Skip to main content
Erschienen in: Current Allergy and Asthma Reports 1/2014

01.01.2014 | AUTOIMMUNITY (TK TARRANT, SECTION EDITOR)

Noninfectious Immune-Mediated Uveitis and Ocular Inflammation

verfasst von: Jennifer Pan, Manuj Kapur, Rex McCallum

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 1/2014

Einloggen, um Zugang zu erhalten

Abstract

Noninfectious uveitis encompasses a diverse group of ocular inflammatory disorders that share an underlying immune etiology and may be associated with systemic disease or confined primarily to the eye. Uveitis is commonly classified by anatomical location of inflammation into anterior, intermediate, posterior, and panuveitis. The treatment of noninfectious uveitis consists of corticosteroids, immunosuppressive agents, and surgically placed steroid implants. We review the epidemiology, immunopathology, and clinical features of several noninfectious immune-mediated uveitides, including HLA-B27 acute anterior uveitis, juvenile idiopathic arthritis, intermediate uveitis, sarcoidosis, Behcet’s disease, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia, and white dot syndromes. We also discuss the stepwise approach to medical treatment of immune-mediated uveitis as well as the characteristics, safety, and efficacy of immunosuppressive agents used to treat ocular inflammatory disease.
Literatur
1.
Zurück zum Zitat Kempen JH, Altaweel MM, Holbrook JT, et al. Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the Multicenter Uveitis Steroid Treatment (MUST) Trial. Ophthalmology. 2011;118:1916–26.PubMedCentralPubMedCrossRef Kempen JH, Altaweel MM, Holbrook JT, et al. Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the Multicenter Uveitis Steroid Treatment (MUST) Trial. Ophthalmology. 2011;118:1916–26.PubMedCentralPubMedCrossRef
2.
Zurück zum Zitat Rothova A, Suttorp-van Schulten MS, Frits Treffers W, Kijlstra A. Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol. 1996;80:332–6.PubMedCrossRef Rothova A, Suttorp-van Schulten MS, Frits Treffers W, Kijlstra A. Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol. 1996;80:332–6.PubMedCrossRef
3.
Zurück zum Zitat Chang JH, McCluskey PJ, Fracs F, Wakefield D. Acute anterior uveitis and HLA-B27. Surv Ophthalmol. 2005;50:364–88.PubMedCrossRef Chang JH, McCluskey PJ, Fracs F, Wakefield D. Acute anterior uveitis and HLA-B27. Surv Ophthalmol. 2005;50:364–88.PubMedCrossRef
4.
Zurück zum Zitat Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of uveitis nomenclature (SUN) for reporting clinical data. -Results of the First International Workshop. Am J Ophthalmol. 2005;150:509–16. Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of uveitis nomenclature (SUN) for reporting clinical data. -Results of the First International Workshop. Am J Ophthalmol. 2005;150:509–16.
5.
Zurück zum Zitat D’Alessandro LP, Forster DJ, Rao NA. Anterior uveitis and hypopyon. Am J Ophthalmol. 1991;112(3):317–21.PubMed D’Alessandro LP, Forster DJ, Rao NA. Anterior uveitis and hypopyon. Am J Ophthalmol. 1991;112(3):317–21.PubMed
6.
Zurück zum Zitat Lyons JL, Rosenbaum JT. Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol. 1997;115:61.PubMedCrossRef Lyons JL, Rosenbaum JT. Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol. 1997;115:61.PubMedCrossRef
7.
Zurück zum Zitat Paiva ES, Macaluso DC, Edwards A, Rosenbaum JT. Characterisation of uveitis in patients with psoriatic arthritis. Ann Rheum Dis. 2000;59:67.PubMedCrossRef Paiva ES, Macaluso DC, Edwards A, Rosenbaum JT. Characterisation of uveitis in patients with psoriatic arthritis. Ann Rheum Dis. 2000;59:67.PubMedCrossRef
8.
