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Erschienen in: Digestive Diseases and Sciences 8/2017

18.05.2017 | Original Article

Primary Care and Hepatology Provider–Perceived Barriers to and Facilitators of Hepatitis C Treatment Candidacy and Adherence

verfasst von: Shari S. Rogal, Rory McCarthy, Andrea Reid, Keri L. Rodriguez, Linda Calgaro, Krupa Patel, Molly Daley, Naudia L. Jonassaint, Susan L. Zickmund

Erschienen in: Digestive Diseases and Sciences | Ausgabe 8/2017

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Abstract

Background

Provider perceptions regarding barriers to and facilitators of hepatitis C (HCV) treatment initiation and adherence have not been fully evaluated in the interferon-free treatment era. New treatments have provided opportunities for non-specialists to treat HCV, underscoring the importance of understanding primary care provider (PCP) and specialist perspectives.

Methods

Based on qualitative sampling principles, 12 PCPs and 12 hepatology providers (HPs) from the VA Pittsburgh Healthcare System completed audio-recorded semi-structured interviews. Qualitative analysts coded perceived barriers and facilitators from the interviews with 100% double coding. Codes were thematized and analyzed using Atlas.ti.

Results

Key barriers to treatment described by HPs and PCPs included patients’ substance use disorders, mental health, transportation availability, history of non-adherence, and concern about side effects. PCPs also focused on medication cost as a system-based barrier. The main facilitators of treatment initiation and adherence described by both HPs and PCPs were provider education and encouragement. HPs focused almost exclusively on provider-based facilitators, while PCPs noted patient-based facilitators including past adherence, media exposure to information about HCV medications, a desire to clear the virus, and positive feedback regarding treatment response.

