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Erschienen in:

01.10.2012 | Transplantation (A Pileggi, Section Editor)

Transplantation of the Pancreas

verfasst von: Ugo Boggi, Fabio Vistoli, Francesca Maria Egidi, Piero Marchetti, Nelide De Lio, Vittorio Perrone, Fabio Caniglia, Stefano Signori, Massimiliano Barsotti, Matteo Bernini, Margherita Occhipinti, Daniele Focosi, Gabriella Amorese

Erschienen in: Current Diabetes Reports | Ausgabe 5/2012

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Abstract

Pancreas transplantation consistently induces insulin-independence in beta-cell-penic diabetic patients, but at the cost of major surgery and life-long immunosuppression. One year after grafting, patient survival rate now exceeds 95 % across recipient categories, while insulin independence is maintained in some 85 % of simultaneous pancreas and kidney recipients and in nearly 80 % of solitary pancreas transplant recipients. The half-life of the pancreas graft currently averages 16.7 years, being the longest among extrarenal grafts, and substantially matching the one of renal grafts from deceased donors. The difference between expected (100 %) and actual insulin-independence rate is mostly explained by technical failure in the postoperative phase, and rejection in the long-term period. Death with a functioning graft remains a further major issue, especially in uremic patients who have undergone prolonged periods of dialysis. Refinements in graft preservation, surgical techniques, immunosuppression, and prophylactic treatments are expected to further improve the results of pancreas transplantation.

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Titel: Transplantation of the Pancreas
verfasst von: Ugo Boggi
Fabio Vistoli
Francesca Maria Egidi
Piero Marchetti
Nelide De Lio
Vittorio Perrone
Fabio Caniglia
Stefano Signori
Massimiliano Barsotti
Matteo Bernini
Margherita Occhipinti
Daniele Focosi
Gabriella Amorese
Publikationsdatum: 01.10.2012
Verlag: Current Science Inc.
Erschienen in: Current Diabetes Reports / Ausgabe 5/2012
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-012-0293-4

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