nach oben

Erschienen in:

01.03.2007

Serological and Clinical Comparison of Children and Adults with Anti-Endomysial Antibodies

verfasst von: Branka Bonaci-Nikolic, Sladjana Andrejevic, Nedeljko Radlovic, Ivana Davidovic, Ljiljana Sofronic, Milan Spuran, Marjan Micev, Milos M. Nikolic

Erschienen in: Journal of Clinical Immunology | Ausgabe 2/2007

Einloggen, um Zugang zu erhalten

Abstract

We compared serological and clinical presentation of 38 adults (5 males, 33 females) and 37 children (15 boys, 22 girls) with anti-endomysial antibodies (AEA).

AEA, antinuclear (ANA), anti-parietal (APA), anti-thyroid microsomal (ATMA), anti-thyreoglobulin (ATGA), anti-smooth muscle (SMA) and anti-mitochondrial (AMA) antibodies were detected by IIF. Anti-tissue transglutaminase (tTG), anti-extractable nuclear antigens (ENA) and anti-actin (AAA) antibodies were studied by ELISA.

There were no differences in frequency of ANA, APA, ATGA, SMA, AMA and AAA in children and adults. ATMA (p < 0.001) and anti-ENA (p < 0.05) positivity were more frequently found in adults. Anti-Ro/SSA had 7/38 adults and 1/37 children (p < 0.05). Adults had more frequently silent form of celiac disease associated with autoimmune diseases (p < 0.001).

We are the first to demonstrate that in spite of no difference in ANA positivity in adults and children, ANA in adults more frequently target ENA, especially Ro/SSA antigen. The reason for this ANA specificity could be the longer gluten exposure in adults.

Stepniak D, Koning F: Celiac disease-sandwiched between innate and adaptive immunity. Hum Immunol 67:460–468, 2006PubMedCrossRef

Working Group of European Society of Pediatric Gastroenterology and Nutrition. Revised criteria for diagnosis of coeliac disease. Arch Dis Child 65:909–911, 1990

Remes-Troche JM, Ramirez-Iglesias MT, Rubio-Tapia A, Alonso-Ramos A, Velazquez A, Uscanga LF: Celiac disease could be a frequent disease in Mexico: Prevalence of tissue transglutaminase antibody in healthy blood donors. J Clin Gastroenterol 40:697–700, 2006PubMedCrossRef

West J, Logan RF, Hill PG, Lloyd A, Lewis S, Hubbard R, Reader R, Holmes GK, Khaw KT: Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 52:960–965, 2003PubMedCrossRef

Ravikumara M, Tuthill DP, Jenkins HR: The changing clinical presentation of coeliac disease. Arch Dis Child 91:969–971, 2006PubMedCrossRef

Green PHR, Jabri B: Coeliac disease. The Lancet 362:383–391, 2003CrossRef

Murray JA, Herlein J, Mitros F, Goeken JA: Serologic testing for celiac disease in the United States: Results of a multilaboratory comparison study. Clin Diagn Lab Immunol 7:584–587, 2000PubMedCrossRef

Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D: Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:797–801, 1997PubMedCrossRef

Ventura A, Neri E, Ughi C, Leopaldi A, Citta A, Not T: Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease. J Pediatr 137:263–265, 2000PubMedCrossRef

10.

Sanchez D, Tuckova L, Sebo P, Michalak M, Whelan A, Sterzl I, Jelinkova L, Havrdova E, Imramovska M, Benes Z, Krupickova S, Tlaskalova-Hogenova H: Occurrence of IgA and IgG autoantibodies to calreticulin in coeliac disease and various autoimmune diseases. J Autoimmun 15:441–449, 2000PubMedCrossRef

11.

Smedby KE, Akerman M, Hildebrand H, Glimelius B, Ekbom A, Askling J: Malignant lymphomas in coeliac disease: Evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma. Gut 54:54–59, 2005PubMedCrossRef

12.

Sategna Guidetti C, Solerio E, Scaglione N, Aimo G, Mengozzi G: Duration of gluten exposure in adult coeliac disease does not corelate with the risk for autoimmune disorders. Gut 49:502–505, 2001PubMedCrossRef

13.

