nach oben

Erschienen in:

01.08.2007 | Lab Investigation-Human/Animal tissue

The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells

verfasst von: Yi-fang Ping, Xiao-hong Yao, Jian-hong Chen, Hong Liu, Dai-lun Chen, Xiang-dong Zhou, Ji Ming Wang, Xiu-wu Bian

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2007

Einloggen, um Zugang zu erhalten

Abstract

The chemokine receptor CXCR4 plays an important role in tumor growth, angiogenesis and metastasis. Our previous studies showed that Nordy, a synthetic chiral compound of nordihydroguaiaretic acid, inhibited the growth and angiogenesis of various malignant tumors. In this study we examined the capacity of Nordy to regulate CXCR4–mediated production of angiogenic factors by human glioblastoma cells. We found that Nordy potently inhibited CXCR4 ligand SDF-1-induced production of IL-8 and vascular endothelial cell growth factor, two important angiogenic factors implicated in the progression of malignant tumors. Further study revealed that the effect of Nordy was attributable to its down-regulation of the expression of functional CXCR4 in glioblastoma cells. These results suggest that the anti-cancer activity of Nordy is due, at least in part, to its suppression of the chemokine receptor CXCR4 thus reducing the production of angiogenic factors by tumor cells.

Bian XW, Jiang XF, Chen JH, Bai JS, Dai C, Wang QL, Lu JY, Zhao W, Xin R, Liu MY, Shi JQ, Wang JM (2006) Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas. Int Immunopharmacol 6:90–99PubMedCrossRef

Bian XW, Chen JH, Jiang XF, Bai JS, Wang QL, Zhang X (2004) Angiogenesis as an immunopharmacologic target in inflammation and cancer. Int Immunopharmacol 4:1537–1547PubMedCrossRef

Rempel SA, Dudas S, Ge S, Gutierrez JA (2000) Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 6:102–111PubMed

Bertolini F, Dell’ Agnola C, Mancoso P, Rabascio C,Burlini A, Monestiroli S,Gobbi A, Pruneri G,Martinelli G (2002) CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin’s lymphoma. Cancer Res 62:3106–3112PubMed

Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E, Zlotnik A (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50–56PubMedCrossRef

Wang JM, Deng X, Gong W, Su S (1998) Chemokines and their role in tumor growth and metastasis. J Immunol Methods 220:1–17PubMedCrossRef

Yang SX, Chen JH, Jiang XF, Wang QL, Chen ZQ, Zhao W, Feng YH, Xin R, Shi JQ, Bian XW (2005) Activation of chemokine receptor CXCR4 in malignant glioma cells promotes the production of vascular endothelial growth factor. Biochem Biophys Res Commun 335:523–528PubMedCrossRef

Suratt BT, Petty JM, Young SK, Malcolm KC, Lieber JG, Nick JA, Gonzalo JA, Henson PM (2004) Worthen GS:Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood 104:565–571PubMedCrossRef

Balkwill F (2004) The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 14:171–179PubMedCrossRef

10.

Hu J, Deng X, Bian X, Li G, Tong Y, Li Y, Wang Q, Xin R, He X, Zhou G, Xie P, Li Y; Wang JM, Cao Y (2005) The expression of functional chemokine receptor CXCR4 is associated with the metastatic potential of human nasopharyngeal carcinoma. Clin Cancer Res 11:4658–4665PubMedCrossRef

11.

Chen JH, Bian XW, Yao XH, Gong W, Hu J, Chen K, Iribarren P, Zhao W, Zhou XD (2006) Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. Biochem Biophys Res Commun 342:1368–1374PubMedCrossRef

12.

Zhou Y, Bian X, Le Y, Gong W, Hu J, Zhang X, Wang L, Iribarren P, Salcedo R, Howard OM, Farrar W, Wang JM (2005) Formylpeptide receptor FPR and the rapid growth of malignant human gliomas. J Natl Cancer Inst 97:823–835PubMedCrossRef

13.

Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstadt H (2002) Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol 168:6244–6252PubMed

14.

Hjortland GO, Lillehammer T, Somme S, Wang J, Halvorsen T, Juell S, Hirschberg H, Fodstad O, Engebraaten O (2004) Plasminogen activator inhibitor-1 increases the expression of VEGF in human glioma cells. Exp Cell Res 294:130–139PubMedCrossRef

15.

Bello L,Giussani C,Carrabba G, Pluderi M, Costa F, Bikfalvi A (2004) Angiogenesis and invasion in gliomas. Cancer Treat Res 117:263–284PubMed

16.

Cheng SY, Nagane M, Huang HS, Cavenee WK (1997) Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF 165 but not VEGF 189. Proc Natl Acad Sci USA 94:12081–12087PubMedCrossRef

17.

