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Erschienen in: Journal of Neuro-Oncology 3/2011

01.12.2011 | CLINICAL STUDY – PATIENT STUDY

IDH mutation status impact on in vivo hypoxia biomarkers expression: new insights from a clinical, nuclear imaging and immunohistochemical study in 33 glioma patients

verfasst von: Philippe Metellus, Carole Colin, David Taieb, Eric Guedj, Isabelle Nanni-Metellus, Andre Maues de Paula, Cécile Colavolpe, Stephane Fuentes, Henry Dufour, Marylin Barrie, Olivier Chinot, L’Houcine Ouafik, Dominique Figarella-Branger

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2011

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Abstract

Mutations in the gene encoding isocitrate dehydrogenase enzyme isoforms 1 (IDH1) and 2 (IDH2) have recently been identified in a large proportion of glial tumors of the CNS, but their mechanistic role in tumor development remains unclear. Here, we assessed the actual impact of IDH1 and IDH2 mutations in patients harboring WHO grade II and III gliomas. We sequenced IDH1 at codon 132 and IDH2 at codon 172 in 33 patients with WHO grade II and III gliomas who benefited from a preoperative 18F-FDG positron emission tomography (PET). Immunohistochemical expression of Hypoxia Inducible Factor-1alpha (HIF-1α), Carbonic Anhydrase IX (CAIX), Glucose Transporter 1 (GLUT1) and Caspase 3 active form (CASP3) along with the R132HIDH1 mutation was assessed in all cases as well as 1p/19q deletion status and p53 expression. HIF-1α expression was found in 15% of IDH-mutated compared to 7.7% of IDH-nonmutated tumors (P = 0.954). Also, GLUT-1 positive staining was found in 5% of IDH-mutated and in 7.1% of IDH-nonmutated tumors (P = 0.794). Finally, CA-IX expression was found in 15% of IDH-mutated and in 7.7% of IDH-nonmutated tumors (P = 0.484). The combined expression of these three hypoxic markers was found in two WHO grade III tumors, one of which was IDH-mutated whereas the other was IDH-nonmutated (P = 0.794). In IDH-mutated tumors, the median SUVmax ratio was 2.24 versus 2.15 in IDH-nonmutated tumors (P = 0.775). Together, these data question the actual relationship between IDH mutation status and in vivo hypoxic biomarkers expression in WHO grade II and III gliomas.
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Metadaten
Titel
IDH mutation status impact on in vivo hypoxia biomarkers expression: new insights from a clinical, nuclear imaging and immunohistochemical study in 33 glioma patients
verfasst von
Philippe Metellus
Carole Colin
David Taieb
Eric Guedj
Isabelle Nanni-Metellus
Andre Maues de Paula
Cécile Colavolpe
Stephane Fuentes
Henry Dufour
Marylin Barrie
Olivier Chinot
L’Houcine Ouafik
Dominique Figarella-Branger
Publikationsdatum
01.12.2011
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 3/2011
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-011-0625-2

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