Conclusions

Providers generally focused on perceived patient-level barriers to HCV treatment initiation and adherence, as well as provider-level facilitators; PCPs additionally noted patient preferences and system-level issues that guide decision making regarding treatment initiation. While HPs focused almost exclusively on provider-level facilitators, PCPs additionally focused on patient-level facilitators of treatment. These data provide novel insights and suggest focusing on patient, provider, and system-level strategies to further improve HCV treatment initiation and adherence.
Literatur
1.
2.
Zurück zum Zitat Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013;57:1333–1342.CrossRefPubMed Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013;57:1333–1342.CrossRefPubMed
3.
Zurück zum Zitat Younossi ZM, Stepanova M, Afdhal N, et al. Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir. J Hepatol. 2015;63:337–345.CrossRefPubMed Younossi ZM, Stepanova M, Afdhal N, et al. Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir. J Hepatol. 2015;63:337–345.CrossRefPubMed
4.
6.
Zurück zum Zitat Bini EJ, Brau N, Currie S, et al. Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infection. Am J Gastroenterol. 2005;100:1772–1779.CrossRefPubMed Bini EJ, Brau N, Currie S, et al. Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infection. Am J Gastroenterol. 2005;100:1772–1779.CrossRefPubMed
7.
Zurück zum Zitat Butt AA, McGinnis K, Skanderson M, Justice AC. A comparison of treatment eligibility for hepatitis C virus in HCV-monoinfected versus HCV/HIV-coinfected persons in electronically retrieved cohort of HCV-infected veterans. AIDS Res Hum Retroviruses. 2011;27:973–979.CrossRefPubMedPubMedCentral Butt AA, McGinnis K, Skanderson M, Justice AC. A comparison of treatment eligibility for hepatitis C virus in HCV-monoinfected versus HCV/HIV-coinfected persons in electronically retrieved cohort of HCV-infected veterans. AIDS Res Hum Retroviruses. 2011;27:973–979.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Kramer JR, Kanwal F, Richardson P, Giordano TP, Petersen LA, El-Serag HB. Importance of patient, provider, and facility predictors of hepatitis C virus treatment in veterans: A national study. Am J Gastroenterol. 2011;106:483–491.CrossRefPubMed Kramer JR, Kanwal F, Richardson P, Giordano TP, Petersen LA, El-Serag HB. Importance of patient, provider, and facility predictors of hepatitis C virus treatment in veterans: A national study. Am J Gastroenterol. 2011;106:483–491.CrossRefPubMed
9.
Zurück zum Zitat Cheung RC, Currie S, Shen H, et al. Chronic hepatitis C in Latinos: Natural history, treatment eligibility, acceptance, and outcomes. Am J Gastroenterol. 2005;100:2186–2193.CrossRefPubMed Cheung RC, Currie S, Shen H, et al. Chronic hepatitis C in Latinos: Natural history, treatment eligibility, acceptance, and outcomes. Am J Gastroenterol. 2005;100:2186–2193.CrossRefPubMed
10.
Zurück zum Zitat Backus LI, Belperio PS, Loomis TP, Mole LA. Impact of race/ethnicity and gender on HCV screening and prevalence among US veterans in department of veterans affairs care. Am J Public Health. 2014;104:555–561.CrossRef Backus LI, Belperio PS, Loomis TP, Mole LA. Impact of race/ethnicity and gender on HCV screening and prevalence among US veterans in department of veterans affairs care. Am J Public Health. 2014;104:555–561.CrossRef
11.
Zurück zum Zitat Rousseau CM, Ioannou GN, Todd-Stenberg JA, et al. Racial differences in the evaluation and treatment of hepatitis C among veterans: A retrospective cohort study. Am J Public Health. 2008;98:846–852.CrossRefPubMedPubMedCentral Rousseau CM, Ioannou GN, Todd-Stenberg JA, et al. Racial differences in the evaluation and treatment of hepatitis C among veterans: A retrospective cohort study. Am J Public Health. 2008;98:846–852.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Myles A, Mugford GJ, Zhao J, Krahn M, Wang PP. Physicians’ attitudes and practice toward treating injection drug users with hepatitis C: Results from a national specialist survey in Canada. Can J Gastroenterol. 2011;25:135–139.CrossRefPubMedPubMedCentral Myles A, Mugford GJ, Zhao J, Krahn M, Wang PP. Physicians’ attitudes and practice toward treating injection drug users with hepatitis C: Results from a national specialist survey in Canada. Can J Gastroenterol. 2011;25:135–139.CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Swan D, Long J, Carr O, et al. Barriers to and facilitators of hepatitis C testing, management, and treatment among current and former injecting drug users: A qualitative exploration. AIDS Patient Care STDs. 2010;24:753–762.CrossRefPubMed Swan D, Long J, Carr O, et al. Barriers to and facilitators of hepatitis C testing, management, and treatment among current and former injecting drug users: A qualitative exploration. AIDS Patient Care STDs. 2010;24:753–762.CrossRefPubMed
