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Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 6/2019

16.10.2018 | Original Article

Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus

verfasst von: Federica Romano, Paolo G. Arduino, Marina Maggiora, Elena Curmei, Valeria Manavella, Roberto Broccoletti, Mario Aimetti

Erschienen in: Clinical Oral Investigations | Ausgabe 6/2019

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Abstract

Objectives

No data are available in the literature on the extent to which the immune host-response and bacterial-elicited inflammation separately contributes to the increase in gingival crevicular fluid (GCF) levels of inflammatory biomarkers in patients affected by desquamative gingivitis (DG) secondary to oral lichen planus (OLP). The aim of this study was to investigate the effect of a structured plaque control intervention on GCF levels of MMP-1 and MMP-9 in OLP patients with DG and to compare them with those of non-OLP patients.

Materials and methods

The study population consisted of 18 unrelated Caucasian patients with DG, while 18 periodontally healthy subjects were recruited for the control group. Periodontal parameters and GCF biomarker amounts were evaluated at baseline and 2 months after a structured plaque control intervention, comprising professional oral hygiene sessions, manual toothbrushing, and interdental cleaning advice, only for DG patients. Determination of MMP-1 and MMP-9 levels was carried out by means of an enzyme-linked immunosorbent assay.

Results

Plaque control program led to improvement in all examined clinical parameters and resulted in significant decrease in GCF total amount and concentration of MMP-1 and MMP-9 in comparison to baseline (p < 0.001). However, MMP-1 and MMP-9 levels in DG patients were still significantly higher than those in the healthy control group (p < 0.01).

Conclusions

These findings would seem to support an intrinsic upregulated expression of MMPs in DG patients that is exacerbated by bacterial plaque.

Clinical relevance

The present outcomes provide further scientific grounds for the importance of strict professional oral hygiene sessions in DG patients.
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Metadaten
Titel
Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus
verfasst von
Federica Romano
Paolo G. Arduino
Marina Maggiora
Elena Curmei
Valeria Manavella
Roberto Broccoletti
Mario Aimetti
Publikationsdatum
16.10.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 6/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-018-2704-7

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