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01.07.2014 | Original Paper

Inhibitory effects of juglanin on cellular senescence in human dermal fibroblasts

verfasst von: Hyo Hyun Yang, Kyoung Hwangbo, Ming Shan Zheng, Jong-Keun Son, Hwa Young Kim, Suk Hwan Baek, Hyung Chul Choi, So Young Park, Jae-Ryong Kim

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2014

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Abstract

Cellular senescence contributes to tissue and organismal aging, tumor suppression and progress, tissue repair and regeneration, and age-related diseases. Thus, aging intervention might be a promising target for treatment and prevention of diverse age-related diseases. In the present study, we investigated whether juglanin purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). Juglanin decreased senescence-associated β-galactosidase activity (SA-β-gal) and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. Juglanin also repressed SA-β-gal activity in HDFs under replicative senescence. These results suggest that juglanin represses cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that alleviate tissue aging or age-related diseases.

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Titel: Inhibitory effects of juglanin on cellular senescence in human dermal fibroblasts
verfasst von: Hyo Hyun Yang
Kyoung Hwangbo
Ming Shan Zheng
Jong-Keun Son
Hwa Young Kim
Suk Hwan Baek
Hyung Chul Choi
So Young Park
Jae-Ryong Kim
Publikationsdatum: 01.07.2014
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2014
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-014-0817-0

Springer Medizin

Abstract

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