14.
Zurück zum Zitat Ho SB, Groessl E, Dollarhide A, Robinson S, Kravetz D, Dieperink E. Management of chronic hepatitis C in veterans: The potential of integrated care models. Am J Gastroenterol. 2008;103:1810–1823.CrossRefPubMed Ho SB, Groessl E, Dollarhide A, Robinson S, Kravetz D, Dieperink E. Management of chronic hepatitis C in veterans: The potential of integrated care models. Am J Gastroenterol. 2008;103:1810–1823.CrossRefPubMed
15.
Zurück zum Zitat Chainuvati S, Khalid SK, Kancir S, et al. Comparison of hepatitis C treatment patterns in patients with and without psychiatric and/or substance use disorders. J Viral Hepatitis. 2006;13:235–241.CrossRef Chainuvati S, Khalid SK, Kancir S, et al. Comparison of hepatitis C treatment patterns in patients with and without psychiatric and/or substance use disorders. J Viral Hepatitis. 2006;13:235–241.CrossRef
16.
Zurück zum Zitat Sylvestre DL, Clements BJ. Adherence to hepatitis C treatment in recovering heroin users maintained on methadone. Eur J Gastroenterol Hepatol. 2007;19:741–747.CrossRefPubMed Sylvestre DL, Clements BJ. Adherence to hepatitis C treatment in recovering heroin users maintained on methadone. Eur J Gastroenterol Hepatol. 2007;19:741–747.CrossRefPubMed
17.
Zurück zum Zitat Aspinall EJ, Corson S, Doyle JS, et al. Treatment of hepatitis C virus infection among people who are actively injecting drugs: A systematic review and meta-analysis. Clin Infect Dis. 2013;57:S80–S89.CrossRefPubMed Aspinall EJ, Corson S, Doyle JS, et al. Treatment of hepatitis C virus infection among people who are actively injecting drugs: A systematic review and meta-analysis. Clin Infect Dis. 2013;57:S80–S89.CrossRefPubMed
18.
Zurück zum Zitat Arain A, Robaeys G. Eligibility of persons who inject drugs for treatment of hepatitis C virus infection. World J Gastroenterol. 2014;20:12722–12733.CrossRefPubMedPubMedCentral Arain A, Robaeys G. Eligibility of persons who inject drugs for treatment of hepatitis C virus infection. World J Gastroenterol. 2014;20:12722–12733.CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Grebely J, Robaeys G, Bruggmann P, et al. Recommendations for the management of hepatitis C virus infection among people who inject drugs. Int J Drug Policy. 2015;26:1028–1038.CrossRefPubMed Grebely J, Robaeys G, Bruggmann P, et al. Recommendations for the management of hepatitis C virus infection among people who inject drugs. Int J Drug Policy. 2015;26:1028–1038.CrossRefPubMed
20.
Zurück zum Zitat Afdhal N, Zeuzem S, Kwo P, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370:1889–1898.CrossRefPubMed Afdhal N, Zeuzem S, Kwo P, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370:1889–1898.CrossRefPubMed
21.
Zurück zum Zitat Yau AH, Yoshida EM. Hepatitis C drugs: The end of the pegylated interferon era and the emergence of all-oral interferon-free antiviral regimens: A concise review. Can J Gastroenterol Hepatol. 2014;28:445–451.CrossRefPubMedPubMedCentral Yau AH, Yoshida EM. Hepatitis C drugs: The end of the pegylated interferon era and the emergence of all-oral interferon-free antiviral regimens: A concise review. Can J Gastroenterol Hepatol. 2014;28:445–451.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Belpario P. VA HCV care delivery in FY15/choice first update. American Association for the Study of Liver Disease Annual Meeting, VA Hot Topics; 2015. Belpario P. VA HCV care delivery in FY15/choice first update. American Association for the Study of Liver Disease Annual Meeting, VA Hot Topics; 2015.
23.
Zurück zum Zitat Creswell JW. Qualitative Inquiry and Research Design: Choosing Among Five Traditions. Thousand Oaks: Sage; 1998. Creswell JW. Qualitative Inquiry and Research Design: Choosing Among Five Traditions. Thousand Oaks: Sage; 1998.
24.
Zurück zum Zitat Crabtree BF, Miller WL, eds. Doing Qualitative Research. London: Sage Press; 1992. Crabtree BF, Miller WL, eds. Doing Qualitative Research. London: Sage Press; 1992.
25.
