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Erschienen in: European Journal of Epidemiology 4/2019

12.02.2019 | COMMENTARY

Unreformed nutritional epidemiology: a lamp post in the dark forest

verfasst von: John P. A. Ioannidis

Erschienen in: European Journal of Epidemiology | Ausgabe 4/2019

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Excerpt

Giovannucci disagrees [1] that reform is needed [24] in nutritional epidemiology. He argues that nutritional effects are large, and that traditional means of measuring exposure and handling confounding secure reliable answers. Complexity is manageable through readily definable diet patterns, important questions are obvious, we pretty much know the answers. Analyses demonstrate the wisdom of our hypotheses. Giovannucci eloquently admits searching under the lamp post, confident that whatever is worth finding is right there. …
Literatur
2.
Zurück zum Zitat Trepanowski JF, Ioannidis PA. Limiting dependence on nonrandomized studies and improving randomized trials in human nutrition research: why and how. Adv Nutr. 2018;9:367–77.CrossRefPubMedPubMedCentral Trepanowski JF, Ioannidis PA. Limiting dependence on nonrandomized studies and improving randomized trials in human nutrition research: why and how. Adv Nutr. 2018;9:367–77.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Ioannidis JP. The challenge of reforming nutritional epidemiologic research. JAMA. 2018;320:969–70.CrossRefPubMed Ioannidis JP. The challenge of reforming nutritional epidemiologic research. JAMA. 2018;320:969–70.CrossRefPubMed
5.
Zurück zum Zitat Young SS, Karr A. Deming, data and observational studies. Significance. 2011;8(3):116–20.CrossRef Young SS, Karr A. Deming, data and observational studies. Significance. 2011;8(3):116–20.CrossRef
6.
Zurück zum Zitat Jenkins DJA, Spence JD, Giovannucci EL, Kim YI, Josse R, Vieth R, Blanco Mejia S, Viguiliouk E, Nishi S, Sahye-Pudaruth S, Paquette M, Patel D, Mitchell S, Kavanagh M, Tsirakis T, Bachiri L, Maran A, Umatheva N, McKay T, Trinidad G, Bernstein D, Chowdhury A, Correa-Betanzo J, Del Principe G, Hajizadeh A, Jayaraman R, Jenkins A, Jenkins W, Kalaichandran R, Kirupaharan G, Manisekaran P, Qutta T, Shahid R, Silver A, Villegas C, White J, Kendall CWC, Pichika SC, Sievenpiper JL. Supplemental vitamins and minerals for CVD prevention and treatment. J Am Coll Cardiol. 2018;71(22):2570–84.CrossRefPubMed Jenkins DJA, Spence JD, Giovannucci EL, Kim YI, Josse R, Vieth R, Blanco Mejia S, Viguiliouk E, Nishi S, Sahye-Pudaruth S, Paquette M, Patel D, Mitchell S, Kavanagh M, Tsirakis T, Bachiri L, Maran A, Umatheva N, McKay T, Trinidad G, Bernstein D, Chowdhury A, Correa-Betanzo J, Del Principe G, Hajizadeh A, Jayaraman R, Jenkins A, Jenkins W, Kalaichandran R, Kirupaharan G, Manisekaran P, Qutta T, Shahid R, Silver A, Villegas C, White J, Kendall CWC, Pichika SC, Sievenpiper JL. Supplemental vitamins and minerals for CVD prevention and treatment. J Am Coll Cardiol. 2018;71(22):2570–84.CrossRefPubMed
7.
Zurück zum Zitat Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF, Tang G, Wang B, Chen D, He M, Fu J, Cai Y, Shi X, Zhang Y, Cui Y, Sun N, Li X, Cheng X, Wang J, Yang X, Yang T, Xiao C, Zhao G, Dong Q, Zhu D, Wang X, Ge J, Zhao L, Hu D, Liu L, Hou FF, CSPPT Investigators. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. 2015;313(13):1325–35.CrossRefPubMed Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF, Tang G, Wang B, Chen D, He M, Fu J, Cai Y, Shi X, Zhang Y, Cui Y, Sun N, Li X, Cheng X, Wang J, Yang X, Yang T, Xiao C, Zhao G, Dong Q, Zhu D, Wang X, Ge J, Zhao L, Hu D, Liu L, Hou FF, CSPPT Investigators. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. 2015;313(13):1325–35.CrossRefPubMed
8.
