Erschienen in:
01.10.2009 | Original Article
What Are the Clinical Implications of Nodular Gastritis? Clues from Histopathology
verfasst von:
Cenk Sokmensuer, Ibrahim Koral Onal, Ozgur Yeniova, Osman Ersoy, Musa Aydinli, Ozlem Yonem, Ozgur Harmanci, Eda Demir Onal, Gulcin Altinok, Figen Batman, Yusuf Bayraktar
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 10/2009
Einloggen, um Zugang zu erhalten
Abstract
There is no widely accepted histopathological definition for nodular gastritis. In this study we aim to uncover the pathologic entity responsible for the nodular appearance and to find clues about the clinical implications of nodular gastritis. Antral biopsy specimens of 160 patients with nodular gastritis and 133 patients without nodular gastritis were examined by an experienced pathologist for dysplasia, foveolar hyperplasia, inflammatory activity, intraepithelial lymphocytosis, intestinal metaplasia, and lymphoid follicle/aggregate formation, and comparative analysis was performed between the two groups of patients. The presence of intraepithelial lymphocytosis was more frequent in patients with nodular gastritis (P < 0.05). There was no difference between the two groups regarding the other pathological features such as presence of dysplasia, inflammatory activity, intestinal metaplasia, lymphoid hyperplasia, and Helicobacter pylori (H. pylori) infection. Increase of intraepithelial lymphocytes may contribute to formation of macroscopical nodules in this peculiar type of gastritis. Nodular gastritis would not indicate a new therapeutic approach in addition to the current measures for Helicobacter pylori infection.