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Erschienen in: Breast Cancer Research and Treatment 2/2010

01.01.2010 | Report

Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors

verfasst von: Jeremy M. Arnold, David Y. H. Choong, Ella R. Thompson, Nic Waddell, Geoffrey J. Lindeman, Jane E. Visvader, Ian G. Campbell, Georgia Chenevix-Trench, kConFab

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2010

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Abstract

Heterozygous somatic mutations of the transcription factor, GATA-3, have recently been reported in approximately 5% breast of tumors unselected for family history. We sequenced the GATA-3 gene in 55 breast tumors from women with familial breast cancer, and found seven heterozygous somatic mutations, all in non-BRCA1/2 cases in which the frequency was 22%. In contrast, we found mutations of GATA-3 in only 4% of 81 sporadic tumors analysed. It is possible that GATA3 mutations occur earlier in the evolution of BRCAx tumors, compared to BRCA1, BRCA2 or sporadic tumors, and are therefore easier to detect by direct sequencing in the presence of some stromal contamination.
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Metadaten
Titel
Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors
verfasst von
Jeremy M. Arnold
David Y. H. Choong
Ella R. Thompson
Nic Waddell
Geoffrey J. Lindeman
Jane E. Visvader
Ian G. Campbell
Georgia Chenevix-Trench
kConFab
Publikationsdatum
01.01.2010
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 2/2010
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-008-0269-x

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