Zurück zum Zitat Baron JA, Barry EL, Mott LA, et al. A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med. 2015;373:1519–30.CrossRefPubMedPubMedCentral Baron JA, Barry EL, Mott LA, et al. A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med. 2015;373:1519–30.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F, GEFOS/GENOMOS consortium and the 23andMe research team. Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study. BMJ. 2018;362:k3225.CrossRefPubMedPubMedCentral Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F, GEFOS/GENOMOS consortium and the 23andMe research team. Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study. BMJ. 2018;362:k3225.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Risk and Prevention Study Collaborative Group, Roncaglioni MC, Tombesi M, Avanzini F, Barlera S, Caimi V, Longoni P, Marzona I, Milani V, Silletta MG, Tognoni G, Marchioli R. n-3 fatty acids in patients with multiple cardiovascular risk factors. N Engl J Med. 2013;368(19):1800–8.CrossRef Risk and Prevention Study Collaborative Group, Roncaglioni MC, Tombesi M, Avanzini F, Barlera S, Caimi V, Longoni P, Marzona I, Milani V, Silletta MG, Tognoni G, Marchioli R. n-3 fatty acids in patients with multiple cardiovascular risk factors. N Engl J Med. 2013;368(19):1800–8.CrossRef
14.
Zurück zum Zitat ASCEND Study Collaborative Group, Bowman L, Mafham M, Wallendszus K, Stevens W, Buck G, Barton J, Murphy K, Aung T, Haynes R, Cox J, Murawska A, Young A, Lay M, Chen F, Sammons E, Waters E, Adler A, Bodansky J, Farmer A, McPherson R, Neil A, Simpson D, Peto R, Baigent C, Collins R, Parish S, Armitage J. Effects of n-3 fatty acid supplements in diabetes mellitus. N Engl J Med. 2018;379(16):1540–50.CrossRef ASCEND Study Collaborative Group, Bowman L, Mafham M, Wallendszus K, Stevens W, Buck G, Barton J, Murphy K, Aung T, Haynes R, Cox J, Murawska A, Young A, Lay M, Chen F, Sammons E, Waters E, Adler A, Bodansky J, Farmer A, McPherson R, Neil A, Simpson D, Peto R, Baigent C, Collins R, Parish S, Armitage J. Effects of n-3 fatty acid supplements in diabetes mellitus. N Engl J Med. 2018;379(16):1540–50.CrossRef
15.
Zurück zum Zitat Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, Deane KH, AlAbdulghafoor FK, Summerbell CD, Worthington HV, Song F, Hooper L. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018;7:CD003177.PubMed Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, Deane KH, AlAbdulghafoor FK, Summerbell CD, Worthington HV, Song F, Hooper L. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018;7:CD003177.PubMed
17.
Zurück zum Zitat Hamley S. The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials. Nutr J. 2017;16(1):30.CrossRefPubMedPubMedCentral Hamley S. The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials. Nutr J. 2017;16(1):30.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Mente A, O’Donnell M, Rangarajan S, Dagenais G, Lear S, McQueen M, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465–75.CrossRefPubMed Mente A, O’Donnell M, Rangarajan S, Dagenais G, Lear S, McQueen M, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465–75.CrossRefPubMed
20.
Zurück zum Zitat Baudry J, Assmann KE, Touvier M, Allès B, Seconda L, Latino-Martel P, Ezzedine K, Galan P, Hercberg S, Lairon D, Kesse-Guyot E. Association of frequency of organic food consumption with cancer risk: findings from the NutriNet-Santé Prospective Cohort Study. JAMA Intern Med. 2018;178(12):1597–606.CrossRefPubMedPubMedCentral Baudry J, Assmann KE, Touvier M, Allès B, Seconda L, Latino-Martel P, Ezzedine K, Galan P, Hercberg S, Lairon D, Kesse-Guyot E. Association of frequency of organic food consumption with cancer risk: findings from the NutriNet-Santé Prospective Cohort Study. JAMA Intern Med. 2018;178(12):1597–606.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A, Ben-Yacov O, Lador D, Avnit-Sagi T, Lotan-Pompan M, et al. Personalized nutrition by prediction of glycemic responses. Cell. 2015;163:1079–94.CrossRefPubMed Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A, Ben-Yacov O, Lador D, Avnit-Sagi T, Lotan-Pompan M, et al. Personalized nutrition by prediction of glycemic responses. Cell. 2015;163:1079–94.CrossRefPubMed
22.
Zurück zum Zitat Appel LJ, Van Horn L. Did the PREDIMED trial test a Mediterranean diet? N Engl J Med. 2013;368(14):1353–4.CrossRefPubMed Appel LJ, Van Horn L. Did the PREDIMED trial test a Mediterranean diet? N Engl J Med. 2013;368(14):1353–4.CrossRefPubMed
24.