Zurück zum Zitat Bayen H, Bayen MC, De Curzon HP, et al. Involvement of the posterior eye segment in HLA B27 (+) iridocyclitis. J Fr Ophthalmol. 1988;11:561–6. Bayen H, Bayen MC, De Curzon HP, et al. Involvement of the posterior eye segment in HLA B27 (+) iridocyclitis. J Fr Ophthalmol. 1988;11:561–6.
9.
Zurück zum Zitat Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008;58(1):15–25.PubMedCrossRef Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008;58(1):15–25.PubMedCrossRef
10.
Zurück zum Zitat Leak AM, Ansell BM, Burman SJ. Antinuclear antibody studies in juvenile chronic arthritis. Arch Dis Child. 1986;61:168–72.PubMedCrossRef Leak AM, Ansell BM, Burman SJ. Antinuclear antibody studies in juvenile chronic arthritis. Arch Dis Child. 1986;61:168–72.PubMedCrossRef
11.
Zurück zum Zitat Kotaniemi K, Savolainen A, Karma A, Aho K. Recent advances in uveitis of juvenile idiopathic arthritis. Surv Ophthalmol. 2003;48(5):489–502.PubMedCrossRef Kotaniemi K, Savolainen A, Karma A, Aho K. Recent advances in uveitis of juvenile idiopathic arthritis. Surv Ophthalmol. 2003;48(5):489–502.PubMedCrossRef
12.
Zurück zum Zitat Gregory 2nd AC, Kempen JH, Daniel E, Kacmaz RO, Foster CS, et al. Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. Ophthalmology. 2013;120:186–92.PubMedCentralPubMedCrossRef Gregory 2nd AC, Kempen JH, Daniel E, Kacmaz RO, Foster CS, et al. Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. Ophthalmology. 2013;120:186–92.PubMedCentralPubMedCrossRef
13.
Zurück zum Zitat Ophthalmologic examinations in children with juvenile rheumatoid arthritis. Pediatrics. 2006; 117(5):1843–1845. Ophthalmologic examinations in children with juvenile rheumatoid arthritis. Pediatrics. 2006; 117(5):1843–1845.
14.
Zurück zum Zitat Southward TR, Ryder CA. Ophthalmological screening in juvenile arthritis: should the frequency of screening be based on the risk of developing chronic iridocyclitis? Br J Rheumatol. 1992;31:633–4.CrossRef Southward TR, Ryder CA. Ophthalmological screening in juvenile arthritis: should the frequency of screening be based on the risk of developing chronic iridocyclitis? Br J Rheumatol. 1992;31:633–4.CrossRef
15.
Zurück zum Zitat Henderly DE, Haymond RS, Rao NA, Smith RE. The significance of the pars plana exudates in pars planitis. Am J Ophthalmol. 1987;103:669–71.PubMed Henderly DE, Haymond RS, Rao NA, Smith RE. The significance of the pars plana exudates in pars planitis. Am J Ophthalmol. 1987;103:669–71.PubMed
16.
Zurück zum Zitat David JI, Mittal KK, Nussenblatt RB. HLA in intermediate uveitis. Dev Ophthalmol. 1992;23:35–7. David JI, Mittal KK, Nussenblatt RB. HLA in intermediate uveitis. Dev Ophthalmol. 1992;23:35–7.
17.
Zurück zum Zitat Zein G, Berta A, Foster CS. Multiple sclerosis-associated uveitis. Ocul Immunol Inflamm. 2004;12:137.PubMedCrossRef Zein G, Berta A, Foster CS. Multiple sclerosis-associated uveitis. Ocul Immunol Inflamm. 2004;12:137.PubMedCrossRef
18.
Zurück zum Zitat Prieto JF, Dios E, Gutierrez JM, et al. Pars planitis: epidemiology, treatment, and association with multiple sclerosis. Ocul Immunol Inflamm. 2001;9:93.PubMedCrossRef Prieto JF, Dios E, Gutierrez JM, et al. Pars planitis: epidemiology, treatment, and association with multiple sclerosis. Ocul Immunol Inflamm. 2001;9:93.PubMedCrossRef
19.
Zurück zum Zitat Obenauf CD, Shaw HE, Sydnor CF, Klintworth GK. Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol. 1978;86:648.PubMed Obenauf CD, Shaw HE, Sydnor CF, Klintworth GK. Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol. 1978;86:648.PubMed
21.
Zurück zum Zitat Jabs DA, Johns CJ. Ocular involvement in chronic sarcoidosis. Am J Ophthalmol. 1986;102:297–301.PubMed Jabs DA, Johns CJ. Ocular involvement in chronic sarcoidosis. Am J Ophthalmol. 1986;102:297–301.PubMed
22.
