Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 6/2015

01.06.2015 | Food Allergy (T Green, Section Editor)

Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases

verfasst von: Saman Sabounchi, Jenna Bollyky, Kari Nadeau

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2015

Einloggen, um Zugang zu erhalten

Abstract

There has been significant increase in the prevalence of atopy over the past decade that cannot be explained by genetic predisposition. Environmental factors including nutrition, the uterine environment, and lifestyle factors are known to play a role in gene expression through epigenetic modifications. In this article, we review the literature on the environmental impact on epigenetic modulation of atopic diseases including asthma, food allergy, eczema, and allergic rhinitis. Recent public release of epigenomic data for hundreds of human tissues provides a powerful resource for further investigation of the molecular basis of atopic diseases.
Literatur
1.
Jurakic Toncic R, Marinovic B. What is new and hot in genetics of human atopic dermatitis: shifting paradigms in the landscape of allergic skin diseases. Acta Dermatovenerol Croat ADC. 2014;22(4):313–5.
2.•
Prescott SL. Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol. 2013;131(1):23–30. Good article regarding importance of early life environmental factors on allergic disease.PubMed
3.
Runyon RS, Cachola LM, Rajeshuni N, Hunter T, Garcia M, Ahn R, et al. Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One. 2012;7(11), e48796.PubMedCentralPubMed
4.
Stefanowicz D, Hackett TL, Garmaroudi FS, Gunther OP, Neumann S, Sutanto EN, et al. DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children. PLoS One. 2012;7(9), e44213.PubMedCentralPubMed
5.
Soto-Ramirez N, Arshad SH, Holloway JW, Zhang H, Schauberger E, Ewart S, et al. The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years. Clin Epigenetics. 2013;5(1):1.PubMedCentralPubMed
6.
Breton CV, Siegmund KD, Joubert BR, Wang X, Qui W, Carey V, et al. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. PLoS One. 2014;9(6), e99716.PubMedCentralPubMed
7.
Morales E, Bustamante M, Vilahur N, Escaramis G, Montfort M, de Cid R, et al. DNA hypomethylation at ALOX12 is associated with persistent wheezing in childhood. Am J Respir Crit Care Med. 2012;185(9):937–43.PubMed
8.
Perera F, Tang WY, Herbstman J, Tang D, Levin L, Miller R, et al. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One. 2009;4(2), e4488.PubMedCentralPubMed
9.
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5'-UTR methylation and childhood asthma severity. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2012;42(11):1575–81.
10.
Luo Y, Zhou B, Zhao M, Tang J, Lu Q. Promoter demethylation contributes to TSLP overexpression in skin lesions of patients with atopic dermatitis. Clin Exp Dermatol. 2014;39(1):48–53.PubMed
11.
Isidoro-Garcia M, Sanz C, Garcia-Solaesa V, Pascual M, Pescador DB, Lorente F, et al. PTGDR gene in asthma: a functional, genetic, and epigenetic study. Allergy. 2011;66(12):1553–62.PubMed
12.
Pascual M, Suzuki M, Isidoro-Garcia M, Padron J, Turner T, Lorente F, et al. Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma. Epigenetics Off J DNA Methylation Soc. 2011;6(9):1131–7.
13.
Kim YJ, Park SW, Kim TH, Park JS, Cheong HS, Shin HD, et al. Genome-wide methylation profiling of the bronchial mucosa of asthmatics: relationship to atopy. BMC Med Genet. 2013;14:39.PubMedCentralPubMed
14.
Joubert BR, Haberg SE, Nilsen RM, Wang X, Vollset SE, Murphy SK, et al. 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012;120(10):1425–31.PubMedCentralPubMed
15.
Reinius LE, Gref A, Saaf A, Acevedo N, Joerink M, Kupczyk M, et al. DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors. PLoS One. 2013;8(1), e53877.PubMedCentralPubMed
16.
Michel S, Busato F, Genuneit J, Pekkanen J, Dalphin JC, Riedler J, et al. Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy. Allergy. 2013;68(3):355–64.PubMed
17.
Slaats GG, Reinius LE, Alm J, Kere J, Scheynius A, Joerink M. DNA methylation levels within the CD14 promoter region are lower in placentas of mothers living on a farm. Allergy. 2012;67(7):895–903.PubMed
