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Journal of Clinical Immunology

Erschienen in:

01.01.2009

Immune Semaphorins: Novel Features of Neural Guidance Molecules

verfasst von: Masayuki Mizui, Atsushi Kumanogoh, Hitoshi Kikutani

Erschienen in: Journal of Clinical Immunology | Ausgabe 1/2009

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Abstract

Introduction

The immune and nervous system have various common features in the functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enables intercellular signal transduction. They also share a number of messenger molecules such as cytokines and chemical mediators.

Discussion

Semaphorins, well-defined axonal guidance molecules in the nervous system, also play critical roles in immune regulation. Various types of semaphorins, including secreted, transmembrane, truncated, and glycosylphosphatidylinositol-anchored forms, function during immune responses. However, some semaphorins utilize receptors in the immune system that are distinct from receptors in the nervous system.

Conclusion

This review presents a current overview of ‘immune semaphorins’ and their receptors, providing insight into the pleiotropic activity of this protein family.

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Titel: Immune Semaphorins: Novel Features of Neural Guidance Molecules
verfasst von: Masayuki Mizui
Atsushi Kumanogoh
Hitoshi Kikutani
Publikationsdatum: 01.01.2009
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 1/2009
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9263-7

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