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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 5/2010

01.09.2010

The Role of Lipid Transfer Proteins in Allergic Diseases

verfasst von: Matthias Egger, Michael Hauser, Adriano Mari, Fatima Ferreira, Gabriele Gadermaier

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 5/2010

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Abstract

Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are considered true food allergens, and IgE reactivity to LTPs is often associated with severe systemic symptoms. Although Pru p 3 represents the predominant LTP in terms of patients’ IgE recognition, the contribution of pollen LTPs in primary sensitization cannot be ruled out. Due to structural homology, LTPs from different allergen sources are generally IgE cross-reactive. However, sensitization profiles among allergic patients are extremely heterogeneous, and individual cross-reactivity patterns can be restricted to a single LTP or encompass many different LTPs. Molecule-based approaches in allergy research and diagnosis are important for better understanding of LTP allergy and could assist clinicians with providing adequate patient-tailored advice.
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Metadaten
Titel
The Role of Lipid Transfer Proteins in Allergic Diseases
verfasst von
Matthias Egger
Michael Hauser
Adriano Mari
Fatima Ferreira
Gabriele Gadermaier
Publikationsdatum
01.09.2010
Verlag
Current Science Inc.
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 5/2010
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-010-0128-9

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