Zurück zum Zitat D’Alessandro A, De Pergola G. The Mediterranean Diet: its definition and evaluation of a priori dietary indexes in primary cardiovascular prevention. Int J Food Sci Nutr. 2018;69(6):647–59.CrossRefPubMed D’Alessandro A, De Pergola G. The Mediterranean Diet: its definition and evaluation of a priori dietary indexes in primary cardiovascular prevention. Int J Food Sci Nutr. 2018;69(6):647–59.CrossRefPubMed
26.
Zurück zum Zitat Li Y, Pan A, Wang DD, Liu X, Dhana K, Franco OH, Kaptoge S, Di Angelantonio E, Stampfer M, Willett WC, Hu FB. Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018;138(4):345–55.CrossRefPubMedPubMedCentral Li Y, Pan A, Wang DD, Liu X, Dhana K, Franco OH, Kaptoge S, Di Angelantonio E, Stampfer M, Willett WC, Hu FB. Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018;138(4):345–55.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Springmann M, Mason-D’Croz D, Robinson S, Wiebe K, Godfray HCJ, Rayner M, et al. Health-motivated taxes on red and processed meat: a modelling study on optimal tax levels and associated health impacts. PLoS ONE. 2008;13(11):e0204139.CrossRef Springmann M, Mason-D’Croz D, Robinson S, Wiebe K, Godfray HCJ, Rayner M, et al. Health-motivated taxes on red and processed meat: a modelling study on optimal tax levels and associated health impacts. PLoS ONE. 2008;13(11):e0204139.CrossRef
28.
Zurück zum Zitat Schwingshackl L, Schwedhelm C, Hoffmann G, Lampousi AM, Knüppel S, Iqbal K, et al. Food groups and risk of all-cause mortality: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr. 2017;105(6):1462–73.PubMed Schwingshackl L, Schwedhelm C, Hoffmann G, Lampousi AM, Knüppel S, Iqbal K, et al. Food groups and risk of all-cause mortality: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr. 2017;105(6):1462–73.PubMed
29.
Zurück zum Zitat Zhao LG, Zhang QL, Zheng JL, Li HL, Zhang W, Tang WG, et al. Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies. Sci Rep. 2016;6:26983.CrossRefPubMedPubMedCentral Zhao LG, Zhang QL, Zheng JL, Li HL, Zhang W, Tang WG, et al. Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies. Sci Rep. 2016;6:26983.CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024.CrossRefPubMedPubMedCentral Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024.CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Schoenfeld JD, Ioannidis JP. Is everything we eat associated with cancer? A systematic cookbook review. Am J Clin Nutr. 2013;97(1):127–34.CrossRefPubMed Schoenfeld JD, Ioannidis JP. Is everything we eat associated with cancer? A systematic cookbook review. Am J Clin Nutr. 2013;97(1):127–34.CrossRefPubMed
32.
Zurück zum Zitat Archer E, Hand GA, Blair SN. Validity of US nutritional surveillance: National Health and Nutrition Examination Survey caloric energy intake data, 1971–2010. PLoS ONE. 2013;8(10):e76632.CrossRefPubMedPubMedCentral Archer E, Hand GA, Blair SN. Validity of US nutritional surveillance: National Health and Nutrition Examination Survey caloric energy intake data, 1971–2010. PLoS ONE. 2013;8(10):e76632.CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Bellach B, Kohlmeier L. Energy adjustment does not control for differential recall bias in nutritional epidemiology. J Clin Epidemiol. 1998;51(5):393–8.CrossRefPubMed Bellach B, Kohlmeier L. Energy adjustment does not control for differential recall bias in nutritional epidemiology. J Clin Epidemiol. 1998;51(5):393–8.CrossRefPubMed
34.
Zurück zum Zitat Bernstein DM, Loftus EF. The consequences of false memories for food preferences and choices. Perspect Psychol Sci. 2009;4(2):135–9.CrossRefPubMed Bernstein DM, Loftus EF. The consequences of false memories for food preferences and choices. Perspect Psychol Sci. 2009;4(2):135–9.CrossRefPubMed
35.
Zurück zum Zitat Straube B. An overview of the neuro-cognitive processes involved in the encoding, consolidation, and retrieval of true and false memories. Behav Brain Funct. 2012;8(1):35.CrossRefPubMedPubMedCentral Straube B. An overview of the neuro-cognitive processes involved in the encoding, consolidation, and retrieval of true and false memories. Behav Brain Funct. 2012;8(1):35.CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Stang PE, Ryan PB, Overhage JM, Schuemie MJ, Hartzema AG, Welebob E. Variation in choice of study design: findings from the epidemiology design decision inventory and evaluation (EDDIE) survey. Drug Saf. 2013;36(S1):15–25.CrossRef Stang PE, Ryan PB, Overhage JM, Schuemie MJ, Hartzema AG, Welebob E. Variation in choice of study design: findings from the epidemiology design decision inventory and evaluation (EDDIE) survey. Drug Saf. 2013;36(S1):15–25.CrossRef
