Skip to main content
Erschienen in: Journal of General Internal Medicine 9/2007

01.09.2007 | Original Article

How the Women’s Health Initiative (WHI) Influenced Physicians’ Practice and Attitudes

verfasst von: Terry M. Bush, PhD, Amy E. Bonomi, PhD, MPH, Larissa Nekhlyudov, MD, MPH, Evette J. Ludman, PhD, Susan D. Reed, MD, MPH, Maureen T. Connelly, MD, Lou C. Grothaus, MA, Andrea Z. LaCroix, PhD, Katherine M. Newton, PhD

Erschienen in: Journal of General Internal Medicine | Ausgabe 9/2007

Einloggen, um Zugang zu erhalten

Abstract

Background

The landmark Women’s Health Initiative (WHI) Postmenopausal Hormone Therapy Trial published in 2002 showed that the health risks of combination hormone therapy (HT) with estrogen and progestin outweighed the benefits in healthy postmenopausal women. Dissemination of results had a major impact on prescriptions for, and physician beliefs about HT. No study has fully examined the influence of the widely publicized WHI on physicians’ practice and attitudes or their opinions of the scientific evidence regarding HT; in addition, little is known about how physicians assist women in their decisions regarding HT.

Design and Participants

We conducted in-depth telephone interviews with family practitioners, internists, and gynecologists from integrated health care delivery systems in Washington State (n = 10 physicians) and Massachusetts (n = 12 physicians). Our objectives were to obtain qualitative information from these physicians to understand their perspectives on use of HT, the scientific evidence regarding its risks and benefits, and counseling strategies around HT use and discontinuation.

Approach

We used Template Analysis to code transcribed telephone interviews and identify themes.

Results

Physicians were conflicted about the WHI results and its implications. Seven themes identified from in-depth interviews suggested that the WHI (1) was a ground-breaking study that changed clinical practice, including counseling; (2) was not applicable to the full range of patients seen in clinical practice; (3) raised concerns over the impact of publicized health information on women; (4) created uncertainty about the risks and benefits of HT; (5) called for the use of decision aids; (6) influenced discontinuation strategies; and (7) provided an opportunity to discuss healthy lifestyle options with patients. As a result of the WHI, physicians reported they no longer prescribe HT for prevention and were more likely to suggest discontinuation, although many felt women should be in charge of the HT decision.