18.
Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, et al. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-gamma in T effector cells and Foxp3 in T regulatory cells in children. Clin Epigenetics. 2012;4(1):17.PubMedCentralPubMed
19.
Tang WY, Levin L, Talaska G, Cheung YY, Herbstman J, Tang D, et al. Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-gamma in cord white blood cells. Environ Health Perspect. 2012;120(8):1195–200.PubMedCentralPubMed
20.
Rossnerova A, Tulupova E, Tabashidze N, Schmuczerova J, Dostal M, Rossner Jr P, et al. Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments. Mutat Res. 2013;741–742:18–26.PubMed
21.
Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, et al. Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol. 2010;126(4):845–52. e10.PubMed
22.
Breton CV, Salam MT, Wang X, Byun HM, Siegmund KD, Gilliland FD. Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease. Environ Health Perspect. 2012;120(9):1320–6.PubMedCentralPubMed
23.
Brunst KJ, Leung YK, Ryan PH, Khurana Hershey GK, Levin L, Ji H, et al. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 2013;131(2):592–4. e1-3.PubMedCentralPubMed
24.
Tarantini L, Bonzini M, Apostoli P, Pegoraro V, Bollati V, Marinelli B, et al. Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect. 2009;117(2):217–22.PubMedCentralPubMed
25.
Munthe-Kaas MC, Bertelsen RJ, Torjussen TM, Hjorthaug HS, Undlien DE, Lyle R, et al. Pet keeping and tobacco exposure influence CD14 methylation in childhood. Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol. 2012;23(8):747–54.
26.
Miozzo M, Vaira V, Sirchia SM. Epigenetic alterations in cancer and personalized cancer treatment. Future Oncol (London, England). 2015;11(2):333–48.
27.
Sharon Chinthrajah KV, Morvarid Tavassoli, Kari CNadeau, Global Atlas of Allergy 2014.
28.
Fatemi M, Pao MM, Jeong S, Gal-Yam EN, Egger G, Weisenberger DJ, et al. Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level. Nucleic Acids Res. 2005;33(20), e176.PubMedCentralPubMed
29.
Szulwach KE, Jin P. Integrating DNA methylation dynamics into a framework for understanding epigenetic codes. BioEssays News Rev Mol Cell Dev Biol. 2014;36(1):107–17.
30.
Holliday R. DNA methylation and epigenetic inheritance. Philos Trans R Soc Lond Ser B Biol Sci. 1990;326(1235):329–38.
31.••
Harb H, Renz H. Update on epigenetics in allergic disease. J Allergy Clin Immunol. 2015;135(1):15–24. A recent article about different environmental factors effecting epigenetics in allergic disease.PubMed
32.
Weissmann F, Lyko F. Cooperative interactions between epigenetic modifications and their function in the regulation of chromosome architecture. BioEssays News Rev Mol Cell Dev Biol. 2003;25(8):792–7.
33.
Sadakierska-Chudy A, Filip M. A comprehensive view of the epigenetic landscape. Part II: histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs. Neurotox Res. 2015;27(2):172–97.PubMedCentralPubMed
34.
Dan J, Yang J, Liu Y, Xiao A, Liu L. Roles for histone acetylation in regulation of telomere elongation and two-cell state in mouse es cells. J Cell Physiol. 2015.
35.
Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012;13(5):343–57.PubMedCentralPubMed
36.
Tsuji G, Okiyama N, Villarroel VA, Katz SI. Histone deacetylase 6 inhibition impairs effector CD8 T-cell functions during skin inflammation. J Allergy Clin Immunol. 2014.
37.
Avni O, Lee D, Macian F, Szabo SJ, Glimcher LH, Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol. 2002;3(7):643–51.PubMed
38.
Wang JW, Li K, Hellermann G, Lockey RF, Mohapatra S, Mohapatra S. Regulating the regulators: microRNA and asthma. World Allergy Organ J. 2011;4(6):94–103.PubMedCentralPubMed
39.
Davalos V, Esteller M. MicroRNAs and cancer epigenetics: a macrorevolution. Curr Opin Oncol. 2010;22(1):35–45.PubMed
40.
Saito Y, Saito H, Liang G, Friedman JM. Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review. Clin Rev Allergy Immunol. 2014;47(2):128–35.PubMed
41.
Robinson DS. The role of the T cell in asthma. J Allergy Clin Immunol. 2010;126(6):1081–91. quiz 92–3.PubMed
