nach oben

Journal of Cancer Survivorship

Erschienen in:

10.08.2018

Comorbid conditions and health-related quality of life in long-term cancer survivors—associations with demographic and medical characteristics

verfasst von: Heide Götze, Sabine Taubenheim, Andreas Dietz, Florian Lordick, Anja Mehnert

Erschienen in: Journal of Cancer Survivorship | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Our study provides a detailed overview of comorbid conditions and health-related quality of life of long-term cancer survivors and analyses the impact of demographic, disease- and treatment-related characteristics.

Methods

We present data obtained from 1000 survivors across mixed tumour entities 5 and 10 years after cancer diagnosis in a cross-sectional study. We analyse the prevalence of physical symptoms and health conditions via self-report and health-related quality of life using the EORTC QLQ-C30 in comparison to gender- and age-matched reference values of the general population.

Results

Cancer survivors reported on average 5 comorbidities; 23% had 7 or more comorbid conditions. Cancer survivors reported higher physical symptom burden than the population—especially fatigue, insomnia and pain. Type and prevalence of long-term and late effects differ with disease-related factors (e.g. cancer type, treatment) and characteristics of the patient. Cancer survivors also reported lower quality of life than the population, especially in everyday activities, social life, psychological well-being and financial difficulties. There was a positive association between high quality of life and a low level of morbidity.

Conclusions

The specific knowledge about physical long-term consequences for the individual types of cancer could raise awareness in health care professionals for high-risk patients and help to develop adequate prevention and survivorship-programs.

Implications for Cancer survivors

Limitations in the mental health area underlines the importance of psycho-oncological survivorship-care-plans, which go beyond the time of rehabilitation. Special attention should be given to the financial situation of patients in long-term follow-up care.

Nur mit Berechtigung zugänglich

Edwards BK, Noone A, Mariotto AB, Simard EP, Boscoe FP, Henley SJ, et al. Annual report to the nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer. 2014;120(9):1290–314.CrossRefPubMed

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–89.CrossRef

Bray F, Ren J, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132(5):1133–45.CrossRefPubMed

de Moor JS, Mariotto AB, Parry C, Alfano CM, Padgett L, Kent EE, et al. Cancer survivors in the United States: prevalence across the survivorship trajectory and implications for care. Cancer Epidemiol Biomark Prev. 2013;22(4):561–70.CrossRef

Arndt V, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A, Holleczek B, et al. Quality of life in long-term and very long-term cancer survivors versus population controls in Germany. Acta Oncol. 2017;56(2):190–7.CrossRefPubMed

Walsh K. Addressing psychosocial issues in cancer survivorship: past, present and future. Future Oncol. 2016;12(24):2823–34.CrossRefPubMed

Salz T, Baxi S. Moving survivorship care plans forward: focus on care coordination. Cancer Med. 2016;5(7):1717–22.CrossRefPubMedPubMedCentral

Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M. It’s not over when it’s over: long-term symptoms in cancer survivors—a systematic review. Int J Psychiatry Med. 2010;40(2):163–81.CrossRefPubMed

Hartung TJ, Brähler E, Faller H, Härter M, Hinz A, Johansen C, et al. The risk of being depressed is significantly higher in cancer patients than in the general population: prevalence and severity of depressive symptoms across major cancer types. Eur J Cancer. 2017;72:46–53.CrossRef

10.

Leach CR, Weaver KE, Aziz NM, Alfano CM, Bellizzi KM, Kent EE, et al. The complex health profile of long-term cancer survivors: prevalence and predictors of comorbid conditions. J Cancer Surviv. 2015;9(2):239–51.CrossRefPubMed

11.

Wu H, Harden JK. Symptom burden and quality of life in survivorship: a review of the literature. Cancer Nurs. 2015;38(1):E29–54.CrossRef

12.

Aziz NM. Cancer survivorship research: state of knowledge, challenges and opportunities. Acta Oncol. 2007;46(4):417–32.CrossRefPubMed

13.

Knowles G, Haigh R, McLean C, Phillips HA, Dunlop MG, Din FVN. Long term effect of surgery and radiotherapy for colorectal cancer on defecatory function and quality of life. Eur J Oncol Nurs. 2013;17(5):570–7.CrossRefPubMed

14.

Whitehead LC, Unahi K, Burrell B, Crowe MT. The experience of fatigue across long-term conditions: a qualitative meta-synthesis. J Pain Symptom Manag. 2016;52(1):131–143.e1.CrossRef

15.