Zurück zum Zitat Hegab S, Al-Mutawa S. Immunopathogenesis of Behcet’s disease. Clin Immunol. 2000;96:174–86.PubMedCrossRef Hegab S, Al-Mutawa S. Immunopathogenesis of Behcet’s disease. Clin Immunol. 2000;96:174–86.PubMedCrossRef
23.
Zurück zum Zitat Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease. Lancet 1990;335:1078. Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease. Lancet 1990;335:1078.
24.
25.
Zurück zum Zitat Atmaca LS. Fundus changes associated with Behçet's disease. Graefe's Arch Clin Exp Ophthalmol. 1989;227:340–4.CrossRef Atmaca LS. Fundus changes associated with Behçet's disease. Graefe's Arch Clin Exp Ophthalmol. 1989;227:340–4.CrossRef
26.
Zurück zum Zitat Masuda K, Inaba G, Mizushima II. A nationwide survey of Behcet’s disease in Japan. Jpn J Ophthalmol. 1974;19:278–85. Masuda K, Inaba G, Mizushima II. A nationwide survey of Behcet’s disease in Japan. Jpn J Ophthalmol. 1974;19:278–85.
27.
Zurück zum Zitat Okada AA, Goto H, Ohno S, Mochizuki M, Ocular Behçet's Disease Research Group Of Japan. Multicenter study of infliximab for refractory uveoretinitis in Behçet disease. Arch Ophthalmol. 2012;130(5):592–8.PubMedCrossRef Okada AA, Goto H, Ohno S, Mochizuki M, Ocular Behçet's Disease Research Group Of Japan. Multicenter study of infliximab for refractory uveoretinitis in Behçet disease. Arch Ophthalmol. 2012;130(5):592–8.PubMedCrossRef
28.
Zurück zum Zitat Rubsamen PE, Gass JD. Vogt-Koyanagi-Harada syndrome. Clinical course, therapy, and long-term visual outcome. Arch Ophthalmol. 1991;109:682.PubMedCrossRef Rubsamen PE, Gass JD. Vogt-Koyanagi-Harada syndrome. Clinical course, therapy, and long-term visual outcome. Arch Ophthalmol. 1991;109:682.PubMedCrossRef
29.
Zurück zum Zitat Zhang XY, Wang XM, Hu TS. Profiling human leukocyte antigens in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1992;113:567.PubMed Zhang XY, Wang XM, Hu TS. Profiling human leukocyte antigens in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1992;113:567.PubMed
30.
Zurück zum Zitat Snyder DA, Tessler HH. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1980;90:69–75.PubMed Snyder DA, Tessler HH. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1980;90:69–75.PubMed
31.
Zurück zum Zitat Moorthy RS, Inomata H, Rao NAL. Vogt-Koyanagi-Harada syndrome. Surv Ophthalmol. 1995;39:265–92.PubMedCrossRef Moorthy RS, Inomata H, Rao NAL. Vogt-Koyanagi-Harada syndrome. Surv Ophthalmol. 1995;39:265–92.PubMedCrossRef
32.
Zurück zum Zitat Duke-Elder S, Perkins ES. Sympathetic ophthalmitis, in Duke-Elder S: Diseases of the uveal tract. Mosby: St Louis; 1966. p. 558–93. Duke-Elder S, Perkins ES. Sympathetic ophthalmitis, in Duke-Elder S: Diseases of the uveal tract. Mosby: St Louis; 1966. p. 558–93.
33.
Zurück zum Zitat Rao NA, Forster DJ, Spalton DJ. Sympathetic ophthalmia. In: Podos SM, Yanoff M, editors. The uvea uveitis and intraocular neoplasms, vol. 2. USA: Mosby-Wolfe; 1995. p. 8.10–3. Chapter 8. Rao NA, Forster DJ, Spalton DJ. Sympathetic ophthalmia. In: Podos SM, Yanoff M, editors. The uvea uveitis and intraocular neoplasms, vol. 2. USA: Mosby-Wolfe; 1995. p. 8.10–3. Chapter 8.
34.
Zurück zum Zitat Kilmartin DJ, Dick AD, Forrester JV. Prospective surveillance of sympathetic ophthalmia in the UK and Republic of Ireland. Br J Ophthalmol. 2000;84:259–63.PubMedCrossRef Kilmartin DJ, Dick AD, Forrester JV. Prospective surveillance of sympathetic ophthalmia in the UK and Republic of Ireland. Br J Ophthalmol. 2000;84:259–63.PubMedCrossRef
35.
Zurück zum Zitat Watzke RC, Packer AJ, Folk JC, et al. Punctate inner choroidopathy. Am J Ophthalmol. 1984;98:572–84.PubMed Watzke RC, Packer AJ, Folk JC, et al. Punctate inner choroidopathy. Am J Ophthalmol. 1984;98:572–84.PubMed
36.