42.
Lovinsky-Desir S, Ridder R, Torrone D, Maher C, Narula S, Scheuerman M, et al. DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics. Clin Epigenetics. 2014;6(1):9.PubMedCentralPubMed
43.
Tindemans I, Serafini N, Di Santo JP, Hendriks RW. GATA-3 function in innate and adaptive immunity. Immunity. 2014;41(2):191–206.PubMed
44.
Kwon NH, Kim JS, Lee JY, Oh MJ, Choi DC. DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma. J Clin Immunol. 2008;28(2):139–46.PubMed
45.
Scheinman EJ, Avni O. Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor. J Biol Chem. 2009;284(5):3037–48.PubMed
46.••
Begin P, Nadeau KC. Epigenetic regulation of asthma and allergic disease. Allergy Asthma Clin Immunol Off J Can Soc Allergy Clin Immunol. 2014;10(1):27. Very good review of articles about various epigenetic mechanisms in asthma and allergic disease.
47.
Zhang Y, Maksimovic J, Naselli G, Qian J, Chopin M, Blewitt ME, et al. Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells. Blood. 2013;122(16):2823–36.PubMedCentralPubMed
48.
Passerini L, Santoni de Sio FR, Roncarolo MG, Bacchetta R. Forkhead box P3: the peacekeeper of the immune system. Int Rev Immunol. 2014;33(2):129–45.PubMed
49.•
Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature. 2010;463(7282):808–12. Good article regarding importance of Foxp3 on regulatory T cell.PubMedCentralPubMed
50.
Kim HP, Leonard WJ. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med. 2007;204(7):1543–51.PubMedCentralPubMed
51.
Ogawa C, Tone Y, Tsuda M, Peter C, Waldmann H, Tone M. TGF-beta-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2. J Immunol (Baltimore, Md : 1950). 2014;192(1):475–83.PubMedCentral
52.
Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, et al. DNA methylation controls Foxp3 gene expression. Eur J Immunol. 2008;38(6):1654–63.PubMed
53.
Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 2014;158(4):749–63.PubMed
54.
Lim RH, Kobzik L, Dahl M. Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PLoS One. 2010;5(4), e10134.PubMedCentralPubMed
55.
Hollingsworth JW, Maruoka S, Boon K, Garantziotis S, Li Z, Tomfohr J, et al. In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Investig. 2008;118(10):3462–9.PubMedCentralPubMed
56.
Prescott S, Saffery R. The role of epigenetic dysregulation in the epidemic of allergic disease. Clin Epigenetics. 2011;2(2):223–32.PubMedCentralPubMed
57.
Schaub B, Liu J, Hoppler S, Schleich I, Huehn J, Olek S, et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol. 2009;123(4):774–82. e5.PubMed
58.
Noverr MC, Huffnagle GB. The ‘microflora hypothesis’ of allergic diseases. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2005;35(12):1511–20.
59.
Schroder PC, Li J, Wong GW, Schaub B. The rural–urban enigma of allergy: what can we learn from studies around the world? Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol. 2015;26(2):95–102.
60.
Horak E, Morass B, Ulmer H, Genuneit J, Braun-Fahrlander C, von Mutius E. Prevalence of wheezing and atopic diseases in Austrian schoolchildren in conjunction with urban, rural or farm residence. Wien Klin Wochenschr. 2014;126(17–18):532–6.PubMed
61.
Genuneit J. Exposure to farming environments in childhood and asthma and wheeze in rural populations: a systematic review with meta-analysis. Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol. 2012;23(6):509–18.
62.
Lluis A, Depner M, Gaugler B, Saas P, Casaca VI, Raedler D, et al. Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood. J Allergy Clin Immunol. 2014;133(2):551–9.PubMed
63.
Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211–21.PubMedCentralPubMed
64.
Acevedo N, Reinius LE, Greco D, Gref A, Orsmark-Pietras C, Persson H, et al. Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus. Hum Mol Genet. 2015;24(3):875–90.PubMedCentralPubMed
65.
Brauner EV, Loft S, Raaschou-Nielsen O, Vogel U, Andersen PS, Sorensen M. Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze. Genes Immun. 2012;13(1):94–7.PubMed
66.
Schieck M, Sharma V, Michel S, Toncheva AA, Worth L, Potaczek DP, et al. A polymorphism in the TH 2 locus control region is associated with changes in DNA methylation and gene expression. Allergy. 2014;69(9):1171–80.PubMed