Conclusions

Physicians varied in their opinions of HT and the scientific evidence (positive and negative). Whereas the WHI delineated the risks and benefits of HT, physicians reported that decision aids are needed to guide discussions with women about menopause and HT. Better guidance at the time of WHI study publication might have been valuable to ensure best practices.
Literatur
1.
Zurück zum Zitat Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.PubMedCrossRef Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.PubMedCrossRef
2.
Zurück zum Zitat Haas JS, Kaplan CP, Gerstenberger EP, Kerlikowske K. Changes in the use of postmenopausal hormone therapy after the publication of clinical trial results. Ann Intern Med. 2004;140(3):184–8.PubMed Haas JS, Kaplan CP, Gerstenberger EP, Kerlikowske K. Changes in the use of postmenopausal hormone therapy after the publication of clinical trial results. Ann Intern Med. 2004;140(3):184–8.PubMed
3.
Zurück zum Zitat Hersh AL, Stefanick ML, Stafford RS. National use of postmenopausal hormone therapy: annual trends and response to recent evidence. JAMA. 2004;291(1):47–53.PubMedCrossRef Hersh AL, Stefanick ML, Stafford RS. National use of postmenopausal hormone therapy: annual trends and response to recent evidence. JAMA. 2004;291(1):47–53.PubMedCrossRef
4.
Zurück zum Zitat Kim N, Gross C, Curtis J, et al. The impact of clinical trials on the use of hormone replacement therapy. A population-based study. J Gen Intern Med. 2005;20(11):1026–31.PubMedCrossRef Kim N, Gross C, Curtis J, et al. The impact of clinical trials on the use of hormone replacement therapy. A population-based study. J Gen Intern Med. 2005;20(11):1026–31.PubMedCrossRef
5.
Zurück zum Zitat Buist DS, Newton KM, Miglioretti DL, et al. Hormone therapy prescribing patterns in the United States. Obstet Gynecol. 2004;104(5 Pt 1):1042–50.PubMed Buist DS, Newton KM, Miglioretti DL, et al. Hormone therapy prescribing patterns in the United States. Obstet Gynecol. 2004;104(5 Pt 1):1042–50.PubMed
6.
Zurück zum Zitat Machens K, Schmidt-Gollwitzer K. Issues to debate on the Women’s Health Initiative (WHI) study. Hormone replacement therapy: an epidemiological dilemma? Hum Reprod. 2003 Oct;18(10):1992–9.PubMedCrossRef Machens K, Schmidt-Gollwitzer K. Issues to debate on the Women’s Health Initiative (WHI) study. Hormone replacement therapy: an epidemiological dilemma? Hum Reprod. 2003 Oct;18(10):1992–9.PubMedCrossRef
7.
Zurück zum Zitat Hemminki E. Opposition to unpopular research results: Finnish professional reactions to the WHI findings. Health Policy. 2004;69(3):283–91.PubMedCrossRef Hemminki E. Opposition to unpopular research results: Finnish professional reactions to the WHI findings. Health Policy. 2004;69(3):283–91.PubMedCrossRef
8.
Zurück zum Zitat Lemay A. The relevance of the Women’s Health Initiative results on combined hormone replacement therapy in clinical practice. J Obstet Gynaecol Can. 2002;24(9):711–5.PubMed Lemay A. The relevance of the Women’s Health Initiative results on combined hormone replacement therapy in clinical practice. J Obstet Gynaecol Can. 2002;24(9):711–5.PubMed
9.
Zurück zum Zitat Kaplan B, Yogev Y, Orvieto R, Hirsch M, Fisher M, Rabinerson D. Effect of the WHI study on the attitude of Israeli gynecologists to hormonal therapy during menopause. Clin Exp Obstet Gynecol. 2004;31(4):267–8.PubMed Kaplan B, Yogev Y, Orvieto R, Hirsch M, Fisher M, Rabinerson D. Effect of the WHI study on the attitude of Israeli gynecologists to hormonal therapy during menopause. Clin Exp Obstet Gynecol. 2004;31(4):267–8.PubMed
10.
Zurück zum Zitat Williams RS, Christie D, Sistrom C. Assessment of the understanding of the risks and benefits of hormone replacement therapy (HRT) in primary care physicians. Am J Obstet Gynecol. 2005;193(2):551–6; discussion 556–8.PubMedCrossRef Williams RS, Christie D, Sistrom C. Assessment of the understanding of the risks and benefits of hormone replacement therapy (HRT) in primary care physicians. Am J Obstet Gynecol. 2005;193(2):551–6; discussion 556–8.PubMedCrossRef
11.
Zurück zum Zitat Ena G, Rozenberg S. Issues to debate on the Women’s Health Initiative (WHI) study. Prescription attitudes among Belgian gynecologists after premature discontinuation of the WHI study. Hum Reprod. 2003;18(11):2245–8.PubMedCrossRef Ena G, Rozenberg S. Issues to debate on the Women’s Health Initiative (WHI) study. Prescription attitudes among Belgian gynecologists after premature discontinuation of the WHI study. Hum Reprod. 2003;18(11):2245–8.PubMedCrossRef
12.
Zurück zum Zitat Power ML, Schulkin J, Rossouw JE. Evolving practice patterns and attitudes toward hormone therapy of obstetrician-gynecologists. Menopause. 2007;14(1):20–8.PubMedCrossRef Power ML, Schulkin J, Rossouw JE. Evolving practice patterns and attitudes toward hormone therapy of obstetrician-gynecologists. Menopause. 2007;14(1):20–8.PubMedCrossRef
13.
Zurück zum Zitat Brett AS, Carney PI, McKeown RE. Brief report: attitudes toward hormone therapy after the Women’s Health Initiative: a comparison of internists and gynecologists. J Gen Intern Med. 2005;20(5):416–8.PubMedCrossRef Brett AS, Carney PI, McKeown RE. Brief report: attitudes toward hormone therapy after the Women’s Health Initiative: a comparison of internists and gynecologists. J Gen Intern Med. 2005;20(5):416–8.PubMedCrossRef
14.
Zurück zum Zitat Sangi-Haghpeykar H, Poindexter AN III. Physicians’ views and practices concerning menopausal hormone therapy. Maturitas. 2007;56(1):30–7.PubMedCrossRef Sangi-Haghpeykar H, Poindexter AN III. Physicians’ views and practices concerning menopausal hormone therapy. Maturitas. 2007;56(1):30–7.PubMedCrossRef
15.
Zurück zum Zitat Nassar AH, Abd Essamad HM, Awwad JT, Khoury NG, Usta IM. Gynecologists' attitudes towards hormone therapy in the post “Women’s Health Initiative” study era. Maturitas. 2005;52(1):18–25.PubMedCrossRef Nassar AH, Abd Essamad HM, Awwad JT, Khoury NG, Usta IM. Gynecologists' attitudes towards hormone therapy in the post “Women’s Health Initiative” study era. Maturitas. 2005;52(1):18–25.PubMedCrossRef
16.