Zurück zum Zitat Schlaegel Jr TF. Eye histoplasmosis. Ann Ophthalmol. 1979;11:1645–54.PubMed Schlaegel Jr TF. Eye histoplasmosis. Ann Ophthalmol. 1979;11:1645–54.PubMed
37.
Zurück zum Zitat Gass JD. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968;80:177–85.PubMedCrossRef Gass JD. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968;80:177–85.PubMedCrossRef
38.
Zurück zum Zitat Sinan C, Thierry V, Jeffrey SR, Neil AB. Neurological manifestations of acute posterior multifocal placoid pigment epitheliopathy. Stroke. 1996;27:996–1001.CrossRef Sinan C, Thierry V, Jeffrey SR, Neil AB. Neurological manifestations of acute posterior multifocal placoid pigment epitheliopathy. Stroke. 1996;27:996–1001.CrossRef
39.
Zurück zum Zitat O’Halloran HS, Berger JR, Lee WB, et al. Acute multifocal placoid pigment epitheliopathy and central nervous system involvement. Nine new cases and a review of the literature. Ophthalmology. 2001;108:861–8.PubMedCrossRef O’Halloran HS, Berger JR, Lee WB, et al. Acute multifocal placoid pigment epitheliopathy and central nervous system involvement. Nine new cases and a review of the literature. Ophthalmology. 2001;108:861–8.PubMedCrossRef
40.
Zurück zum Zitat Palestine AG, Nussenblatt RB, Chan CC, et al. Histopathology of the subretinal fibrosis and uveitis syndrome. Ophthalmology. 1985;92:838–44.PubMedCrossRef Palestine AG, Nussenblatt RB, Chan CC, et al. Histopathology of the subretinal fibrosis and uveitis syndrome. Ophthalmology. 1985;92:838–44.PubMedCrossRef
41.
Zurück zum Zitat LeHoang P, Ozdemir N, Benhamou A, et al. HLA-A29.2 subtype associated with birdshot retinochoroidopathy. Am J Ophthalmol. 1992;113:33.PubMed LeHoang P, Ozdemir N, Benhamou A, et al. HLA-A29.2 subtype associated with birdshot retinochoroidopathy. Am J Ophthalmol. 1992;113:33.PubMed
42.
Zurück zum Zitat Durrani K, Zakka FR, Ahmed M, Memon M, Siddique SS, Foster CS. Systemic therapy with conventional and novel immunomodulatory agents for ocular inflammatory disease. Surv Ophthalmol. 2011;56(6):474–510.PubMedCrossRef Durrani K, Zakka FR, Ahmed M, Memon M, Siddique SS, Foster CS. Systemic therapy with conventional and novel immunomodulatory agents for ocular inflammatory disease. Surv Ophthalmol. 2011;56(6):474–510.PubMedCrossRef
43.
Zurück zum Zitat Jabs DA, Rosenbaum JT, Foster CS, et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am J Ophthalmol. 2000;130:492.PubMedCrossRef Jabs DA, Rosenbaum JT, Foster CS, et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am J Ophthalmol. 2000;130:492.PubMedCrossRef
44.
Zurück zum Zitat Miserocchi E, Modorati G, Foster CS. New treatments in noninfectious uveitis. Dev Ophthalmol Basel, Karger. 2012;51:1–6.CrossRef Miserocchi E, Modorati G, Foster CS. New treatments in noninfectious uveitis. Dev Ophthalmol Basel, Karger. 2012;51:1–6.CrossRef
45.
Zurück zum Zitat Heiligenhaus A, Miserocchi E, Heinz C, Gerloni V, Kotaniemi K. Treatment of severe uveitis associated with juvenile idiopathic arthritis with anti-CD20 monoclonal antibody (rituximab). Rheumatology. 2011;50:1390–4.PubMedCrossRef Heiligenhaus A, Miserocchi E, Heinz C, Gerloni V, Kotaniemi K. Treatment of severe uveitis associated with juvenile idiopathic arthritis with anti-CD20 monoclonal antibody (rituximab). Rheumatology. 2011;50:1390–4.PubMedCrossRef
46.
Zurück zum Zitat Foster CS, Vitale AT. Immunosuppressive chemotherapy. In: Foster CS, Vitale AT, editors. Diagnosis and treatment of uveitis. 1st ed. Philadelphia, PA: WB Saunders; 2002. p. 177–214. Foster CS, Vitale AT. Immunosuppressive chemotherapy. In: Foster CS, Vitale AT, editors. Diagnosis and treatment of uveitis. 1st ed. Philadelphia, PA: WB Saunders; 2002. p. 177–214.
48.