67.
Leavy O. Asthma and allergy: prenatal protection through TLRs. Nat Rev Immunol. 2010;10(1):8–9.
68.
Conrad ML, Ferstl R, Teich R, Brand S, Blumer N, Yildirim AO, et al. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J Exp Med. 2009;206(13):2869–77.PubMedCentralPubMed
69.
Brand S, Teich R, Dicke T, Harb H, Yildirim AO, Tost J, et al. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol. 2011;128(3):618–25. e1-7.PubMed
70.
Turunen R, Koistinen A, Vuorinen T, Arku B, Soderlund-Venermo M, Ruuskanen O, et al. The first wheezing episode: respiratory virus etiology, atopic characteristics, and illness severity. Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol. 2014;25(8):796–803.
71.
McErlean P, Favoreto Jr S, Costa FF, Shen J, Quraishi J, Biyasheva A, et al. Human rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects. BMC Med Genet. 2014;7:37.
72.
Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, et al. Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2014;44(1):102–12.
73.
Foolad N, Brezinski EA, Chase EP, Armstrong AW. Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids. JAMA Dermatol. 2013;149(3):350–5.PubMed
74.
Elazab N, Mendy A, Gasana J, Vieira ER, Quizon A, Forno E. Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials. Pediatrics. 2013;132(3):e666–76.PubMed
75.
Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): probiotics. World Allergy Organ J. 2015;8(1):4.PubMedCentralPubMed
76.
Berni Canani R, Nocerino R, Terrin G, Coruzzo A, Cosenza L, Leone L, et al. Effect of Lactobacillus GG on tolerance acquisition in infants with cow’s milk allergy: a randomized trial. J Allergy Clin Immunol. 2012;129(2):580–2. 2.e1-5.PubMed
77.
Schiavi E, Barletta B, Butteroni C, Corinti S, Boirivant M, Di Felice G. Oral therapeutic administration of a probiotic mixture suppresses established Th2 responses and systemic anaphylaxis in a murine model of food allergy. Allergy. 2011;66(4):499–508.PubMed
78.
Tang ML, Ponsonby AL, Orsini F, Tey D, Robinson M, Su EL, et al. Administration of a probiotic with peanut oral immunotherapy: a randomized trial. J Allergy Clin Immunol. 2015;135(3):737–44.PubMed
79.
Molter A, Agius RM, de Vocht F, Lindley S, Gerrard W, Lowe L, et al. Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort. Environ Health Perspect. 2013;121(10):1232–8.PubMedCentralPubMed
80.
Klingbeil EC, Hew KM, Nygaard UC, Nadeau KC. Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma. Immunol Res. 2014;58(2–3):369–73.PubMedCentralPubMed
81.
Gaffin JM, Kanchongkittiphon W, Phipatanakul W. Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis. Int Immunopharmacol. 2014;22(1):21–30.PubMedCentralPubMed
82.
Burke H, Leonardi-Bee J, Hashim A, Pine-Abata H, Chen Y, Cook DG, et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis. Pediatrics. 2012;129(4):735–44.PubMed
83.
Rehan VK, Liu J, Naeem E, Tian J, Sakurai R, Kwong K, et al. Perinatal nicotine exposure induces asthma in second generation offspring. BMC Med. 2012;10:129.PubMedCentralPubMed
84.
Li YF, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest. 2005;127(4):1232–41.PubMed
85.
Murphy SK, Hollingsworth JW. Stress: a possible link between genetics, epigenetics, and childhood asthma. Am J Respir Crit Care Med. 2013;187(6):563–4.PubMedCentralPubMed
86.
Suter M, Abramovici A, Showalter L, Hu M, Shope CD, Varner M, et al. In utero tobacco exposure epigenetically modifies placental CYP1A1 expression. Metab Clin Exp. 2010;59(10):1481–90.PubMedCentralPubMed
87.
Dominguez-Salas P, Cox SE, Prentice AM, Hennig BJ, Moore SE. Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc. 2012;71(1):154–65.PubMedCentralPubMed
88.
Martinussen MP, Risnes KR, Jacobsen GW, Bracken MB. Folic acid supplementation in early pregnancy and asthma in children aged 6 years. Am J Obstet Gynecol. 2012;206(1):72. e1-7.PubMedCentralPubMed
89.
Barua S, Kuizon S, Junaid MA. Folic acid supplementation in pregnancy and implications in health and disease. J Biomed Sci. 2014;21:77.PubMedCentralPubMed
