Erschienen in:
01.10.2013 | Review Article
Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients
verfasst von:
Peng-cheng Xu, Min Chen, Ming-hui Zhao
Erschienen in:
Clinical and Experimental Nephrology
|
Ausgabe 5/2013
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Abstract
Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a common autoimmune disease in China. AAVs in the majority of Chinese patients are microscopic polyangiitis with antigenicity to myeloperoxidase. Propylthiouracil is the leading cause of drug-induced AAV. The genetic background and immunological characteristics of ANCA, such as the epitope, IgG subclass and avidity, might contribute to various clinical phenotypes of AAV.