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Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 11/2015

01.11.2015 | Review

Cirrhotic Multiorgan Syndrome

verfasst von: Søren Møller, Flemming Bendtsen

Erschienen in: Digestive Diseases and Sciences | Ausgabe 11/2015

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Abstract

Patients with cirrhosis and portal hypertension are at an increased risk of the development of circulatory dysfunction that may potentially result in multiple organ failure. Apart from the liver, this may involve the heart, lungs, kidneys, the immune system, the adrenal glands, and other organ systems. As the disease progresses, the circulation becomes hyperdynamic, and signs of cardiac, pulmonary, and renal dysfunction are observed, in addition to reduced survival. Infections and an altered cardiac function known as cirrhotic cardiomyopathy may be precipitators for the development of other complications such as hepatorenal syndrome. In patients with chronic organ dysfunction, various precipitating events may induce an acute-on-chronic renal failure and acute-on-chronic liver failure that negatively affect the prognosis. Future research on the pathophysiologic mechanisms of the complications and the precipitating factors is essential to understand the basics of the treatment of these challenging conditions. The aim of the present review is to focus on the development and precipitating factors of various organ failures in patients with decompensated cirrhosis.
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Metadaten
Titel
Cirrhotic Multiorgan Syndrome
verfasst von
Søren Møller
Flemming Bendtsen
Publikationsdatum
01.11.2015
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 11/2015
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-015-3752-3

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