90.
McGarel C, Pentieva K, Strain JJ, McNulty H. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc. 2015;74(1):46–55.PubMed
91.
Yang L, Jiang L, Bi M, Jia X, Wang Y, He C, et al. High dose of maternal folic acid supplementation is associated to infant asthma. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc. 2015;75:88–93.
92.
Zetstra-van der Woude PA, De Walle HE, Hoek A, Bos HJ, Boezen HM, Koppelman GH, et al. Maternal high-dose folic acid during pregnancy and asthma medication in the offspring. Pharmacoepidemiol Drug Saf. 2014;23(10):1059–65.PubMed
93.
Bekkers MB, Elstgeest LE, Scholtens S, Haveman-Nies A, de Jongste JC, Kerkhof M, et al. Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy. Eur Respir J. 2012;39(6):1468–74.PubMed
94.
Yamaguchi Y, Takamura H, Tada Y, Akagi T, Oyama K, Miyashita T, et al. Nanog positively regulates Zfp57 expression in mouse embryonic stem cells. Biochem Biophys Res Commun. 2014;453(4):817–20.PubMed
95.
Amarasekera M, Martino D, Ashley S, Harb H, Kesper D, Strickland D et al. Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans. FASEB J Off Publ Fed Am Soc Exp Biol. 2014.
96.
Kremmyda LS, Vlachava M, Noakes PS, Diaper ND, Miles EA, Calder PC. Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review. Clin Rev Allergy Immunol. 2011;41(1):36–66.PubMed
97.
Netting MJ, Middleton PF, Makrides M. Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches. Nutrition (Burbank, Los Angeles County, Calif). 2014;30(11–12):1225–41.
98.
Miles EA, Calder PC. Omega-6 and omega-3 polyunsaturated fatty acids and allergic diseases in infancy and childhood. Curr Pharm Des. 2014;20(6):946–53.PubMed
99.
Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, et al. Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. BMJ (Clin Res Ed). 2012;344:e184.
100.
Adkins Y, Kelley DS. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem. 2010;21(9):781–92.PubMed
101.
Xue B, Yang Z, Wang X, Shi H. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS One. 2012;7(10), e45990.PubMedCentralPubMed
102.
Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem. 2010;285(25):19051–9.PubMedCentralPubMed
103.
Shek LP, Chong MF, Lim JY, Soh SE, Chong YS. Role of dietary long-chain polyunsaturated fatty acids in infant allergies and respiratory diseases. Clin Dev Immunol. 2012;2012:730568.PubMedCentralPubMed
104.
Bildstrup L, Backer V, Thomsen SF. Increased body mass index predicts severity of asthma symptoms but not objective asthma traits in a large sample of asthmatics. J Asthma Off J Assoc Care Asthma. 2015:1–22.
105.
Silveira DH, Zhang L, Prietsch SO, Vecchi AA, Susin LR. Association between dietary habits and asthma severity in children. Indian Pediatr. 2015;52(1):25–30.PubMed
106.
Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology. 2010;151(10):4756–64.PubMedCentralPubMed
107.
Rastogi D, Suzuki M, Greally JM. Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Sci Rep. 2013;3:2164.PubMedCentralPubMed
108.
Williams DR, Sternthal M, Wright RJ. Social determinants: taking the social context of asthma seriously. Pediatrics. 2009;123 Suppl 3:S174–84.PubMedCentralPubMed
109.
Cohen RT, Canino GJ, Bird HR, Celedon JC. Violence, abuse, and asthma in Puerto Rican children. Am J Respir Crit Care Med. 2008;178(5):453–9.PubMedCentralPubMed
110.
Chen W, Boutaoui N, Brehm JM, Han YY, Schmitz C, Cressley A, et al. ADCYAP1R1 and asthma in Puerto Rican children. Am J Respir Crit Care Med. 2013;187(6):584–8.PubMedCentralPubMed
111.
Lange NE, Bunyavanich S, Silberg JL, Canino G, Rosner BA, Celedon JC. Parental psychosocial stress and asthma morbidity in Puerto Rican twins. J Allergy Clin Immunol. 2011;127(3):734–40. e1-7.PubMedCentralPubMed
112.
Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, et al. Integrative analysis of 111 reference human epigenomes. Nature. 2015;518(7539):317–30.PubMed
Metadaten
Titel
Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases
verfasst von
Saman Sabounchi
Jenna Bollyky
Kari Nadeau
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 6/2015
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-015-0533-1

