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Journal of Assisted Reproduction and Genetics

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01.07.2011 | Gonadal Physiology and Disease

The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study

verfasst von: Sedigheh Ghandi, Abbas Aflatoonian, Nasim Tabibnejad, Mohammad Hossein Sojoodi Moghaddam

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2011

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Abstract

Purpose

Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome.

Methods

A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects’ ovulatory status was assessed after 3 months.

Results

There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH.

Conclusions

Both metformin and orlistat showed a similar effect on weight loss and ovulation rates.

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Titel: The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study
verfasst von: Sedigheh Ghandi
Abbas Aflatoonian
Nasim Tabibnejad
Mohammad Hossein Sojoodi Moghaddam
Publikationsdatum: 01.07.2011
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 7/2011
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9564-2

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The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study

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Purpose

Methods

Results

Conclusions

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