Zagzag D (1995) Angiogenic growth factors in neural embryogenesisn and neoplasia. Am J Pathol 146:293–309PubMed

18.

Fischer I, Gagner JP, Law M, Newcomb EW, Zagzag D (2005) Angiogenesis in gliomas: biology and molecular pathophysiology. Brain Pathol 15:297–310PubMedCrossRef

19.

Gagner JP, Law M, Fischer I, Newcomb EW, Zagzag D (2005) Angiogenesis in glioma:imaging and experimental therapeutics. Brain Pathol 15:342–363PubMedCrossRef

20.

Wang DY, Anderson JC, Gladson CL (2005) The role of the extracellular matrix in angiogenesis in malignant glioma tumors. Brain Pathol 15:318–326PubMedCrossRef

21.

Cai J, Jiang WG, Ahmed A, Boulton M (2006) Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS. Microvasc Res 71:20–31PubMedCrossRef

22.

Baba Y, Kato Y, Mochimatsu I, Nagashima Y, Kurihara M, Kawano T, Taguchi T, Hata R, Tsukuda M (2004) Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells. Clin Exp Metastasis 21:419–425PubMedCrossRef

23.

Miura S, Fujino M, Matsuo Y, Tanigawa H, Saku K (2005) Nifedipine-induced vascular endothelial growth factor secretion from coronary smooth muscle cells promotes endothelial tube formation via the kinase insert domain-containing receptor/fetal liver kinase-1/NO pathway. Hypertens Res 28:147–153PubMedCrossRef

24.

Bont ES, Rosati S, Jacobs S, Kamps WA, Vellenga E (2001) Increased bone marrow vascularization in patients with acute myeloid leukaemia: a possible role for vascular endothelial growth factor. Br J Haematol 113:296–304PubMedCrossRef

25.

Acker T, Beck H, Plate KH (2001) Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization. Mech Dev 108:45–57PubMedCrossRef

26.

Koch AE, Polverini PJ,Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG, Strieter RM (1992) Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258:1798–1801PubMedCrossRef

27.

Li A, Dubey S, Varney ML, Dave BJ, Singh RK (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170:3369–3376PubMed

28.

Salcedo R, Resau JH, Halverson D, Hudson EA, Dambach M, Powell D, Wasserman K, Oppenheim JJ (2000) Differential expression and responsiveness of chemokine receptors (CXCR1–3) by human microvascular endothelial cells and umbilical vein endothelial cells. FASEB J 14:2055–2064PubMedCrossRef

29.

Smith DR, Polverini PJ, Kunkel SL, Orringer MB, Whyte RI, Burdick MD, Wilke CA, Strieter RM (1994) Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. J Exp Med 179:1409–1415PubMedCrossRef

30.

Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP, Baker CH, Gallick GE (2005) Expression and activity of Src regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Res 65:7214–7222PubMedCrossRef

31.

Desbaillets I, Diserens AC, Tribolet N, Hamou MF, VanMeir EG (1997) Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med 186:1201–1212PubMedCrossRef

32.

Brat DJ, Bellail AC, Van Meir EG (2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro-oncol 7:122–133PubMedCrossRef

33.

Wakabayashi Y, Shono T, Isono M, Hori S, Matsushima K, Ono M, Kuwano M (1995) Dual pathways of tubular morphogenesis of vascular endothelial cells by human glioma cells: vascular endothelial growth factor/basic fibroblast growth factor and interleukin-8. Jpn J Cancer Res 86:1189–1197PubMed

34.

Darash YM, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, Beider K, Avniel S, Kasem S, Galun E, Peled A (2004) Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 18:1240–1242

35.

Lin TJ, Issekutz TB, Marshall JS (2001) SDF-1 induces IL-8 production and transendothelial migration of human cord blood-derived mast cells. Int Arch Allergy Immunol 124:142–145PubMedCrossRef

36.

Wang J, Wang J, Sun Y, Song W, Nor JE, Wang CY, Russell S. Taichman RS (2005) Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. Cell Signal 17:1578–1592PubMedCrossRef

Titel: The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells
verfasst von: Yi-fang Ping
Xiao-hong Yao
Jian-hong Chen
Hong Liu
Dai-lun Chen
Xiang-dong Zhou
Ji Ming Wang
Xiu-wu Bian
Publikationsdatum: 01.08.2007
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Journal of Neuro-Oncology / Ausgabe 1/2007
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-007-9349-8

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2007

Symptomatic central canal rupture heralding the presence of an asymptomatic conus dermoid

Dexamethasone inhibits proliferation and stimulates ecto-5′-nucleotidase/CD73 activity in C6 rat glioma cell line

Long-term follow-up results of postoperative radiation therapy for Cushing’s disease

The combined effects of multiple chemotherapeutic agents for malignant glioma cells

Treatment of CNS dissemination in systemic lymphoma