Zurück zum Zitat Cohen J. A coefficient of agreement for nominal scales: An asymmetric version of kappa. Educ Psychol Meas. 1960;20:37–46.CrossRef Cohen J. A coefficient of agreement for nominal scales: An asymmetric version of kappa. Educ Psychol Meas. 1960;20:37–46.CrossRef
26.
Zurück zum Zitat Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–174.CrossRefPubMed Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–174.CrossRefPubMed
29.
30.
Zurück zum Zitat Sublette VA, Smith SK, George J, McCaffery K, Douglas MW. Listening to both sides: A qualitative comparison between patients with hepatitis C and their healthcare professionals’ perceptions of the facilitators and barriers to hepatitis C treatment adherence and completion. J Health Psychol. 2016. doi:10.1177/1359105316669858. Sublette VA, Smith SK, George J, McCaffery K, Douglas MW. Listening to both sides: A qualitative comparison between patients with hepatitis C and their healthcare professionals’ perceptions of the facilitators and barriers to hepatitis C treatment adherence and completion. J Health Psychol. 2016. doi:10.​1177/​1359105316669858​.
31.
Zurück zum Zitat Bird GC, Cannon CP, Kennison RH. Results of a survey assessing provider beliefs of adherence barriers to antiplatelet medications. Crit Pathw Cardiol. 2011;10:134–141.CrossRefPubMed Bird GC, Cannon CP, Kennison RH. Results of a survey assessing provider beliefs of adherence barriers to antiplatelet medications. Crit Pathw Cardiol. 2011;10:134–141.CrossRefPubMed
33.
Zurück zum Zitat Bogart LM, Kelly JA, Catz SL, Sosman JM. Impact of medical and nonmedical factors on physician decision making for HIV/AIDS antiretroviral treatment. J Acquir Immune Defic Syndr. 2000;23:396–404.CrossRefPubMed Bogart LM, Kelly JA, Catz SL, Sosman JM. Impact of medical and nonmedical factors on physician decision making for HIV/AIDS antiretroviral treatment. J Acquir Immune Defic Syndr. 2000;23:396–404.CrossRefPubMed
34.
Zurück zum Zitat Lee L, Rand CS, Ellen JM, Agwu AL. Factors informing HIV providers’ decisions to start antiretroviral therapy for young people living with behaviorally acquired HIV. J Adolesc Health. 2014;55:358–365.CrossRefPubMedPubMedCentral Lee L, Rand CS, Ellen JM, Agwu AL. Factors informing HIV providers’ decisions to start antiretroviral therapy for young people living with behaviorally acquired HIV. J Adolesc Health. 2014;55:358–365.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Spector AY, Remien RH, Tross S. PrEP in substance abuse treatment: A qualitative study of treatment provider perspectives. Subst Abuse Treat Prev Policy. 2015;10:1.CrossRefPubMedPubMedCentral Spector AY, Remien RH, Tross S. PrEP in substance abuse treatment: A qualitative study of treatment provider perspectives. Subst Abuse Treat Prev Policy. 2015;10:1.CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Bangsberg DR, Hecht FM, Clague H, et al. Provider assessment of adherence to HIV antiretroviral therapy. J Acquir Immune Defic Syndr. 2001;26:435–442.CrossRefPubMed Bangsberg DR, Hecht FM, Clague H, et al. Provider assessment of adherence to HIV antiretroviral therapy. J Acquir Immune Defic Syndr. 2001;26:435–442.CrossRefPubMed
37.
Zurück zum Zitat Gilbert JR, Evans CE, Haynes RB, Tugwell P. Predicting compliance with a regimen of digoxin therapy in family practice. Can Med Assoc J. 1980;123:119–122.PubMedPubMedCentral Gilbert JR, Evans CE, Haynes RB, Tugwell P. Predicting compliance with a regimen of digoxin therapy in family practice. Can Med Assoc J. 1980;123:119–122.PubMedPubMedCentral
38.
Zurück zum Zitat Taylor J, Carr-Lopez S, Robinson A, et al. Determinants of treatment eligibility in veterans with hepatitis C viral infection. Clin Ther. 2016;39:130–137.CrossRefPubMed Taylor J, Carr-Lopez S, Robinson A, et al. Determinants of treatment eligibility in veterans with hepatitis C viral infection. Clin Ther. 2016;39:130–137.CrossRefPubMed
39.
Zurück zum Zitat Tsui JI, Williams EC, Green PK, Berry K, Su F, Ioannou GN. Alcohol use and hepatitis C virus treatment outcomes among patients receiving direct antiviral agents. Drug Alcohol Depend. 2016;169:101–109.CrossRefPubMed Tsui JI, Williams EC, Green PK, Berry K, Su F, Ioannou GN. Alcohol use and hepatitis C virus treatment outcomes among patients receiving direct antiviral agents. Drug Alcohol Depend. 2016;169:101–109.CrossRefPubMed
40.