Brearley SG, Stamataki Z, Addington-Hall J, Foster C, Hodges L, Jarrett N, et al. The physical and practical problems experienced by cancer survivors: a rapid review and synthesis of the literature. Eur J Oncol Nurs. 2011;15(3):204–12.CrossRefPubMed

16.

Savard J, Ivers H, Savard M, Morin CM. Cancer treatments and their side effects are associated with aggravation of insomnia: results of a longitudinal study. Cancer. 2015;121(10):1703–11.CrossRefPubMed

17.

Vissers PAJ, Thong MSY, Pouwer F, Zanders MMJ, Coebergh JWW, van de Poll-Franse LV. The impact of comorbidity on health-related quality of life among cancer survivors: analyses of data from the PROFILES registry. J Cancer Surviv. 2013;7(4):602–13.CrossRefPubMed

18.

Deimling GT, Arendt JA, Kypriotakis G, Bowman KF. Functioning of older, long-term cancer survivors: the role of cancer and comorbidities. J Am Geriatr Soc. 2009;57(Suppl 2):S289–92.CrossRefPubMed

19.

Ezendam NPM, Pijlman B, Bhugwandass C, Pruijt JFM, Mols F, Vos MC, et al. Chemotherapy-induced peripheral neuropathy and its impact on health-related quality of life among ovarian cancer survivors: results from the population-based PROFILES registry. Gynecol Oncol. 2014;135(3):510–7.CrossRefPubMed

20.

Weaver KE, Forsythe LP, Reeve BB, Alfano CM, Rodriguez JL, Sabatino SA, et al. Mental and physical health-related quality of life among U.S. cancer survivors: population estimates from the 2010 National Health Interview Survey. Cancer Epidemiol Biomark Prev. 2012;21(11):2108–17.CrossRef

21.

Braithwaite D, Moore DH, Satariano WA, Kwan ML, Hiatt RA, Kroenke C, et al. Prognostic impact of comorbidity among long-term breast cancer survivors: results from the LACE study. Cancer Epidemiol Biomark Prev. 2012;21(7):1115–25.CrossRef

22.

Husson O, Mols F, Ezendam NPM, Schep G, van de Poll-Franse LV. Health-related quality of life is associated with physical activity levels among colorectal cancer survivors: a longitudinal, 3-year study of the PROFILES registry. J Cancer Surviv. 2015;9(3):472–80.CrossRefPubMed

23.

Vissers PAJ, Martucci RB, Mols F, Bours MJL, Winkels RM, Kampman E, et al. The impact of body mass index and waist circumference on health-related quality of life among colorectal cancer survivors: results from the PROFILES registry. Nutr Cancer. 2017;69(8):1177–84.CrossRefPubMed

24.

Rowland JH, Kent EE, Forsythe LP, Loge JH, Hjorth L, Glaser A, et al. Cancer survivorship research in Europe and the United States: where have we been, where are we going, and what can we learn from each other? Cancer. 2013;119(Suppl 11):2094–108.CrossRefPubMedPubMedCentral

25.

van de Poll-Franse LV, Horevoorts N, van Eenbergen M, Denollet J, Roukema JA, Aaronson NK, et al. The patient reported outcomes following initial treatment and long term evaluation of survivorship registry: scope, rationale and design of an infrastructure for the study of physical and psychosocial outcomes in cancer survivorship cohorts. Eur J Cancer. 2011;47(14):2188–94.CrossRef

26.

Danese MD, O’Malley C, Lindquist K, Gleeson M, Griffiths RI. An observational study of the prevalence and incidence of comorbid conditions in older women with breast cancer. Ann Oncol. 2012;23(7):1756–65.CrossRefPubMed

27.

Hinz A, Singer S, Brähler E. European reference values for the quality of life questionnaire EORTC QLQ-C30: results of a German investigation and a summarizing analysis of six European general population normative studies. Acta Oncol. 2014;53(7):958–65.CrossRefPubMed

28.

Bayliss EA, Ellis JL, Steiner JF. Subjective assessments of comorbidity correlate with quality of life health outcomes: initial validation of a comorbidity assessment instrument. Health Qual Life Outcomes. 2005;3:51.CrossRefPubMedPubMedCentral

29.

Bayliss EA, Ellis JL, Steiner JF. Seniors’ self-reported multimorbidity captured biopsychosocial factors not incorporated into two other data-based morbidity measures. J Clin Epidemiol. 2009;62(5):550–7.e1.CrossRefPubMed

30.

Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–76.CrossRefPubMed

31.

VanderWalde A, Hurria A. Early breast cancer in the older woman. Clin Geriatr Med. 2012;28(1):73–91.CrossRefPubMed

32.