39.
Zurück zum Zitat Silberzahn R, Uhlmann EL, Martin DP, Anselmi P, Aust F, Awtrey E, et al. Many analysts, one data set: making transparent how variations in analytic choices affect results. Adv Methods Pract Psychol Sci. 2018;1(3):337–56.CrossRef Silberzahn R, Uhlmann EL, Martin DP, Anselmi P, Aust F, Awtrey E, et al. Many analysts, one data set: making transparent how variations in analytic choices affect results. Adv Methods Pract Psychol Sci. 2018;1(3):337–56.CrossRef
40.
Zurück zum Zitat Serghiou S, Patel CJ, Tan YY, Koay P, Ioannidis JP. Field-wide meta-analyses of observational associations can map selective availability of risk factors and the impact of model specifications. J Clin Epidemiol. 2016;71:58–67.CrossRefPubMed Serghiou S, Patel CJ, Tan YY, Koay P, Ioannidis JP. Field-wide meta-analyses of observational associations can map selective availability of risk factors and the impact of model specifications. J Clin Epidemiol. 2016;71:58–67.CrossRefPubMed
41.
Zurück zum Zitat Patel CJ, Burford B, Ioannidis JP. Assessment of vibration of effects due to model specification can demonstrate the instability of observational associations. J Clin Epidemiol. 2015;68(9):1046–58.CrossRefPubMedPubMedCentral Patel CJ, Burford B, Ioannidis JP. Assessment of vibration of effects due to model specification can demonstrate the instability of observational associations. J Clin Epidemiol. 2015;68(9):1046–58.CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328(20):1450–6.CrossRefPubMed Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328(20):1450–6.CrossRefPubMed
43.
Zurück zum Zitat Bjelakovic G, Nikolova D, Gluud C. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS ONE. 2013;8(9):e74558.CrossRefPubMedPubMedCentral Bjelakovic G, Nikolova D, Gluud C. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS ONE. 2013;8(9):e74558.CrossRefPubMedPubMedCentral
44.
Zurück zum Zitat Ioannidis JP, Adami H-O. Nested randomized trials in large cohorts and biobanks: studying the health effects of lifestyle factors. Epidemiology. 2008;19(1):75–82.CrossRefPubMed Ioannidis JP, Adami H-O. Nested randomized trials in large cohorts and biobanks: studying the health effects of lifestyle factors. Epidemiology. 2008;19(1):75–82.CrossRefPubMed
45.
47.
Zurück zum Zitat Patel CJ, Ioannidis JP. Placing epidemiological results in the context of multiplicity and typical correlations of exposures. J Epidemiol Community Health. 2014;68(11):1096–100.CrossRefPubMed Patel CJ, Ioannidis JP. Placing epidemiological results in the context of multiplicity and typical correlations of exposures. J Epidemiol Community Health. 2014;68(11):1096–100.CrossRefPubMed
48.
Zurück zum Zitat Patel CJ, Cullen MR, Ioannidis JP, Butte AJ. Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol. 2012;41(3):828–43.CrossRefPubMedPubMedCentral Patel CJ, Cullen MR, Ioannidis JP, Butte AJ. Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol. 2012;41(3):828–43.CrossRefPubMedPubMedCentral
49.
51.
Zurück zum Zitat Ioannidis JPA, Loy EY, Poulton R, et al. Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification. Sci Transl Med. 2009;1(7):7ps8.CrossRefPubMed Ioannidis JPA, Loy EY, Poulton R, et al. Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification. Sci Transl Med. 2009;1(7):7ps8.CrossRefPubMed
52.
Zurück zum Zitat Ioannidis JPA, Klavans R, Boyack KW. Thousands of scientists publish a paper every five days. Nature. 2018;561(7722):167–9.CrossRefPubMed Ioannidis JPA, Klavans R, Boyack KW. Thousands of scientists publish a paper every five days. Nature. 2018;561(7722):167–9.CrossRefPubMed
Metadaten
Titel
Unreformed nutritional epidemiology: a lamp post in the dark forest
verfasst von
John P. A. Ioannidis
Publikationsdatum
12.02.2019
Verlag
Springer Netherlands
Erschienen in
European Journal of Epidemiology / Ausgabe 4/2019
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-019-00487-5

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