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Journal of Natural Medicines

Erschienen in:

01.01.2010 | Natural Resource Letter

Antiviral activities of diarylheptanoids against influenza virus in vitro

verfasst von: Rie Sawamura, Yi Sun, Ken Yasukawa, Tomomi Shimizu, Wataru Watanabe, Masahiko Kurokawa

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2010

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Abstract

The anti-influenza A/PR/8/34 (H1N1) virus activities of ten diarylheptanoids isolated from Alpinia officinarum were examined using the MTT method. The 50% inhibitory concentration of each diarylheptanoid examined was clearly lower than its 50% cytotoxic concentration determined by the MTT assay and/or maximum non-cytotoxic concentration (MNCC) determined by the morphological change of cells. In particular, the influenza virus was more susceptible to 7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-4E-hepten-3-one (3) and (5S)-5-hydroxy-7-(4″-hydroxyphenyl)-1-phenyl-3-heptanone (8) than the other diarylheptanoids. Thus, all diarylheptanoids exhibited potential antiviral activity against influenza virus in vitro.

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Titel: Antiviral activities of diarylheptanoids against influenza virus in vitro
verfasst von: Rie Sawamura
Yi Sun
Ken Yasukawa
Tomomi Shimizu
Wataru Watanabe
Masahiko Kurokawa
Publikationsdatum: 01.01.2010
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2010
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-009-0372-2

Springer Medizin

Abstract

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