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Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 3/2014

01.03.2014 | Sleep (M Thorpy, M Billiard, Section Editors)

Epigenetics of Sleep and Chronobiology

verfasst von: Irfan A. Qureshi, Mark F. Mehler

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 3/2014

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Abstract

The circadian clock choreographs fundamental biological rhythms. This system is comprised of the master circadian pacemaker in the suprachiasmatic nucleus and associated pacemakers in other tissues that coordinate complex physiological processes and behaviors, such as sleep, feeding, and metabolism. The molecular circuitry that underlies these clocks and orchestrates circadian gene expression has been the focus of intensive investigation, and it is becoming clear that epigenetic factors are highly integrated into these networks. In this review, we draw attention to the fundamental roles played by epigenetic mechanisms in transcriptional and post-transcriptional regulation within the circadian clock system. We also highlight how alterations in epigenetic factors and mechanisms are being linked with sleep-wake disorders. These observations provide important insights into the pathogenesis and potential treatment of these disorders and implicate epigenetic deregulation in the significant but poorly understood interconnections now emerging between circadian processes and neurodegeneration, metabolic diseases, cancer, and aging.
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Metadaten
Titel
Epigenetics of Sleep and Chronobiology
verfasst von
Irfan A. Qureshi
Mark F. Mehler
Publikationsdatum
01.03.2014
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 3/2014
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-013-0432-6

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