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01.03.2016 | Original Paper

Involvement of Subcortical Brain Structures During Olfactory Stimulation in Multiple Chemical Sensitivity

verfasst von: Marco Alessandrini, Alessandro Micarelli, Agostino Chiaravalloti, Ernesto Bruno, Roberta Danieli, Mariangela Pierantozzi, Giuseppe Genovesi, Johanna Öberg, Marco Pagani, Orazio Schillaci

Erschienen in: Brain Topography | Ausgabe 2/2016

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Abstract

Multiple chemical sensitivity (MCS) patients usually react to odour compounds and the majority of neuroimaging studies assessed, especially at the cortical level, many olfactory-related correlates. The purpose of the present study was to depict sub-cortical metabolic changes during a neutral (NC) and pure (OC) olfactory stimulation by using a recently validated ¹⁸F-2-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography/computer tomography procedure in 26 MCS and 11 healthy (HC) resting subjects undergoing a battery of clinical tests. Twelve subcortical volumes of interest were identified by the automated anatomical labeling library and normalized to thalamus FDG uptake. In both groups, when comparing OC to NC, the within-subjects ANOVA demonstrated a relative decreased metabolism in bilateral putamen and hippocampus and a relative increased metabolism in bilateral amygdala, olfactory cortex (OLF), caudate and pallidum. The between-groups ANOVA demonstrated in MCS a significant higher metabolism in bilateral OLF during NC. As in HC subjects negative correlations were found in OC between FDG uptake in bilateral amygdala and hippocampus and odor pleasantness scale, the latter positively correlated with MCS subjects’ bilateral putamen FDG uptake in OC. Besides FDG uptake resemblances in both groups were found, for the first time a relative higher metabolism increase in OLF in MCS subjects at rest with respect to HC was found. When merging this aspect to the different subcortical FDG uptake correlations patterns in the two groups, the present study demonstrated to describe a peculiar metabolic index of behavioral and neurological aspects of MCS complaints.

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Titel: Involvement of Subcortical Brain Structures During Olfactory Stimulation in Multiple Chemical Sensitivity
verfasst von: Marco Alessandrini
Alessandro Micarelli
Agostino Chiaravalloti
Ernesto Bruno
Roberta Danieli
Mariangela Pierantozzi
Giuseppe Genovesi
Johanna Öberg
Marco Pagani
Orazio Schillaci
Publikationsdatum: 01.03.2016
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 2/2016
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-015-0453-3

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