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Open Access 07.03.2019 | Original Paper

Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds

verfasst von: Weicheng Wang, Yi Zhang, Souichi Nakashima, Seikou Nakamura, Tao Wang, Masayuki Yoshikawa, Hisashi Matsuda

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2019

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Abstract

The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition.

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Titel: Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
verfasst von: Weicheng Wang
Yi Zhang
Souichi Nakashima
Seikou Nakamura
Tao Wang
Masayuki Yoshikawa
Hisashi Matsuda
Publikationsdatum: 07.03.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-01276-2

Springer Medizin

Abstract

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