Ventura A, Magazzu G, Greco L: Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology 117:297–303, 1999PubMedCrossRef

14.

Fenoglio-Preiser CM: The non-neoplastic small intestine. In Gastrointestinal Pathology, An Atlas and Text, CM Fenoglio-Preiser (ed). New York, Raven Press, 1989, pp 245–357

15.

Freeman HJ: Adult coeliac disease and severe flat small bowel biopsy lesion. Dig Dis Sci 49:535–545, 2004PubMedCrossRef

16.

Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH: European Study Group on Classification Criteria for Sjogren’s Syndrome. Classification criteria for Sjogren’s syndrome: A revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554–558, 2002PubMedCrossRef

17.

Hochberg MC: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725, 1997

18.

Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, Brey R, Derksen R, Harris EN, Hughes GR, Triplett DA, Khamashta MA: International consensus statement on preliminary classification for definite antiphospholipid syndrome. Arthritis Rheum 42:1309–1311, 1999PubMedCrossRef

19.

Sharp GC: Diagnostic criteria for classification of MCTD. In Mixed Connective Tissue Diseases and Antinuclear Antibodies, R Kasukawa, GC Sharp (eds). Amsterdam, Elsevier; 1987, pp 23–32.

20.

Jameson JL, Weetman AP: Diseases of the thyroid gland. In Harrison’s Principles of Internal Medicine, 16th edn, DL Kasper, E Braunwald, AS Fauci et al. (eds), New York, McGraw-Hill, 2005, pp 2104–2127

21.

Katz SI: Dermatitis herpetiformis. In Fitzpatrick’s Dermatology in General Medicine, 5th edn, IM Freedberg, AZ Eisen, K Wolff et al. (eds), New York, McGraw-Hill, 1999, pp 709–715

22.

Sherman SI, Gagel RF: Disorders affecting multiple endocrine systems. In Harrison’s Principles of Internal Medicine. 16th edn, Kasper DL, Braunwald E, Fauci AS et al. (eds), New York, McGraw-Hill, 2005, pp 2231–2238

23.

Williams GH, Dluhy RG: Disoreders of the adrenal cortex. In Harrison’s Principles of Internal Medicine, 16th edn, Kasper DL, Braunwald E, Fauci AS et al. (eds), New York, McGraw-Hill, 2005, pp 2127–2148

24.

Valle JD: Peptic ulcer disease and related disorders. In Harrison’s Principles of Internal Medicine. 16th edn, Kasper DL, Braunwald E, Fauci AS et al. (eds), New York, McGraw-Hill, 2005, pp 1746–1763

25.

Chung RT, Podolsky: Cirrhosis and its complications. In Harrison’s Principles of Internal Medicine. 16th edn, Kasper DL, Braunwald E, Fauci AS et al. (eds), New York, McGraw-Hill, 2005, pp 1858–1869

26.

Fasano A: Clinical presentation of celiac disease in the pediatric population. In NIH consensus development conference on celiac disease. H William (ed). Natcher Conference Center National Institutes of Health Bethesda, Maryland, June 28–30, 2004

27.

Sollid LM, Jabri B: Is celiac disease an autoimmune disorder? Curr Opin Immunol 17:595–600, 2005PubMedCrossRef

28.

Rioux JD, Abbas AK: Paths to understanding the genetic basis of autoimmune disease. Nature 435:584–589, 2005PubMedCrossRef

29.

Lenhardt A, Plebani A, Marchetti F, Gerarduzzi T, Not T, Meini A, Villanacci V, Martelossi S, Ventura A: Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. Dig Liver Dis 36:730–734, 2004PubMedCrossRef

30.

Picarelli A, Sabbatella L, Di Tola M, Vetrano S, Casale C, Anania MC, Porowska B, Vergari M, Schiaffini R, Gargiulo P: Anti-endomysial antibody of IgG1 isotype detection strongly increases the prevalence of coeliac disease in patients affected by type I diabetes mellitus. Clin Exp Immunol 142:111–115, 2005PubMedCrossRef

31.