Zurück zum Zitat Sobrin L, Christen W, Foster CS. Mycophenolate mofetil after methotrexate failure or intolerance in the treatment of scleritis and uveitis. Ophthalmology. 2008;115:1416–21.PubMedCrossRef Sobrin L, Christen W, Foster CS. Mycophenolate mofetil after methotrexate failure or intolerance in the treatment of scleritis and uveitis. Ophthalmology. 2008;115:1416–21.PubMedCrossRef
49.
Zurück zum Zitat Fauc AS, Doppman JL, Wolff SM. Cyclophosphamide-induced remissions in advanced polyarteritis nodosa. Am J Med. 1978;64:890–4.CrossRef Fauc AS, Doppman JL, Wolff SM. Cyclophosphamide-induced remissions in advanced polyarteritis nodosa. Am J Med. 1978;64:890–4.CrossRef
50.
Zurück zum Zitat Fosdick WM, Parsons JL, Hill DF. Long-term cyclophosphamide therapy in rheumatoid arthritis. Arthritis Rheum. 1968;11:151–61.PubMedCrossRef Fosdick WM, Parsons JL, Hill DF. Long-term cyclophosphamide therapy in rheumatoid arthritis. Arthritis Rheum. 1968;11:151–61.PubMedCrossRef
51.
Zurück zum Zitat Martin-Suarez I, D’Cruz D, Mansoor M, et al. Immunosuppressive treatment in severe connective tissue diseases: effects of low dose intravenous cyclophosphamide. Ann Rhem Dis. 1997;56:481–7.CrossRef Martin-Suarez I, D’Cruz D, Mansoor M, et al. Immunosuppressive treatment in severe connective tissue diseases: effects of low dose intravenous cyclophosphamide. Ann Rhem Dis. 1997;56:481–7.CrossRef
53.
Zurück zum Zitat Murphy CC, Greiner K, Plskova J, et al. Cyclosporine vs tacrolimus therapy for posterior and intermediate uveitis. Arch Ophthalmol. 2005;123:634–41.PubMedCrossRef Murphy CC, Greiner K, Plskova J, et al. Cyclosporine vs tacrolimus therapy for posterior and intermediate uveitis. Arch Ophthalmol. 2005;123:634–41.PubMedCrossRef
54.
Zurück zum Zitat Braun J, Baraliakos X, Listing J, Sieper J. Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept. Arthritis Rheum. 2005;52:2447.PubMedCrossRef Braun J, Baraliakos X, Listing J, Sieper J. Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept. Arthritis Rheum. 2005;52:2447.PubMedCrossRef
55.
Zurück zum Zitat Suhler EB, Smith JR, Wertheim MS, et al. A prospective trial of infliximab therapy for refractory uveitis: preliminary safety and efficacy outcomes. Arch Ophthalmol. 2005;123:903.PubMedCrossRef Suhler EB, Smith JR, Wertheim MS, et al. A prospective trial of infliximab therapy for refractory uveitis: preliminary safety and efficacy outcomes. Arch Ophthalmol. 2005;123:903.PubMedCrossRef
56.
Zurück zum Zitat Kempen JH, Daniel E, Dunn JP, et al. Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study. BMJ. 2009;339:2480.CrossRef Kempen JH, Daniel E, Dunn JP, et al. Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study. BMJ. 2009;339:2480.CrossRef
57.
Zurück zum Zitat Okada AA, Goto H, Ohno S, Mochizuki M. Multicenter study of infliximab for refractory uveoretinitis in Behcet disease. Arch Ophthalmol. 2012;13:592–8. Okada AA, Goto H, Ohno S, Mochizuki M. Multicenter study of infliximab for refractory uveoretinitis in Behcet disease. Arch Ophthalmol. 2012;13:592–8.
58.
Zurück zum Zitat Miserocchi E, Pontikaki I, Modorati G, Gattinara M, Meroni PL, Gerloni V. Anti-CD 20 monoclonal antibody (rituximab) treatment for inflammatory ocular diseases. Autoimmun Rev. 2011;11(1):35–9.PubMedCrossRef Miserocchi E, Pontikaki I, Modorati G, Gattinara M, Meroni PL, Gerloni V. Anti-CD 20 monoclonal antibody (rituximab) treatment for inflammatory ocular diseases. Autoimmun Rev. 2011;11(1):35–9.PubMedCrossRef
Metadaten
Titel
Noninfectious Immune-Mediated Uveitis and Ocular Inflammation
verfasst von
Jennifer Pan
Manuj Kapur
Rex McCallum
Publikationsdatum
01.01.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 1/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-013-0409-1