Zurück zum Zitat Blumel JE, Castelo-Branco C, Chedraui PA, et al. Patients’ and clinicians’ attitudes after the Women’s Health Initiative study. Menopause. 2004 28;11(1):57–61. Blumel JE, Castelo-Branco C, Chedraui PA, et al. Patients’ and clinicians’ attitudes after the Women’s Health Initiative study. Menopause. 2004 28;11(1):57–61.
17.
Zurück zum Zitat Lazar F Jr, Costa-Paiva L, Morais SS, Pedro AO, Pinto-Neto AM. The attitude of gynecologists in Sao Paulo, Brazil 3 years after the Women’s Health Initiative study. Maturitas. 2007;56(2):129–41.PubMedCrossRef Lazar F Jr, Costa-Paiva L, Morais SS, Pedro AO, Pinto-Neto AM. The attitude of gynecologists in Sao Paulo, Brazil 3 years after the Women’s Health Initiative study. Maturitas. 2007;56(2):129–41.PubMedCrossRef
18.
Zurück zum Zitat Kang BM, Kim MR, Park HM, et al. Attitudes of Korean clinicians to postmenopausal hormone therapy after the Women’s Health Initiative study. Menopause. 2006;13(1):125–9.PubMedCrossRef Kang BM, Kim MR, Park HM, et al. Attitudes of Korean clinicians to postmenopausal hormone therapy after the Women’s Health Initiative study. Menopause. 2006;13(1):125–9.PubMedCrossRef
19.
Zurück zum Zitat King N, Carroll C, Newton P, Dornan T. “You can’t cure it so you have to endure it”: the experience of adaptation to diabetic renal disease. Qual Health Res. 2002;12(3):329–46.PubMedCrossRef King N, Carroll C, Newton P, Dornan T. “You can’t cure it so you have to endure it”: the experience of adaptation to diabetic renal disease. Qual Health Res. 2002;12(3):329–46.PubMedCrossRef
20.
Zurück zum Zitat King, N. Template Analysis. In: Symon G, Canell C, eds. Qualitative methods in organizational research: a practical guide. London, England: Sage Publications; 1998:118–34. King, N. Template Analysis. In: Symon G, Canell C, eds. Qualitative methods in organizational research: a practical guide. London, England: Sage Publications; 1998:118–34.
21.
Zurück zum Zitat Gask L, Ludman E, Schaefer J. Qualitative study of an intervention for depression among patients with diabetes: how can we optimize patient–professional interaction? Chronic Illn. 2006;2(3):231–42.PubMed Gask L, Ludman E, Schaefer J. Qualitative study of an intervention for depression among patients with diabetes: how can we optimize patient–professional interaction? Chronic Illn. 2006;2(3):231–42.PubMed
22.
Zurück zum Zitat Diergaarde B, Bowen D, Ludman E, Culver J, Press N, Burke W. Genetic information: special or not? Responses from focus groups with members of a health maintenance organization. Am J Med Gen. 2007;143A:564–9.CrossRef Diergaarde B, Bowen D, Ludman E, Culver J, Press N, Burke W. Genetic information: special or not? Responses from focus groups with members of a health maintenance organization. Am J Med Gen. 2007;143A:564–9.CrossRef
23.
Zurück zum Zitat Kent G. Understanding the experiences of people with disfigurements: an integration of four models of social and psychological functioning. Psychol Health Med. 2000;5(2):117–29.CrossRef Kent G. Understanding the experiences of people with disfigurements: an integration of four models of social and psychological functioning. Psychol Health Med. 2000;5(2):117–29.CrossRef
24.
Zurück zum Zitat Crabtree BF, Miller WL. Using codes and code manuals: a template organizing style of interpretation. In: Crabtree BF, Miller WL, eds. Doing qualitative research. Newbury Park, Calif: Sage Publications; 1999. Crabtree BF, Miller WL. Using codes and code manuals: a template organizing style of interpretation. In: Crabtree BF, Miller WL, eds. Doing qualitative research. Newbury Park, Calif: Sage Publications; 1999.
25.
Zurück zum Zitat Connelly MT, Ferrari N, Hagen N, Inui TS. Patient-identified needs for hormone replacement therapy counseling: a qualitative study. Ann Intern Med. 1999;131(4):265–268.PubMed Connelly MT, Ferrari N, Hagen N, Inui TS. Patient-identified needs for hormone replacement therapy counseling: a qualitative study. Ann Intern Med. 1999;131(4):265–268.PubMed
26.
Zurück zum Zitat Anderson LA, Caplan LS, Buist DS, et al. Perceived barriers and recommendations concerning hormone replacement therapy counseling among primary care providers. Menopause. 1999;6(2):161–6.PubMedCrossRef Anderson LA, Caplan LS, Buist DS, et al. Perceived barriers and recommendations concerning hormone replacement therapy counseling among primary care providers. Menopause. 1999;6(2):161–6.PubMedCrossRef
27.
Zurück zum Zitat Newton KM, LaCroix AZ, Buist DS, Anderson LA, Delaney K. What factors account for hormone replacement therapy prescribing frequency? Maturitas. 2001;39(1):1–10.PubMedCrossRef Newton KM, LaCroix AZ, Buist DS, Anderson LA, Delaney K. What factors account for hormone replacement therapy prescribing frequency? Maturitas. 2001;39(1):1–10.PubMedCrossRef
28.
Zurück zum Zitat Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement study (HERS) Research Group. JAMA. 1998;280(7):605–13.PubMedCrossRef Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement study (HERS) Research Group. JAMA. 1998;280(7):605–13.PubMedCrossRef
29.
Zurück zum Zitat Haas JS, Geller B, Miglioretti DL, et al. Changes in newspaper coverage about hormone therapy with the release of new medical evidence. J Gen Intern Med. 2006;21(4):304–9.PubMedCrossRef Haas JS, Geller B, Miglioretti DL, et al. Changes in newspaper coverage about hormone therapy with the release of new medical evidence. J Gen Intern Med. 2006;21(4):304–9.PubMedCrossRef
30.
Zurück zum Zitat North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause. 2004;11(1):11–33.CrossRef North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause. 2004;11(1):11–33.CrossRef
Metadaten
Titel
How the Women’s Health Initiative (WHI) Influenced Physicians’ Practice and Attitudes
verfasst von
Terry M. Bush, PhD
Amy E. Bonomi, PhD, MPH
Larissa Nekhlyudov, MD, MPH
Evette J. Ludman, PhD
Susan D. Reed, MD, MPH
Maureen T. Connelly, MD
Lou C. Grothaus, MA
Andrea Z. LaCroix, PhD
Katherine M. Newton, PhD
Publikationsdatum
01.09.2007
Verlag
Springer-Verlag
Erschienen in
Journal of General Internal Medicine / Ausgabe 9/2007
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-007-0296-z

