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Breast Cancer Research and Treatment

Erschienen in:

19.10.2016 | Review

Circulating tumor cells in breast cancer: applications in personalized medicine

verfasst von: Jin Sun Lee, Mark Jesus M. Magbanua, John W. Park

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2016

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Abstract

Recent technological advancements in rare cell analysis have facilitated the detection of circulating tumor cells (CTCs) in the blood of patients diagnosed with breast and other types of cancers. Numerous clinical studies involving the enumeration of CTCs in breast cancer patients have unequivocally demonstrated the prognostic value of these cells. Evidence from recent molecular studies indicates that CTCs may be potential surrogate markers for systemic disease. As such, real-time assessment of therapeutic biomarkers in breast CTCs, such as the estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2), may have a tremendous impact in guiding-targeted cancer therapy. In this review, we discuss the clinical implications of CTC detection and its potential utility for personalized medicine in breast cancer.

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Titel: Circulating tumor cells in breast cancer: applications in personalized medicine
verfasst von: Jin Sun Lee
Mark Jesus M. Magbanua
John W. Park
Publikationsdatum: 19.10.2016
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 3/2016
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-016-4014-6

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Springer Medizin

Circulating tumor cells in breast cancer: applications in personalized medicine

Abstract

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Abstract

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