Weitere Artikel der Ausgabe 1/2014

Current Allergy and Asthma Reports 1/2014 Zur Ausgabe

IMMUNE DEFICIENCY AND DYSREGULATION (DP HUSTON, SECTION EDITOR)

Emerging Role of Human Basophil Biology in Health and Disease

OCCUPATIONAL ALLERGIES (JA POOLE, SECTION EDITOR)

Irritant-Induced Asthma in the Workplace

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

HNO-Op. auch mit über 90?

16.04.2024 HNO-Chirurgie Nachrichten

Mit Blick auf das Risiko für Komplikationen nach elektiven Eingriffen im HNO-Bereich scheint das Alter der Patienten kein ausschlaggebender Faktor zu sein. Entscheidend ist offenbar, wie fit die Betroffenen tatsächlich sind.

Intrakapsuläre Tonsillektomie gewinnt an Boden

16.04.2024 Tonsillektomie Nachrichten

Gegenüber der vollständigen Entfernung der Gaumenmandeln hat die intrakapsuläre Tonsillektomie einige Vorteile, wie HNO-Fachleute aus den USA hervorheben. Sie haben die aktuelle Literatur zu dem Verfahren gesichtet.

Bilateraler Hörsturz hat eine schlechte Prognose

15.04.2024 Hörsturz Nachrichten

Die Mehrzahl der Menschen mit Hörsturz ist einseitig betroffen, doch auch ein beidseitiger Hörsturz ist möglich. Wie häufig solche Fälle sind und wie sich ihr Verlauf darstellt, hat eine HNO-Expertenrunde aus den USA untersucht.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.