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Clinical Rheumatology

Erschienen in:

01.06.2011 | Original Article

Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese

verfasst von: Qing Zhang, Shanshan Lou, Zhaowei Meng, Xiaojun Ren

Erschienen in: Clinical Rheumatology | Ausgabe 6/2011

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Abstract

Prevalence of both metabolic syndrome (MS) and hyperuricemia are increasing. However, findings regarding their relationships are inconsistent. We aimed to explore correlations between MS and hyperuricemia in a large Chinese population, emphasizing the impacts from gender and age. Data analyses were performed in 17,762 subjects randomly recruited from Tianjin municipality in China. Hyperuricemia was defined as serum uric acid (SUA) >420 μmol/L for men, >360 μmol/L for women. MS was diagnosed by the consensus criterion released in 2009 from a joint collaboration between American Heart Association and other organizations. MS was also diagnosed by Chinese Diabetes Society (CDS) criterion. Total hyperuricemic prevalence was 12.16%, with male significantly higher than female. Total MS prevalence by consensus criterion was much higher than by CDS criterion (25.56% versus 14.09%). Correlation coefficients were much greater in women than in men. SUA was significantly positively related with body mass index and waist circumference. Generally, binary logistic regression models disclosed females with high SUA were twice likely to suffer from MS than males. Young females (≤44 years old) with hyperuricemia had the highest odd ratio of 7.857 by consensus criterion; and after further adjustment by body mass index, this odd ratio was 3.040. SUA and MS were much more closely related in females than in males. Young women with hyperuricemia had the highest risk of MS.

Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553PubMedCrossRef

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285:2486–2497CrossRef

Grundy SM, Cleeman JI, Daniels SR et al (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735–2752PubMedCrossRef

Alberti KG, Zimmet P, Shaw J (2005) The metabolic syndrome—a new worldwide definition. Lancet 366:1059–1062PubMedCrossRef

Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645PubMedCrossRef

Expert Panel on Metabolic Syndrome of Chinese Diabetes Society (2004) Recommendations on metabolic syndrome of Chinese Diabetes Society (in Chinese). Chin J Diab 12:156–161

Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356–359PubMedCrossRef

Li ZY, Xu GB, Xia TA (2006) Prevalence rate of metabolic syndrome and dyslipidemia in a large professional population in Beijing. Atherosclerosis 184:188–192PubMedCrossRef

Li Y, Stamler J, Xiao Z et al (1997) Serum uric acid and its correlates in Chinese adult populations, urban and rural, of Beijing. The PRC–USA Collaborative Study in Cardiovascular and Cardiopulmonary Epidemiology. Int J Epidemiol 26:288–296PubMedCrossRef

10.

Nan H, Qiao Q, Dong Y et al (2006) The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China. J Rheumatol 33:1346–1350PubMed

11.

Sui X, Church TS, Meriwether RA et al (2008) Uric acid and the development of metabolic syndrome in women and men. Metabolism 57:845–852PubMedCrossRef

12.

Onat A, Uyarel H, Hergenc G et al (2006) Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens 19:1055–1062PubMedCrossRef

13.

Kawamoto R, Tomita H, Oka Y et al (2006) Relationship between serum uric acid concentration, metabolic syndrome and carotid atherosclerosis. Intern Med 45:605–614PubMedCrossRef

14.

Rho YH, Woo JH, Choi SJ et al (2008) Association between serum uric acid and the Adult Treatment Panel III-defined metabolic syndrome: results from a single hospital database. Metabolism 57:71–76PubMedCrossRef

15.

Ford ES, Li C, Cook S et al (2007) Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 115:2526–2532PubMedCrossRef

16.

Niskanen LK, Laaksonen DE, Nyyssonen K et al (2004) Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med 164:1546–1551PubMedCrossRef

17.

Ioachimescu AG, Brennan DM, Hoar BM et al (2007) Serum uric acid, mortality and glucose control in patients with type 2 diabetes mellitus: a PreCIS database study. Diabet Med 24:1369–1374PubMedCrossRef

18.

Choi HK, Ford ES (2007) Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med 120:442–447PubMedCrossRef

19.

Culleton BF, Larson MG, Kannel WB et al (1999) Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 131:7–13PubMed

20.

