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Reviews in Endocrine and Metabolic Disorders

Erschienen in:

01.06.2015

The PTH-Vitamin D-FGF23 axis

verfasst von: Jenny E. Blau, Michael T. Collins

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 2/2015

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Abstract

Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. In this review, we discuss the genomic structure, and transcriptional, translational, and posttranslational regulation of FGF23. We describe its interaction with PTH and vitamin D, disorders of altered FGF23 states, and emerging therapies for diseases of FGF23 based upon these findings. This discussion helps redefine the role of PTH and vitamin D in relation to a complex bone-kidney-parathyroid loop, and points to areas within this complicated field in need of further clarification and research.

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Titel: The PTH-Vitamin D-FGF23 axis
verfasst von: Jenny E. Blau
Michael T. Collins
Publikationsdatum: 01.06.2015
Verlag: Springer US
Erschienen in: Reviews in Endocrine and Metabolic Disorders / Ausgabe 2/2015
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-015-9318-z

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