nach oben

Journal of Genetic Counseling

Erschienen in:

01.08.2008 | Original Research

The Relationship Between Psychological Distress and Personality in Women from Families with Familial Breast/Ovarian or Hereditary Non-polyposis Colorectal Cancer in the Absence of Demonstrated Mutations

verfasst von: Amy Østertun Geirdal, Alv A. Dahl

Erschienen in: Journal of Genetic Counseling | Ausgabe 4/2008

Einloggen, um Zugang zu erhalten

Abstract

The aim of this study was to explore associations between mental and cancer-specific distress (psychological distress) and personality traits in healthy women belonging to families with familial cancer and absence of demonstrated mutations. We included 238 healthy women from families with familial breast-ovarian cancer (FBOC) or hereditary non-polyposis colorectal cancer (HNPCC). They responded to a questionnaire including validated instruments for psychological distress and personality traits. Information on demography and cancer-related issues were also collected. Significant associations between psychological distress and personality traits were found in these women. The traits of Optimism and Harm avoidance showed the strongest association with both types of distress. Associations between psychological distress and personality traits were observed in women from families with FBOC or HNPCC that fulfilled clinical criteria for familial breast/ovarian cancer in the absence of demonstrated mutations. Screening for such traits could be helpful in genetic counseling.

Audrain, J., Schwartz, M. D., Lerman, C., Hughes, C., & Peshkin, B. N. (1997). Psychological distress in women seeking genetic counseling for breast-ovarian cancer risk: the contributions of personality and appraisal. Annals of Behavioral Medicine, 19, 370–377.PubMedCrossRef

Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1974). The measurement of pessimism. The hopelessness scale. Journal of Consulting and Clinical Psychology, 42, 861–865.PubMedCrossRef

Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002). The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Journal of Psychosomatic Research, 52, 69–77.PubMedCrossRef

Bodd, T. L., Reichelt, J. G., Heimdal, K., & Moller, P. (2003). Uptake of BRCA1 genetic testing in adult sisters and daughters of known mutation carriers in Norway. Journal of Genetic Counseling, 12, 405–417.PubMedCrossRef

Brandstrom, S., Schlette, P., Przybeck, T. R., Lundberg, M., Forsgren, T., Sigvardsson, S., et al. (1998). Swedish normative data on personality using the Temperament and Character Inventory. The Comprehensive Psychiatry, 39, 122–128.PubMedCrossRef

Broadstock, M., Michie, S., & Marteau, T. (2000). Psychological consequences of predictive genetic testing: a systematic review. European Journal of Human Genenetics, 8, 731–738.CrossRef

Carver, C. S., Pozo-Kaderman, C., Harris, S. D., Noriega, V., Scheier, M. F., Robinson, D. S., et al. (1994). Optimism versus pessimism predicts the quality of women’s adjustment to early stage breast cancer. Cancer, 73, 1213–1220.PubMedCrossRef

Claes, E., Evers-Kiebooms, G., Denayer, L., Decruyenaere, M., Boogaerts, A., Philippe, K., et al. (2005). Predictive genetic testing for hereditary breast and ovarian cancer: Psychological distress and illness representations 1 year following disclosure. Journal of Genetic Counseling, 14, 349–363.PubMedCrossRef

Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50, 975–990.PubMed

Cloninger, C. R., Przybeck, T. R., Svrakic, D. M., & Wetzel, R. D. (1994). The temperament and character inventory (TCI): A guide to its development and use. St. Louis, MO: Center for Psychobiology of personality, Washington University.

Cohen, J. (1988). Statistical power analysis for the behavioural sciences (2nd ed.). Hillsdale NJ: Earlbaum.

Farmer, A., Mahmood, A., Redman, K., Harris, T., Sadler, S., & McGuffin, P. (2003). A sib-pair study of the Temperament and Character Inventory Scales in major depression. Archives of General Psychiatry, 60, 490–496.PubMedCrossRef

Geirdal, A. Ø., Reichelt, J. G., Dahl, A. A., Heimdal, K., Mæhle, L., Stormorken, A., et al. (2005). Psychological distress in women at risk for hereditary breast/ovarian or HNPCC cancers in the absence of demonstrated mutations. Familial Cancer, 4, 121–126.PubMedCrossRef

Geirdal, A. Ø., Maehle, L., Heimdal, K., Stormorken, A., Moller, P., & Dahl, A. A. (2006). Quality of life and its relation to cancer-related stress in women of families with hereditary cancer without demonstrated mutation. Quality of Life Research, 15, 461–470.PubMedCrossRef

Grann, V. R., & Jacobson, J. S. (2002). Population screening for cancer-specific germline gene mutations. Lancet Oncology, 3, 341–348.PubMedCrossRef