Weitere Artikel der Ausgabe 6/2015

Current Allergy and Asthma Reports 6/2015 Zur Ausgabe

Immunotherapy and Immunomodulators (B Vickery, Section Editor)

An Examination of Clinical and Immunologic Outcomes in Food Allergen Immunotherapy by Route of Administration

Asthma (WJ Calhoun and S Peters, Section Editors)

Asthma is Different in Women

Rhinosinusitis (J Mullol, Section Editor)

Remodeling and Repair in Rhinosinusitis

Allergic Skin Diseases (L Fonacier, Section Editor)

Urticaria Guidelines: Consensus and Controversies in the European and American Guidelines

Autoimmunity (TK Tarrant, Section Editor)

IgG4-Related Ophthalmic Disease: Pooling of Published Cases and Literature Review

Allergic Skin Diseases (L Fonacier, Section Editor)

The Other Itch That Rashes: a Clinical and Therapeutic Approach to Pruritus and Skin Picking Disorders

Neu im Fachgebiet HNO

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

HNO-Op. auch mit über 90?

16.04.2024 HNO-Chirurgie Nachrichten

Mit Blick auf das Risiko für Komplikationen nach elektiven Eingriffen im HNO-Bereich scheint das Alter der Patienten kein ausschlaggebender Faktor zu sein. Entscheidend ist offenbar, wie fit die Betroffenen tatsächlich sind.

Intrakapsuläre Tonsillektomie gewinnt an Boden

16.04.2024 Tonsillektomie Nachrichten

Gegenüber der vollständigen Entfernung der Gaumenmandeln hat die intrakapsuläre Tonsillektomie einige Vorteile, wie HNO-Fachleute aus den USA hervorheben. Sie haben die aktuelle Literatur zu dem Verfahren gesichtet.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise