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Die Nephrologie

Erschienen in:

01.09.2006 | Leitthema

Pathogenese der fokal segmentalen Glomerulosklerose: eine Morphe, viele Erkrankungen

verfasst von: Dr. M. Schiffer

Erschienen in: Die Nephrologie | Ausgabe 3/2006

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Zusammenfassung

Die fokal segmentale Glomerulosklerose (FSGS) ist das histologische Korrelat verschiedenster Krankheitsprozesse, bei denen entweder ein primärer Podozytendefekt vorliegt oder es im Verlauf zu einer sekundären Mitschädigung des Glomerulus mit fortschreitendem Podozytenverlust kommt. Die klinischen Verläufe reichen von milder Proteinurie und guten therapeutischen Ansprechraten bis hin zu sehr aggressiven, therapieresistenten, nephrotischen Verlaufsformen, die rasch zur terminalen Niereninsuffizienz führen. Im Zentrum der Erkrankung steht der Podozyt. Diesem komplexen Zelltyp kommt eine Schlüsselstellung in der Aufrechterhaltung der normalen Struktur und Funktion des Glomerulus zu. Diese Übersicht fasst die wichtigsten bekannten Ursachen der FSGS-Entstehung zusammen. Das Verständnis der unterschiedlichen Pathomechanismen, die zu einer Podozytenschädigung führen, macht deutlich, dass bislang neue, zielgerichtete Strategien für die Prävention und Behandlung podozytärer Erkrankungen fehlen.

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Titel: Pathogenese der fokal segmentalen Glomerulosklerose: eine Morphe, viele Erkrankungen
verfasst von: Dr. M. Schiffer
Publikationsdatum: 01.09.2006
Verlag: Springer-Verlag
Erschienen in: Die Nephrologie / Ausgabe 3/2006
Print ISSN: 2731-7463
Elektronische ISSN: 2731-7471
DOI: https://doi.org/10.1007/s11560-006-0027-1

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