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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 7/2017

01.07.2017 | Immunologic/Diagnostic Tests in Allergy (M Chapman and A Pomés, Section Editors)

Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy

verfasst von: Zbigniew Bartuzi, Renata Rodrigues Cocco, Antonella Muraro, Anna Nowak-Węgrzyn

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 7/2017

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Abstract

Purpose of Review

We sought to describe the available evidence supporting the utilization of the molecular allergen analysis (MAA) for diagnosis and management of cow milk protein allergy (CMPA).

Recent Findings

Cow milk proteins are among the most common food allergens in IgE- and non-IgE-mediated food allergic disorders in children. Most individuals with CMPA are sensitized to both caseins and whey proteins. Caseins are more resistant to high temperatures compared to whey proteins.

Summary

MAA is not superior to the conventional diagnostic tests based on the whole allergen extracts for diagnosis of CMPA. However, MAA can be useful in diagnosing tolerance to extensively heated milk proteins in baked foods. Children with CMPA and high levels of casein IgE are less likely to tolerate baked milk compared to children with low levels of casein IgE. Specific IgE-binding patterns to casein and betalactoglobulin peptides may predict the natural course of CMPA and differentiate subjects who are more likely to develop CMPA at a younger age versus those with a more persistent CMPA. Specific IgE-binding patterns to casein and beta-lactoglobulin peptides may also predict response to milk OITand identify patientsmost likely to benefit fromOIT.
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Metadaten
Titel
Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy
verfasst von
Zbigniew Bartuzi
Renata Rodrigues Cocco
Antonella Muraro
Anna Nowak-Węgrzyn
Publikationsdatum
01.07.2017
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 7/2017
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-017-0716-z

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