Sakata K, Hashimoto T, Ueshima H et al (2001) Absence of an association between serum uric acid and mortality from cardiovascular disease: NIPPON DATA 80, 1980–1994. National Integrated Projects for Prospective Observation of Non-communicable Diseases and its Trend in the Aged. Eur J Epidemiol 17:461–468PubMedCrossRef

21.

Portney L, Watkins M (2000) Foundations of clinical research: applications to practice. Upper Saddle River, Prentice Hall, pp 79–110

22.

Akizuki S (1982) Serum uric acid levels among 34,000 people in Japan. Ann Rheum Dis 41:272–274PubMedCrossRef

23.

Mikkelsen WM, Dodge HJ, Valkenburg H (1965) The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia: Tecumseh, Michigan 1959–1960. Am J Med 39:242–251PubMedCrossRef

24.

Sumino H, Ichikawa S, Kanda T et al (1999) Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia. Lancet 354:650PubMed

25.

Hak AE, Choi HK (2008) Menopause, postmenopausal hormone use and serum uric acid levels in US women—the Third National Health and Nutrition Examination Survey. Arthritis Res Ther 10:R116PubMedCrossRef

26.

Anton FM, Garcia Puig J, Ramos T et al (1986) Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17 beta (E2) on the renal handling of urate. Metabolism 35:343–348PubMedCrossRef

27.

Yahyaoui R, Esteva I, Haro-Mora JJ et al (2008) Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons. J Clin Endocrinol Metab 93:2230–2233PubMedCrossRef

28.

Carr MC (2003) The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 88:2404–2411PubMedCrossRef

29.

Starcke S, Vollmer G (2006) Is there an estrogenic component in the metabolic syndrome? Genes Nutr 1:177–188PubMedCrossRef

30.

Park YW, Zhu S, Palaniappan L et al (2003) The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med 163:427–436PubMedCrossRef

31.

Sowers M, Zheng H, Tomey K et al (2007) Changes in body composition in women over 6 years at midlife: ovarian and chronological aging. J Clin Endocrinol Metab 92:895–901PubMedCrossRef

32.

Torrens JI, Sutton-Tyrrell K, Zhao X et al (2009) Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: study of Women’s Health Across the Nation. Menopause 16:257–264PubMedCrossRef

33.

Janssen I, Powell LH, Crawford S et al (2008) Menopause and the metabolic syndrome: the Study of Women’s Health Across the Nation. Arch Intern Med 168:1568–1575PubMedCrossRef

34.

Facchini F, Chen YD, Hollenbeck CB et al (1991) Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 266:3008–3011PubMedCrossRef

35.

Tsunoda S, Kamide K, Minami J et al (2002) Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. Am J Hypertens 15:697–701PubMedCrossRef

36.

Nakanishi N, Suzuki K, Kawashimo H et al (1999) Serum uric acid: correlation with biological, clinical and behavioral factors in Japanese men. J Epidemiol 9:99–106PubMed

37.

Poehlman ET, Toth MJ, Ades PA et al (1997) Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study. Eur J Clin Invest 27:322–326PubMedCrossRef

38.

Hokanson JE, Austin MA (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 3:213–219PubMedCrossRef

39.

Clark JM, Brancati FL, Diehl AM (2003) The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98:960–967PubMedCrossRef

40.

Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346:1221–1231PubMedCrossRef

41.

Marchesini G, Brizi M, Bianchi G et al (2001) Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50:1844–1850PubMedCrossRef

42.

Mellen PB, Bleyer AJ, Erlinger TP et al (2006) Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. Hypertension 48:1037–1042PubMedCrossRef

43.

Liang J, Xue Y, Zou C et al (2009) Serum uric acid and prehypertension among Chinese adults. J Hypertens 27:1761–1765PubMedCrossRef

44.

Khosla UM, Zharikov S, Finch JL et al (2005) Hyperuricemia induces endothelial dysfunction. Kidney Int 67:1739–1742PubMedCrossRef

Titel: Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese
verfasst von: Qing Zhang
Shanshan Lou
Zhaowei Meng
Xiaojun Ren
Publikationsdatum: 01.06.2011
Verlag: Springer-Verlag
Erschienen in: Clinical Rheumatology / Ausgabe 6/2011
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-010-1660-7

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