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Erschienen in:
01.02.2015 | Nephrology – Original Paper
C-terminal agrin fragment (CAF) as a serum biomarker for residual renal function in peritoneal dialysis patients
Erschienen in: International Urology and Nephrology | Ausgabe 2/2015
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Background
C-terminal agrin fragment (CAF, size 22 kDa) is a promising new biomarker for kidney function. This study evaluated the usefulness of CAF as a serum biomarker for residual renal function (RRF) in patients undergoing automated peritoneal dialysis (APD).
Patients and methods
Serum, urine and dialysate samples were obtained in 12 end-stage renal disease patients undergoing APD. Total, renal and peritoneal clearances were calculated for CAF, creatinine, blood urea nitrogen (BUN) and cystatin c. kt/V was computed, and RRF (in ml/min) was calculated as the arithmetic mean of creatinine and BUN clearance. Correlations between the biomarkers’ serum concentrations, clearances, kt/V and RRF were computed.
Results
Serum CAF concentrations were highly correlated with serum concentrations of creatinine (r = 0.806, p = 0.002), BUN (r = 0.727, p = 0.007), cystatin c (r = 0.839, p = 0.001) and inversely to 24-h urinary output (r = −0.669, p = 0.017). RRF was inversely correlated with serum concentrations of CAF, cystatin c and creatinine being highest for CAF (r = −0.734, p = 0.007) followed by cystatin c (r = −0.65, p = 0.022) and creatinine (r = −0.606, p = 0.037). Serum BUN was not significantly associated with RRF (r = −0.497, p = 0.101). Age, weight and gender did not significantly affect serum CAF concentrations.
Conclusion
Serum CAF provides a robust serum biomarker for RRF in peritoneal dialysis patients undergoing APD, possibly outperforming the value of conventional biomarkers.