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01.11.2007 | Original Paper

Serum uric acid and risk of cancer mortality in a large prospective male cohort

verfasst von: Alexander M. Strasak, Kilian Rapp, Wolfgang Hilbe, Willi Oberaigner, Elfriede Ruttmann, Hans Concin, Günter Diem, Karl P. Pfeiffer, Hanno Ulmer, the VHM&PP Study Group

Erschienen in: Cancer Causes & Control | Ausgabe 9/2007

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Abstract

Objective

To examine the prognostic role of serum uric acid (SUA) for cancer mortality in apparently healthy men across a wide age range.

Methods

Prospective data from a large cohort of 83,683 male Austrian adults with a median follow-up of 13.6 years was analyzed. Cox proportional hazards models, adjusted for established risk factors, were calculated to evaluate SUA as a predictive marker for fatal cancer events.

Results

High SUA (>6.71 mg/dl) was independently associated with increased risk of mortality from all cancers, showing a clear dose–response relationship (p for trend < 0.0001); the adjusted hazard ratio for the highest versus lowest quintile of SUA was 1.41 (1.22–1.62). In subgroup analyses this hazard ratio increased to 1.53 (1.29–1.80) for participants aged <65 years. When considering the time interval between baseline SUA measurement and subsequent death, SUA levels were more predictive for “late deaths”, occurring 10 or more years after screening (HR 1.65 [1.35–2.03], p < 0.0001), in comparison to deaths within 10 years after SUA measurement. In cancer site-specific analyses, SUA was significantly associated with deaths from malignant neoplasms of digestive organs (p = 0.03) and respiratory system and intrathoracic organs (p < 0.0001). Elevated SUA was further independently related to an increased risk of all-cause mortality (p < 0.0001).

Conclusions

Our results are contrary to the proposed antioxidant, inhibitory effect of SUA against cancer and rather suggest high SUA to be a valuable long-term surrogate parameter, indicative for a life-style at increased risk for the development of cancer.

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Titel: Serum uric acid and risk of cancer mortality in a large prospective male cohort
verfasst von: Alexander M. Strasak
Kilian Rapp
Wolfgang Hilbe
Willi Oberaigner
Elfriede Ruttmann
Hans Concin
Günter Diem
Karl P. Pfeiffer
Hanno Ulmer
the VHM&PP Study Group
Publikationsdatum: 01.11.2007
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 9/2007
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-007-9043-3

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Serum uric acid and risk of cancer mortality in a large prospective male cohort