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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 12/2017

01.12.2017 | Allergic Skin Diseases (L Fonacier, Section Editor)

Pathomechanisms of Contact Sensitization

verfasst von: Philipp R. Esser, Stefan F. Martin

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 12/2017

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Abstract

Contact sensitization is the initial process involved in the development of an allergic reaction to xenobiotic environmental substances. Here, we briefly describe the differences between irritant and allergic contact dermatitis. Then, we highlight the essential steps involved in the development of an ACD reaction, i.e., the protein binding of haptens, genetic factors influencing the penetration of sensitizers into the skin, the different mechanisms driving the initial development of an inflammatory cytokine micromilieu enabling the full maturation of dendritic cells, the role of pre- and pro-haptens, antigen presentation and T cell activation via MHC and CD1 molecules, dendritic cell (DC) migration, and potential LC contribution as well as the different T cell subsets involved in ACD. In addition, we discuss the latest publications regarding factors that might influence the sensitizing potential such as repeated sensitizer application, penetration enhancers, humidity of the skin, microbiota, Tregs, and phthalates. Last but not least, we briefly touch upon novel targets for drug development that might serve as treatment options for ACD.
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Metadaten
Titel
Pathomechanisms of Contact Sensitization
verfasst von
Philipp R. Esser
Stefan F. Martin
Publikationsdatum
01.12.2017
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 12/2017
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-017-0752-8

Weitere Artikel der Ausgabe 12/2017

Current Allergy and Asthma Reports 12/2017 Zur Ausgabe

Basic and Applied Science (I Lewkowich, Section Editor)

Endoplasmic Reticulum Stress and Allergic Diseases

Food Allergy (T Green, Section Editor)

Non-IgE-mediated Adverse Food Reactions

Pediatric Allergy and Immunology (W Dolen, Section Editor)

Risk Factors in Preschool Children for Predicting Asthma During the Preschool Age and the Early School Age: a Systematic Review and Meta-Analysis

Basic and Applied Science (I Lewkowich, Section Editor)

Staphylococcal Biofilms in Atopic Dermatitis

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