Weitere Artikel der Ausgabe 9/2007

Journal of General Internal Medicine 9/2007 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Bei Herzinsuffizienz muss „Eisenmangel“ neu definiert werden!

16.05.2024 Herzinsuffizienz Nachrichten

Bei chronischer Herzinsuffizienz macht es einem internationalen Expertenteam zufolge wenig Sinn, die Diagnose „Eisenmangel“ am Serumferritin festzumachen. Das Team schlägt vor, sich lieber an die Transferrinsättigung zu halten.

Herzinfarkt mit 85 – trotzdem noch intensive Lipidsenkung?

16.05.2024 Hypercholesterinämie Nachrichten

Profitieren nach einem akuten Myokardinfarkt auch Betroffene über 80 Jahre noch von einer intensiven Lipidsenkung zur Sekundärprävention? Um diese Frage zu beantworten, wurden jetzt Registerdaten aus Frankreich ausgewertet.

ADHS-Medikation erhöht das kardiovaskuläre Risiko

16.05.2024 Herzinsuffizienz Nachrichten

Erwachsene, die Medikamente gegen das Aufmerksamkeitsdefizit-Hyperaktivitätssyndrom einnehmen, laufen offenbar erhöhte Gefahr, an Herzschwäche zu erkranken oder einen Schlaganfall zu erleiden. Es scheint eine Dosis-Wirkungs-Beziehung zu bestehen.

Erstmanifestation eines Diabetes-Typ-1 bei Kindern: Ein Notfall!

16.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Manifestiert sich ein Typ-1-Diabetes bei Kindern, ist das ein Notfall – ebenso wie eine diabetische Ketoazidose. Die Grundsäulen der Therapie bestehen aus Rehydratation, Insulin und Kaliumgabe. Insulin ist das Medikament der Wahl zur Behandlung der Ketoazidose.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.