Carroccio A, Iannitto E, Di Prima L, Cirrincione S, Troncone R, Paparo F, Trapani LG, Gucciardi A, Averna MR, Montalto G, Notarbartolo A: Screening for celiac disease in non-Hodgkin’s lymphoma patients: a serum anti-transglutaminase-based approach. Dig Dis Sci 48:1530–1536, 2003PubMedCrossRef

32.

Brusco G, Muzi P, Ciccocioppo R, Biagi F, Cifone MG, Corazza GR: Transglutaminase and coeliac disease: endomysial reactivity and small bowel expression. Clin Exp Immunol 118:371–375, 1999PubMedCrossRef

33.

Babron MC, Nilsson S, Adamovic S, Naluai AT, Wahlstrom J, Ascher H, Ciclitira PJ, Sollid LM, Partanen J, Greco L, Clerget-Darpoux F: European genetics cluster on coeliac disease. Meta and pooled analysis of European coeliac disease data. Eur J Hum Genet 11:828–834, 2003PubMedCrossRef

34.

Farrell RJ, Kelly CP: Celiac sprue. N Engl J Med 346:180–188, 2002PubMedCrossRef

35.

Berti I, Trevisiol C, Tommasini A, Citta A, Neri E, Geatti O, Giammarini A, Ventura A, Not T: Usefulness of screening program for celiac disease in autoimmune thyroiditis. Dig Dis Sci 45:403–406, 2000PubMedCrossRef

36.

Hummel M, Bonifacio E, Stern M, Dittler J, Schimmel A, Ziegler AG: Development of celiac disease-associated antibodies in offspring of parents with type I diabetes. Diabetologia 43:1005–1011, 2000PubMedCrossRef

37.

Mavroudi A, Karatza E, Papastavrou T, Panteliadis C, Spiroglou K: Successful treatment of epilepsy and celiac disease with a gluten-free diet. Pediatr Neurol 33:292–295, 2005PubMedCrossRef

38.

da Rosa Utiyama SR, da Silva Kotze LM, Nisihara RM, Carvalho RF, de Carvalho EG, de Sena MG, de Messias Reason IJ: Spectrum of autoantibodies in celiac patients and relatives. Dig Dis Sci 46:2624–2630, 2001PubMedCrossRef

39.

Alarcon-Segovia D, Ruiz-Arguelles A, Llorente L: Broken dogma: penetration of autoantibodies into living cells. Immunol Today 17:163–164, 1996PubMedCrossRef

40.

Bukilica MN, Andrejevic SB, Bonaci-Nikolic BM, Nikolic MM: Speckled antinuclear antibodies in keratinocytes—what does it mean? Clin Exp Rheumatol 20:499–504, 2002PubMed

41.

Esposito C, Paparo F, Caputo I, Rossi M, Maglio M, Sblattero D, Not T, Porta R, Auricchio S, Marzari R, Troncone R: Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut 51:177–181, 2002PubMedCrossRef

42.

Byrne G, Ryan F, Jackson J, Feighery C, Kelly J: Mutagenesis of the catalytic triad of tissue transglutaminase abrogates coeliac disease serum IgA autoantibody binding. Gut 2006 Aug 25; [Epub ahead of print]

43.

Skovbjerg H, Hansen GH, Niels-Christiansen LL, Anthonsen D, Ascher H, Midhagen G, Hallert C, Noren O, Sjostrom H: Intestinal tissue transglutaminase in coeliac disease of children and adults: ultrastructural localization and variation in expression. Scand J Gastroenterol 39:1219–1227, 2004PubMedCrossRef

44.

Sassenou I, Rabhi M, Berady S, Hachim M, Toloune F: Coeliac disease and autoimmunity: about an association with autoimmune hemolytic anemia. Rev Med Interne 27:75–76, 2006PubMedCrossRef

45.

Varkel Y, Braester A, Suprun H, Nusem D, Horn Y: Simultaneous occurrence of systemic lupus erythematosus and coeliac disease-like features. Postgrad Med J 65:600–602,1989PubMedCrossRef

46.