Halvorsen, I., & Heyerdahl, S. (2006). Girls with anorexia nervosa as young adults: personality self-esteem, and life satisfaction. International Journal of Eating Disorder, 39, 285–293.CrossRef

Hansenne, M., Reggers, J., Pinto, E., Kjiri, K., Ajamier, A., & Ansseau, M. (1999). Temperament and Character inventory (TCI) and depression. Journal of Psychiatric Resarch, 33, 31–36.CrossRef

Hansenne, M., Deljez, M., & Cloninger, C. R. (2005). Psychometric properties of the temperament and character inventory-revised (TCI-R) in a Belgian sample. Journal of Personality Assessment, 85, 40–49.PubMedCrossRef

Holi, M., Sammallathi, P. R., & Aalberg, V. A. (1999). Defense styles explain psychiatric symptoms: an empirical study. The Journal of Nervous and Mental Disease, 187, 654–660.PubMedCrossRef

Joffe, R. T., Bagby, R. M., Levitt, A. J., Regan, J. J., & Parker, J. D. (1993). The Tridimensional Personality Questionnaire in major depression. The American Journal of Psychiatry, 150, 959–960.PubMed

Jorm, A. F., Christensen, H., Henderson, A. S., Jacomb, P. A., Korten, A. E., & Rodgers, B. (2000). Predicting anxiety and depression from personality: is there a synergistic effect of neuroticism and extraversion? Journal of Abnormal Psychology, 109, 145–149.PubMedCrossRef

Jÿlhä, P., & Isometsä, E. (2006). Temperament, character of anxiety and depression in the general population. European Psychiatry, 21, 389–395.PubMedCrossRef

Lim, J., Macluran, M., Price, M., Bennett, B., Butow, P., & the kConfab Psychological Group (2004). Short- and long-term impact of receiving genetic mutation results in women at increased risk for hereditary breast cancer. Journal of Genetic Counseling, 13, 115–133.PubMedCrossRef

Lipsey, M. W., & Wilson, D. B. (2001). Practical meta-analysis. Thousand Oaks, CA: Sage.

Meiser, B. (2005). Psychological impact of genetic testing for cancer susceptibility: an update of the literature. Psychooncologyogy, 14, 1060–1074.CrossRef

Meiser, B., & Halliday, J. L. (2002). What is the impact of genetic counseling in women at increased risk of developing hereditary breast cancer? A meta-analytic review. Social Science and Medicine, 54, 463–470.

Miettunen, J., Kantojarvi, L., Ekelund, J., Veijola, J., Karvonen, J. T., Peltonen, L., et al. (2004). A large population cohort provides normative data for investigation of temperament. Acta Psychiatrica Scandinavica, 110, 150–157.PubMedCrossRef

Moller, P., Borg, A., Heimdal, K., Apold, J., Vallon-Christersson, J., Hovig, E., et al. (2001). The Norwegian Inherited Breast Cancer Group; The Norwegian Inherited Ovarian Cancer Group. The BRCA1 syndrome and other inherited breast or breast-ovarian cancers in a Norwegian prospective series. The European Journal of Cancer, 37, 1027–1032.PubMedCrossRef

Moller, P., Evans, G., Haites, N., Vasen, H., Reis, M. M., Anderson, E., et al. (1999). Guidelines for follow-up of women at high risk for inherited breast cancer: Consensus statement from the Biomed 2 Demonstration Programme on Inherited Breast Cancer. Disease Markers, 15, 207–211.PubMed

Mykletun, A., Stordal, E., & Dahl, A. A. (2001). The Hospital Anxiety and Depression Scale (HADS): factor structure, item analyses, and internal consistency in a large population. British Journal of Psychiatry, 79, 340–344.

Neeleman, J., Bijl, R., & Ormel, J. (2004). Neuroticism, a central link between somatic and psychiatric morbidity: path analysis of prospective data. Psychological Medicine, 34, 521–531.PubMedCrossRef

Neeleman, J., Sytema, S., & Wadsworth, M. (2002). Propensity to psychiatric and somatic ill-health: evidence from a birth cohort. Psychological Medicine, 32, 793–803.PubMedCrossRef

Nes, L. S., & Segerstrom, S. C. (2006). Dispositional optimism and coping: A meta-analytic review. Personality and Social Psychology Review, 10, 235–251.PubMedCrossRef

Pasacreta, J. V. (2003). Mental issues associated with genetic testing for breast and ovarian cancer risk: an integrative review. Cancer Investigation, 21, 588–623.PubMedCrossRef

Reichelt, J. G., Heimdal, K., Møller, P., & Dahl, A. A. (2004). BRCA1 testing with definite results: a prospective study of psychological distress in a large clinic-based sample. Familial Cancer, 3, 21–28.PubMedCrossRef

Scheier, M. F., & Carver, C. S. (1985). Optimism, coping, and health: assessment and implications of generalized outcome expectancies. Health Psychology, 4, 219–247.PubMedCrossRef

