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Angiogenesis

Erschienen in:

01.03.2008 | Original Paper

Hedgehog signalling in vascular development

verfasst von: Takashi Nagase, Miki Nagase, Masafumi Machida, Toshiro Fujita

Erschienen in: Angiogenesis | Ausgabe 1/2008

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Abstract

The Hedgehog family of proteins are powerful morphogens mediating embryonic development as well as adult morphogenesis and carcinogenesis. For example, excess hedgehog activity has been implicated in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. More recently, hedgehog signalling has been implicated in angiogenesis. While hedgehog signalling in adult angiogenesis may constitute a simple recapitulation of that in embryonic development, it should be appreciated that Hedgehog signalling occurs in embryonic angiogenesis in different developmental contexts. This article reviews the role of Hedgehog signalling in both embryonic and postnatal vascular development. The temporal importance of a window of hedgehog dependent angiogenesis during development is emphasised and illustrated using a whole mouse embryo culture system.

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Titel: Hedgehog signalling in vascular development
verfasst von: Takashi Nagase
Miki Nagase
Masafumi Machida
Toshiro Fujita
Publikationsdatum: 01.03.2008
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 1/2008
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-008-9105-5

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