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25.11.2016 | Preclinical study

Triple-negative breast cancer has worse overall survival and cause-specific survival than non-triple-negative breast cancer

verfasst von: Xiaoxian Li, Jing Yang, Limin Peng, Aysegul A. Sahin, Lei Huo, Kevin C. Ward, Ruth O’Regan, Mylin A. Torres, Jane L. Meisel

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2017

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Abstract

Purpose

The current American Joint Committee on Cancer (AJCC) staging manual uses tumor size, lymph node, and metastatic status to stage breast cancer across different subtypes. We examined the prognosis of triple-negative breast cancer (TNBC) versus non-TNBC within the same stages and sub-stages to evaluate whether TNBC had worse prognosis than non-TNBC.

Methods

We reviewed the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) data and identified 158,358 patients diagnosed with breast cancer from 2010 to 2012. The overall survival (OS) time and breast cancer cause-specific survival time were compared between patients with TNBC and non-TNBC in each stage and sub-stages. The results were validated using a dataset of 2049 patients with longer follow-up from our institution.

Results

Compared with patients with non-TNBC, patients with TNBC had worse OS and breast cancer cause-specific survival time in every stage and sub-stage in univariate and multivariate analyses adjusting for age, race, tumor grade, and surgery and radiation treatments in the SEER data. The worse OS time in patients with TNBC was validated in our institutional dataset.

Conclusions

Patients with TNBC have worse survival than patients with non-TNBC. The new AJCC staging manual should consider breast cancer biomarker information.

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Titel: Triple-negative breast cancer has worse overall survival and cause-specific survival than non-triple-negative breast cancer
verfasst von: Xiaoxian Li
Jing Yang
Limin Peng
Aysegul A. Sahin
Lei Huo
Kevin C. Ward
Ruth O’Regan
Mylin A. Torres
Jane L. Meisel
Publikationsdatum: 25.11.2016
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2017
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-016-4059-6

Neu im Fachgebiet Onkologie

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Triple-negative breast cancer has worse overall survival and cause-specific survival than non-triple-negative breast cancer

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

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Methods

Results

Conclusions

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