Zurück zum Zitat Grebely J, Alavi M, Micallef M, et al. Treatment for hepatitis C virus infection among people who inject drugs attending opioid substitution treatment and community health clinics: The ETHOS study. Addiction. 2016;111:311–319.CrossRefPubMed Grebely J, Alavi M, Micallef M, et al. Treatment for hepatitis C virus infection among people who inject drugs attending opioid substitution treatment and community health clinics: The ETHOS study. Addiction. 2016;111:311–319.CrossRefPubMed
41.
Zurück zum Zitat Hayashi K, Wood E, Kerr T, et al. Factors associated with optimal pharmacy refill adherence for antiretroviral medications and plasma HIV RNA non-detectability among HIV-positive crack cocaine users: A prospective cohort study. BMC Infect Dis. 2016;16:455.CrossRefPubMedPubMedCentral Hayashi K, Wood E, Kerr T, et al. Factors associated with optimal pharmacy refill adherence for antiretroviral medications and plasma HIV RNA non-detectability among HIV-positive crack cocaine users: A prospective cohort study. BMC Infect Dis. 2016;16:455.CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Azar P, Wood E, Nguyen P, et al. Drug use patterns associated with risk of non-adherence to antiretroviral therapy among HIV-positive illicit drug users in a Canadian setting: A longitudinal analysis. BMC Infect Dis. 2015;15:193.CrossRefPubMedPubMedCentral Azar P, Wood E, Nguyen P, et al. Drug use patterns associated with risk of non-adherence to antiretroviral therapy among HIV-positive illicit drug users in a Canadian setting: A longitudinal analysis. BMC Infect Dis. 2015;15:193.CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Mindachew M, Deribew A, Memiah P, Biadgilign S. Perceived barriers to the implementation of Isoniazid preventive therapy for people living with HIV in resource constrained settings: A qualitative study. Pan Afr Med J. 2014;17:26.CrossRefPubMedPubMedCentral Mindachew M, Deribew A, Memiah P, Biadgilign S. Perceived barriers to the implementation of Isoniazid preventive therapy for people living with HIV in resource constrained settings: A qualitative study. Pan Afr Med J. 2014;17:26.CrossRefPubMedPubMedCentral
44.
Zurück zum Zitat Thompson VV, Ragland KE, Hall CS, Morgan M, Bangsberg DR. Provider assessment of eligibility for hepatitis C treatment in HIV-infected homeless and marginally housed persons. AIDS. 2005;19:S208–S214.CrossRefPubMed Thompson VV, Ragland KE, Hall CS, Morgan M, Bangsberg DR. Provider assessment of eligibility for hepatitis C treatment in HIV-infected homeless and marginally housed persons. AIDS. 2005;19:S208–S214.CrossRefPubMed
45.
Zurück zum Zitat Stewart BJ, Mikocka-Walus AA, Harley H, Andrews JM. Help-seeking and coping with the psychosocial burden of chronic hepatitis C: A qualitative study of patient, hepatologist, and counsellor perspectives. Int J Nurs Stud. 2012;49:560–569.CrossRefPubMed Stewart BJ, Mikocka-Walus AA, Harley H, Andrews JM. Help-seeking and coping with the psychosocial burden of chronic hepatitis C: A qualitative study of patient, hepatologist, and counsellor perspectives. Int J Nurs Stud. 2012;49:560–569.CrossRefPubMed
47.
Zurück zum Zitat Rongey C, Asch S, Knight SJ. Access to care for vulnerable veterans with hepatitis C: A hybrid conceptual framework and a case study to guide translation. Transl Behav Med. 2011;1:644–651.CrossRefPubMedPubMedCentral Rongey C, Asch S, Knight SJ. Access to care for vulnerable veterans with hepatitis C: A hybrid conceptual framework and a case study to guide translation. Transl Behav Med. 2011;1:644–651.CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Park-Wyllie LY, Kam D, Bayoumi AM. The adherence support gap: The ‘ideal’ versus ‘reality’ of antiretroviral adherence support provided by HIV health providers in clinical practice. Ann Pharmacother. 2009;43:1036–1044.CrossRefPubMed Park-Wyllie LY, Kam D, Bayoumi AM. The adherence support gap: The ‘ideal’ versus ‘reality’ of antiretroviral adherence support provided by HIV health providers in clinical practice. Ann Pharmacother. 2009;43:1036–1044.CrossRefPubMed
Metadaten
Titel
Primary Care and Hepatology Provider–Perceived Barriers to and Facilitators of Hepatitis C Treatment Candidacy and Adherence
verfasst von
Shari S. Rogal
Rory McCarthy
Andrea Reid
Keri L. Rodriguez
Linda Calgaro
Krupa Patel
Molly Daley
Naudia L. Jonassaint
Susan L. Zickmund
Publikationsdatum
18.05.2017
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 8/2017
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4608-9

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