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Esophagus

Erschienen in:

01.06.2011 | Original Article

Gender differences in clinicopathologic features and outcomes of esophageal cancer patients treated surgically

verfasst von: Naohiko Koide, Masato Kitazawa, Daisuke Komatsu, Akira Suzuki, Shinichi Miyagawa

Erschienen in: Esophagus | Ausgabe 2/2011

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Abstract

Background

We investigated the clinicopathologic features and long-term outcomes after surgery of Japanese women with esophageal cancer in comparison to those of men.

Methods

A total of 136 patients with esophageal cancer were surgically treated between 1996 and 2008 (22 [16.2%] women and 114 men). Gender differences in these patients were retrospectively investigated.

Results

Women undergoing esophagectomy for esophageal cancer showed lower frequencies of cigarette smoking (p < 0.0001) and alcohol consumption (p < 0.0001) compared to men. Preoperative co-morbidities in women were fewer than those in men (p < 0.001). Regarding the clinicopathologic features of esophageal cancer, women frequently had superficial cancer and no node metastasis (p < 0.05). Women had lower-level morbidity after surgery (p < 0.05), but no mortality after surgery was observed in men or women. Although there was no difference in other causes of death after surgery between them, recurrence/metastasis after surgery was more frequent in men than women (p < 0.05). The 5-year survival rate after surgery was higher in women than men (p < 0.05), but gender difference was not an independent prognostic factor.

Conclusions

Significant gender differences in patients with esophagectomy were observed regarding the preoperative condition, clinicopathologic features, postoperative condition, and long-term outcome after surgery. It was suggested that the more favorable outcome of women with esophageal cancer was associated with their earlier stages of esophageal cancer.

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Titel: Gender differences in clinicopathologic features and outcomes of esophageal cancer patients treated surgically
verfasst von: Naohiko Koide
Masato Kitazawa
Daisuke Komatsu
Akira Suzuki
Shinichi Miyagawa
Publikationsdatum: 01.06.2011
Verlag: Springer Japan
Erschienen in: Esophagus / Ausgabe 2/2011
Print ISSN: 1612-9059
Elektronische ISSN: 1612-9067
DOI: https://doi.org/10.1007/s10388-011-0271-y

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Abstract

Background

Methods

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Conclusions

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