Luft LM, Barr SG, Martin LO, Chan EK, Fritzler MJ: Autoantibodies to tissue transglutaminase in Sjogren’s syndrome and related rheumatic diseases. J Rheumatol 30:2613–2619, 2003PubMed

47.

Iltanen S, Collin P, Korpela M, Holm K, Partanen J, Polvi A, Maki M: Celiac disease and markers of celiac disease latency in patients with primary Sjogren’s syndrome. Am J Gastroenterol 94:1042–1046, 1999PubMed

48.

Tzioufas AG, Wassmuth R, Dafni UG, Guialis A, Haga HJ, Isenberg DA, Jonsson R, Kalden JR, Kiener H, Sakarellos C, Smolen JS, Sutcliffe N, Vitali C, Yiannaki E, Moutsopoulos HM: Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjogren’s syndrome (pSS): a European multicentre study. Ann Rheum Dis 61:398–404, 2002PubMedCrossRef

49.

Eggleton P, Llewellyn DH: Pathophysiological roles of calreticulin in autoimmune disease. Scand J Immunol 49:466–473, 1999PubMedCrossRef

50.

Clemente MG, Musu MP, Frau F, Brusco G, Sole G, Corazza GR, De Virgiliis S: Immune reaction against the cytoskeleton in coeliac disease. Gut 47:520–526, 2000PubMedCrossRef

51.

Bakrac M, Bonaci B, Krstic M, Simic S, Colovic M: A rare case of enteropathy-associated T-cell lymphoma presenting as acute renal failure. World J Gastroenterol 12:2301–2304, 2006PubMed

52.

Maiuri L, Ciacci C, Raia V, Vacca L, Ricciardelli I, Raimondi F, Auricchio S, Quaratino S, Londei M: FAS engagement drives apoptosis of enterocytes of coeliac patients. Gut 48:418–424, 2001PubMedCrossRef

Titel: Serological and Clinical Comparison of Children and Adults with Anti-Endomysial Antibodies
verfasst von: Branka Bonaci-Nikolic
Sladjana Andrejevic
Nedeljko Radlovic
Ivana Davidovic
Ljiljana Sofronic
Milan Spuran
Marjan Micev
Milos M. Nikolic
Publikationsdatum: 01.03.2007
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Journal of Clinical Immunology / Ausgabe 2/2007
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-006-9062-y

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

CAR-M-Zellen: Warten auf das große Fressen

22.05.2024 Onkologische Immuntherapie Nachrichten

Auch myeloide Immunzellen lassen sich mit chimären Antigenrezeptoren gegen Tumoren ausstatten. Solche CAR-Fresszell-Therapien werden jetzt für solide Tumoren entwickelt. Künftig soll dieser Prozess nicht mehr ex vivo, sondern per mRNA im Körper der Betroffenen erfolgen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Serological and Clinical Comparison of Children and Adults with Anti-Endomysial Antibodies

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

CAR-M-Zellen: Warten auf das große Fressen

Chronische Verstopfung: „Versuchen Sie es mit grünen Kiwis!“

So häufig greift rheumatoide Arthritis auf Organe über

Blutdrucksenkung könnte Uterusmyome verhindern

Update Innere Medizin

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2007

High Incidence of Morphological Myelodysplasia and Apoptotic Bone Marrow Cells in Behçet’s Disease

γδ T Lymphocytes—Selectable Cells Within the Innate System?

Efficacy and Tolerability of an Argentine Intravenous Immunoglobulin in Pediatric Patients with Primary Immunodeficiency Diseases

Gliadin Peptides Activate Blood Monocytes from Patients with Celiac Disease

Effects of Tumour Necrosis Factor-α on Human Sperm Motility and Apoptosis

The Role of Anti-α-Enolase Autoantibodies in Pathogenicity of Autoimmune-Mediated Retinopathy

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

CAR-M-Zellen: Warten auf das große Fressen

Chronische Verstopfung: „Versuchen Sie es mit grünen Kiwis!“

So häufig greift rheumatoide Arthritis auf Organe über

Blutdrucksenkung könnte Uterusmyome verhindern

Update Innere Medizin