Avis NE, Deimling GT. Cancer survivorship and aging. Cancer. 2008;113(12 Suppl):3519–29.CrossRefPubMed

33.

Ness S, Kokal J, Fee-Schroeder K, Novotny P, Satele D, Barton D. Concerns across the survivorship trajectory: results from a survey of cancer survivors. Oncol Nurs Forum. 2013;40(1):35–42.CrossRefPubMed

34.

Romito F, Cormio C, Giotta F, Colucci G, Mattioli V. Quality of life, fatigue and depression in Italian long-term breast cancer survivors. Support Care Cancer. 2012;20(11):2941–8.CrossRefPubMed

35.

Goldstein D, Bennett BK, Webber K, Boyle F, de Souza PL, Wilcken NRC, et al. Cancer-related fatigue in women with breast cancer: outcomes of a 5-year prospective cohort study. J Clin Oncol. 2012;30(15):1805–12.CrossRefPubMed

36.

Bellury L, Pett MA, Ellington L, Beck SL, Clark JC, Stein KD. The effect of aging and cancer on the symptom experience and physical function of elderly breast cancer survivors. Cancer. 2012;118(24):6171–8.CrossRefPubMed

37.

Brant JM, Beck S, Dudley WN, Cobb P, Pepper G, Miaskowski C. Symptom trajectories in posttreatment cancer survivors. Cancer Nurs. 2011;34(1):67–77.CrossRefPubMed

38.

Husson O, Haak HR, Buffart LM, Nieuwlaat W, Oranje WA, Mols F, et al. Health-related quality of life and disease specific symptoms in long-term thyroid cancer survivors: a study from the population-based PROFILES registry. Acta Oncol. 2013;52(2):249–58.CrossRefPubMed

39.

Schmidt ME, Chang-Claude J, Seibold P, Vrieling A, Heinz J, Flesch-Janys D, et al. Determinants of long-term fatigue in breast cancer survivors: results of a prospective patient cohort study. Psychooncology. 2015;24(1):40–6.CrossRefPubMed

40.

Kent EE, Ambs A, Mitchell SA, Clauser SB, Smith AW, Hays RD. Health-related quality of life in older adult survivors of selected cancers: data from the SEER-MHOS linkage. Cancer. 2015;121(5):758–65.CrossRefPubMed

41.

LeMasters T, Madhavan S, Sambamoorthi U, Kurian S. A population-based study comparing HRQoL among breast, prostate, and colorectal cancer survivors to propensity score matched controls, by cancer type, and gender. Psychooncology. 2013;22(10):2270–82.PubMedPubMedCentral

42.

Faller H, Brahler E, Harter M, Keller M, Schulz H, Wegscheider K, et al. Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis. Psychooncology. 2015;24(11):1456–62.CrossRefPubMed

43.

Elliott J, Fallows A, Staetsky L, Smith PWF, Foster CL, Maher EJ, et al. The health and well-being of cancer survivors in the UK: findings from a population-based survey. Br J Cancer Suppl. 2011;105(Suppl 1):S11–20.CrossRef

44.

Mols F, Beijers T, Lemmens V, van den Hurk CJ, Vreugdenhil G, van de Poll-Franse LV. Chemotherapy-induced neuropathy and its association with quality of life among 2- to 11-year colorectal cancer survivors: results from the population-based PROFILES registry. J Clin Oncol. 2013;31(21):2699–707.CrossRefPubMed

Titel: Comorbid conditions and health-related quality of life in long-term cancer survivors—associations with demographic and medical characteristics
verfasst von: Heide Götze
Sabine Taubenheim
Andreas Dietz
Florian Lordick
Anja Mehnert
Publikationsdatum: 10.08.2018
Verlag: Springer US
Erschienen in: Journal of Cancer Survivorship / Ausgabe 5/2018
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-018-0708-6

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Comorbid conditions and health-related quality of life in long-term cancer survivors—associations with demographic and medical characteristics

Abstract

Purpose

Methods

Results

Conclusions

Implications for Cancer survivors

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Implications for Cancer survivors

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2018

Identifying barriers to cancer survivors sharing their survivorship care plans with their healthcare provider

Description, characterization, and evaluation of an online social networking community: the American Cancer Society’s Cancer Survivors Network®

The relationship between physical impairments, quality of life and disability of the neck and upper limb in patients following neck dissection

Impact of acculturation on breast cancer treatment and survivorship care among Mexican American patients in Texas

Long-term survivors of childhood cancer: cure and care—the Erice Statement (2006) revised after 10 years (2016)

Correction to: A systematic review of patient perspectives on surveillance after colorectal cancer treatment

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie