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01.09.2007

Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis

verfasst von: J. Cobb Scott, Steven Paul Woods, Georg E. Matt, Rachel A. Meyer, Robert K. Heaton, J. Hampton Atkinson, Igor Grant

Erschienen in: Neuropsychology Review | Ausgabe 3/2007

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Abstract

This review provides a critical analysis of the central nervous system effects of acute and chronic methamphetamine (MA) use, which is linked to numerous adverse psychosocial, neuropsychiatric, and medical problems. A meta-analysis of the neuropsychological effects of MA abuse/dependence revealed broadly medium effect sizes, showing deficits in episodic memory, executive functions, information processing speed, motor skills, language, and visuoconstructional abilities. The neuropsychological deficits associated with MA abuse/dependence are interpreted with regard to their possible neural mechanisms, most notably MA-associated frontostriatal neurotoxicity. In addition, potential explanatory factors are considered, including demographics (e.g., gender), MA use characteristics (e.g., duration of abstinence), and the influence of common psychiatric (e.g., other substance-related disorders) and neuromedical (e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to the clinical management of persons with MA abuse/dependence.

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Titel: Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis
verfasst von: J. Cobb Scott
Steven Paul Woods
Georg E. Matt
Rachel A. Meyer
Robert K. Heaton
J. Hampton Atkinson
Igor Grant
Publikationsdatum: 01.09.2007
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 3/2007
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-007-9031-0

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Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis

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