Schlich-Bakker, K. J., ten Kroode, H. F. J., & Ausems, M. G. E. M. (2006). A literature review of the psychological impact of genetic testing on breast cancer patients. Patient Education and Counseling, 62, 13–20.PubMedCrossRef

Schou, I., Ekeberg, Ø., Sandvik, L., & Ruland, C. M. (2005). Stability in optimism-pessimism in relation to bad news: a study of women with breast cancer. Journal of Personality Assessment, 84, 148–154.PubMedCrossRef

Smith, A. B., Wright, E. P., Rush, R., Stark, D. P., Velikova, G., & Selby, P. J. (2006). Rasch analysis of the dimensional structure of the Hospital Anxiety and Depression Scale. Psychooncology, 15, 817–827.PubMedCrossRef

Steed, L. (2001). Further validity and reliability evidence for Beck hopelessness scale scores in a nonclinical sample. Educational and Psychological Measurement, 61, 303–316.CrossRef

Sundin, E. C., & Horowitz, M. J. (2002). Impact of Event Scale: psychometric properties. The British Journal of Psychiatry, 180, 205–209.PubMedCrossRef

Thewes, B., Meiser, B., & Hickie, I. B. (2001). Psychometric properties of the Impact of Event Scale amongst women at increased risk for hereditary breast cancer. Psychooncology, 10, 459–468.PubMedCrossRef

Tjemsland, L., Soreide, J. A., & Malt, U. F. (1998). Posttraumatic distress symptoms in operable breast cancer III: status one year after surgery. Breast Cancer Research and Treatment, 47, 141–151.PubMedCrossRef

van Dijk, S., Timmermans, D. R., Meijers-Heijboer, H., Tibben, A., van Asperen, C. J., & Otten, W. (2006). Clinical characteristics affect the impact of an uninformative DNA test result: the course of worry and distress experienced by women who apply for genetic testing for breast cancer. Journal of Clinical Oncology, 24, 3672–3677.PubMedCrossRef

van Oostrom, I., Meijers-Heijboer, H., Lodder, L. N., Duivenvoorden, H. J., van Gool, A. R., Seynaeve, C., et al. (2003). Long-term psychological impact of carrying a BRCA1/2 mutation and prophylactic surgery: A 5-year follow-up study. Journal of Clinical Oncology, 21, 3867–3874.PubMedCrossRef

Vasen, H. F., Watson, P., Mecklin, J. P., & Lynch, H. T. (1999). New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology, 116, 1453–1456.PubMedCrossRef

Watson, D. C., & Sinha, B. K. (1998). Gender, age, and cultural differences in the Defense Style Questionnaire-40. Journal of Clinical Psychology, 54, 67–75.PubMedCrossRef

Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67, 361–370.PubMedCrossRef

Titel: The Relationship Between Psychological Distress and Personality in Women from Families with Familial Breast/Ovarian or Hereditary Non-polyposis Colorectal Cancer in the Absence of Demonstrated Mutations
verfasst von: Amy Østertun Geirdal
Alv A. Dahl
Publikationsdatum: 01.08.2008
Verlag: Springer US
Erschienen in: Journal of Genetic Counseling / Ausgabe 4/2008
Print ISSN: 1059-7700
Elektronische ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-008-9159-y

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

15.05.2024 Mammakarzinom Nachrichten

Frauen mit lokalem oder metastasiertem Brustkrebs, die Statine einnehmen, haben eine niedrigere krebsspezifische Mortalität als Patientinnen, die dies nicht tun, legen neue Daten aus den USA nahe.

Neue S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Gestationsdiabetes: In der zweiten Schwangerschaft folgenreicher als in der ersten

13.05.2024 Gestationsdiabetes Nachrichten

Das Risiko, nach einem Gestationsdiabetes einen Typ-2-Diabetes zu entwickeln, hängt nicht nur von der Zahl, sondern auch von der Reihenfolge der betroffenen Schwangerschaften ab.

Embryotransfer erhöht womöglich Leukämierisiko der Kinder

13.05.2024 Assistierte Reproduktion Nachrichten

Reproduktionsmedizinische Techniken haben theoretisch das Potenzial, den epigenetischen Code zu verändern und somit das Krebsrisiko der Kinder zu erhöhen. Zwischen Embryotransfer und Leukämie scheint sich ein solcher Zusammenhang bestätigt zu haben.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2008

“I Wouldn’t Classify Myself as a Patient”: The Importance of a “Well-being” Environment for Individuals Receiving Counseling about Familial Cancer Risk

Editorial

Family History of Pancreatic Cancer in a High-Risk Cancer Clinic: Implications for Risk Assessment

Lessons Learned: Risk Management Issues in Genetic Counseling