intracellular ion environment

Neuroimmunological function in parents of children suffering from cancer

Effects of dopamine receptor blockade on the intensity-response function of electroretinographic b- and d-waves in light-adapted eyes

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese

Bacterial melanin increases electrical activity of neurons in Substantia Nigra pars compacta