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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 8/2014

01.08.2014 | ANAPHYLAXIS AND DRUG ALLERGY (DA KHAN AND M CASTELLS, SECTION EDITORS)

Perioperative Anaphylaxis

verfasst von: Violeta Régnier Galvão, Pedro Giavina-Bianchi, Mariana Castells

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 8/2014

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Abstract

Perioperative anaphylaxis is a life-threatening condition with an estimated prevalence of 1:3,500 to 1:20,000 procedures and a mortality rate of up to 9 %. Clinical presentation involves signs such as skin rash, urticaria, angioedema, bronchospasm, tachycardia, bradycardia, and hypotension. Prompt recognition and treatment is of utmost importance to the patient’s prognosis, since clinical deterioration can develop rapidly. Epinephrine is the main treatment drug, and its use should not be postponed, since delayed administration is associated with increased mortality. Elevated levels of serum tryptase help to confirm the diagnosis. The main agents involved in IgE-mediated perioperative anaphylaxis are neuromuscular blocking agents, latex, antibiotics, hypnotics, opioids, and colloids. Specific investigation should be conducted 4 to 6 weeks after the reaction and relies on skin tests, serum-specific IgE, and challenge procedures. This review aims to discuss the main aspects of perioperative anaphylaxis: risk factors, diagnosis, treatment, culprit agents, specific investigation, and preventive measures.
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Metadaten
Titel
Perioperative Anaphylaxis
verfasst von
Violeta Régnier Galvão
Pedro Giavina-Bianchi
Mariana Castells
Publikationsdatum
01.08.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 8/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-014-0452-6

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