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17.09.2019 | Nephrology - Original Paper

The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial

verfasst von: Theodora Oikonomaki, Marios Papasotiriou, Theodoros Ntrinias, Christina Kalogeropoulou, Petros Zabakis, Dimitra Kalavrizioti, Ioannis Papadakis, Dimitrios S. Goumenos, Evangelos Papachristou

Erschienen in: International Urology and Nephrology | Ausgabe 11/2019

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Abstract

Purpose

Vascular calcification (VC) is an independent risk factor for cardiovascular disease in hemodialysis patients while Matrix GLA protein (MGP) is one of the most potent inhibitors of VC and its activation is vitamin K dependent. The aim of this study is to investigate the role of oral vitamin K2 supplementation in the prevention of VC progression in haemodialysis patients.

Methods

We conducted a prospective randomized interventional study in patients on hemodialysis. Patients were randomly assigned to either receiving orally 200 μgr of vitamin K2 (vitamin K2/MK-7, Solgar) every day for 1 year or no treatment. Uncarboxylated MGP (uc-MGP) concentrations were quantified using ELISA at randomization, at 3 and at 12 months. Aortic calcification was evaluated using Agatston score after an abdominal computed tomography scan that was performed at the beginning and at 12 months of follow-up.

Results

There were 102 patients that were randomized. After 1 year of follow-up, 22 patients from the vitamin K2 group and 30 patients from the control group were included in the analysis. After 3 months of treatment, uc-MGP values remained unchanged in the vitK2 group but after 1 year were reduced by 47% (p = 0.005). Furthermore, uc-MGP at 1 year was increased by 12% in the control group. At 1 year, vitK2 group had significantly lower values of uc-MGP in comparison to controls (p = 0.03). Agatston score was increased significantly both in vitamin K2 and control group at 1 year with no difference between groups.

Conclusions

Oral administration of vitamin K2 in patients on haemodialysis reduced serum uc-MGP levels but did not have an effect in the progression of aortic calcification.

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Titel: The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial
verfasst von: Theodora Oikonomaki
Marios Papasotiriou
Theodoros Ntrinias
Christina Kalogeropoulou
Petros Zabakis
Dimitra Kalavrizioti
Ioannis Papadakis
Dimitrios S. Goumenos
Evangelos Papachristou
Publikationsdatum: 17.09.2019
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 11/2019
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-019-02275-2

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The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial