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Digestive Diseases and Sciences

Erschienen in:

01.02.2009 | Original Article

Study of the Association Between Polymorphisms of the COL1A1 Gene and HBV-Related Liver Cirrhosis in Chinese Patients

verfasst von: Yun-Peng Zhao, Hao Wang, Meng Fang, Qiang Ji, Zai-Xing Yang, Chun-Fang Gao

Erschienen in: Digestive Diseases and Sciences | Ausgabe 2/2009

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Abstract

To investigate the association between polymorphisms of the COL1A1 gene and liver cirrhosis. A total of 111 liver cirrhotic patients and 95 matched controls were recruited. Polymorphisms −1997T>G, −1663 ins/del T and −1363C>G of the COL1A1 gene were detected by direct sequencing. The activities of the putative promoters containing these polymorphisms were analyzed by means of the reporter gene system. No polymorphism at −1663 ins/del T was observed in any subject. Linkage disequilibrium was shown between −1997T>G and −1363C>G. The frequency of haplotype −1997T/−1363C was significantly higher in patients than that in controls. The putative promoters containing −1997T/−1363C resulted in higher reporter gene activity in LX-2. Strong transcriptional inhibition by IFNγ was shown in both cells. The T allele at −1997 of COL1A1 is crucial to the increased transcriptional activity. COL1A1 gene polymorphism might be associated with liver fibrogenesis.

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Titel: Study of the Association Between Polymorphisms of the COL1A1 Gene and HBV-Related Liver Cirrhosis in Chinese Patients
verfasst von: Yun-Peng Zhao
Hao Wang
Meng Fang
Qiang Ji
Zai-Xing Yang
Chun-Fang Gao
Publikationsdatum: 01.02.2009
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 2/2009
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0340-9

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Study of the Association Between Polymorphisms of the COL1A1 Gene and HBV-Related Liver Cirrhosis in Chinese Patients

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