Oral non-absorbable antibiotics for colorectal surgery

Excerpt

At a recent meeting of the American Society of Colon and Rectal Surgeons, I asked several old friends about the use of oral antibiotics in antibiotic prophylaxis for elective colon and rectal surgery. I assumed I was resurrecting a dusty old memory, as it had been probably 20 years since I had prescribed oral antibiotics for one of my patients. I think the thing that stopped me from doing so was opening a surgical specimen and seeing the tablets still in the colon and so poorly digested that the numbers were still clearly legible on the intact pills. I felt that there could be no certainty with orals as to dosing and timing. I assumed that the rest of the world had also gone that way. A further change would have been an even greater effect on this practice and that is the origin of the Cochrane Collaboration. This organization has had an effect on the practice of medicine the world over that cannot be calculated. Relevant reviews of the use of antibiotics include a review that showed that mechanical bowel cleansing prior to surgery, something patients hated, was of no clinical benefit [1]. The Cochrane trauma literature also strongly supported this point, finding that fecal diversion of an injured uncleansed colon versus immediate repair could actually result in a worse clinical outcome, even if the morbidity of stoma closure were ignored [2]. Economic changes also had an effect with same day admission for surgery, further disrupting bowel preps and oral schedules. Here, in the UK, mechanical bowel cleansing is now a thing of the past, except that there are many surgeons who still give an enema before an anterior resection, though the data for this practice are lacking. In any case, with the disappearance of oral bowel cleansing, the use of oral antibiotics seemed illogical, and in many areas, the practice was ceased. And so, it was with a bit of wistful nostalgia that my colleagues talked about their fondness for oral antibiotics—the luminal versus tissue effect. …