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Current Oncology Reports

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01.02.2012 | Breast Cancer (KR Fox, Section Editor)

Bevacizumab in the Treatment of Metastatic Breast Cancer: Friend or Foe?

verfasst von: Alberto J. Montero, Mauricio Escobar, Gilberto Lopes, Stefan Glück, Charles Vogel

Erschienen in: Current Oncology Reports | Ausgabe 1/2012

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Abstract

Metastatic breast cancer (MBC) is a major cause of death among women worldwide. Progress has been made in treating MBC with the advent of anti-estrogen therapies, potent cytotoxic agents, and monoclonal antibodies. Bevacizumab is a monoclonal antibody against circulating vascular endothelial growth factor (VEGF), which was approved in 2008 by the US Food and Drug Administration (FDA), for first-line treatment of HER-2 negative MBC in combination with paclitaxel. The FDA then reversed this decision in December 2010 by recommending removal of the MBC indication from bevacizumab, citing primarily safety concerns, and that these risks did not outweigh the ability of bevacizumab to significantly prolong progression-free survival. This decision was unexpected in the oncology community and remains controversial. This review looks at all available phase 3 data with bevacizumab in the MBC setting to determine whether the data support this decision by the FDA, and discusses the future of bevacizumab in breast cancer.

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Titel: Bevacizumab in the Treatment of Metastatic Breast Cancer: Friend or Foe?
verfasst von: Alberto J. Montero
Mauricio Escobar
Gilberto Lopes
Stefan Glück
Charles Vogel
Publikationsdatum: 01.02.2012
Verlag: Current Science Inc.
Erschienen in: Current Oncology Reports / Ausgabe 1/2012
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-011-0202-z

Springer Medizin

Bevacizumab in the Treatment of Metastatic Breast Cancer: Friend or Foe?

Abstract

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Viel pflanzliche Nahrung, seltener Prostata-Ca.-Progression

Alter verschlechtert Prognose bei Endometriumkarzinom

Update Onkologie

Springer Medizin

Abstract

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