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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 1/2011

01.02.2011

The Impact of Vitamin D on Regulatory T Cells

verfasst von: Emma S. Chambers, Catherine M. Hawrylowicz

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 1/2011

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Abstract

Epidemiologic studies highlight the increasing prevalence of vitamin D deficiency and insufficiency and its association with an increased risk of autoimmune diseases and poor respiratory function, including asthma. These and additional studies have raised interest in the immunomodulatory properties of vitamin D beyond its well-established role in calcium homeostasis and bone health. Vitamin D has been shown to influence the function of cells intrinsic to innate and adaptive immunity. This review discusses recent evidence that vitamin D promotes—both directly and indirectly—regulatory or suppressor T-cell populations with the capacity to inhibit inappropriate immune responses that cause disease, suggesting that this property may in part underpin the epidemiologic findings.
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Metadaten
Titel
The Impact of Vitamin D on Regulatory T Cells
verfasst von
Emma S. Chambers
Catherine M. Hawrylowicz
Publikationsdatum
01.02.2011
Verlag
Current Science Inc.
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 1/2011
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-010-0161-8

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