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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.12.2007

Molecular Determinants of Milk Lipid Secretion

verfasst von: James L. McManaman, Tanya D. Russell, Jerome Schaack, David J. Orlicky, Horst Robenek

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 4/2007

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Abstract

Mammary epithelial cells secrete lipids by an envelopment process that produces lipid droplets coated by membranes derived from the plasma membrane and possibly secretory vesicles. This secretion process, which resembles viral budding, is hypothesized to be mediated by specific interactions between molecules on the surface of intracellular lipids and membrane elements of the cell. Multiple lines of evidence indicate that milk lipid secretion occurs through a tripartite complex between the integral transmembrane protein, butyrophilin (BTN); the soluble metabolic enzyme, xanthine oxidoreductase (XOR); and the lipid droplet surface protein, adipophilin (ADPH). However, topological evidence from freeze-fracture replica immunolabelling (FRIL) challenge this model and suggests that milk lipid secretion is mediated by butyrophilin alone. Advances in our understanding of the molecular, structural, and functional properties of these proteins now make it possible to understand the physiological functions of each of these molecules in detail and to identify the specific molecular determinants that mediate milk lipid secretion.

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Titel: Molecular Determinants of Milk Lipid Secretion
verfasst von: James L. McManaman
Tanya D. Russell
Jerome Schaack
David J. Orlicky
Horst Robenek
Publikationsdatum: 01.12.2007
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 4/2007
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-007-9053-5

Springer Medizin

Molecular Determinants of Milk Lipid Secretion

Abstract

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