Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 3/2013

01.09.2013 | Nutrition and Lifestyle in Osteoporosis (S Ferrari, Section Editor)

Polyunsaturated Fatty Acids and Their Relation with Bone and Muscle Health in Adults

verfasst von: Kelsey M. Mangano, Shivani Sahni, Jane E. Kerstetter, Anne M. Kenny, Marian T. Hannan

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Age-related bone and muscle loss are major public health problems. Investigational therapies to reduce these losses include anti-inflammatory dietary supplementations, such as polyunsaturated fatty acids (PUFA). Surprisingly, this topic has received little attention in the osteoporosis community. Recent research highlights the role of PUFA in inflammatory regulation of bone remodeling via cellular pathways. Emerging research suggests significant roles for PUFA in reducing bone and muscle loss with aging; however, findings are conflicted for PUFA and fracture risk. Limited studies suggest a relation between higher omega-3 FA and better muscle/bone in older adults. This review highlights new research since 2008 and synthesizes our current understanding of PUFA in relation to bone and muscle. Across study designs, evidence indicates that PUFA has positive effects upon bone. As data are sparse, future clinical trials and prospective studies are important to determine the long term benefits of PUFA supplementation upon bone and muscle outcomes.
Literatur
1.
Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet. 2011;377(9773):1276–87.PubMedCrossRef
2.
US Department of Health and Human Services. Bone health and osteoporosis: a report of the Surgeon General. Rockville, MD; 2004.
3.
Leibson CL, Tosteson AN, Gabriel SE, et al. Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc. 2002;50(10):1644–50.PubMedCrossRef
4.
Gillette-Guyonnet S, Nourhashemi F, Lauque S, et al. Body composition and osteoporosis in elderly women. Gerontology. 2000;46(4):189–93.PubMedCrossRef
5.
Iannuzzi-Sucich M, Prestwood M, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci. 2002;57(12):M772–7.PubMedCrossRef
6.
• Salari P, Rezaie A, Larijani B, et al. A systematic review of the impact of n-3 fatty acids in bone health and osteoporosis. Med Sci Monit. 2008;14(3):RA37–44. Most recent review previous to the current article on PUFA and bone health in humans.PubMed
7.
• Kruger MC, Coetzee M, Haag M, et al. Long-chain polyunsaturated fatty acids: selected mechanisms of action on bone. Prog Lipid Res. 2010;49(4):438–49. This comprehensive review highlights important biological mechanisms of action PUFA have on bone metabolism.PubMedCrossRef
8.
9.
Maurin AC, Chavassieux PM, Meunier PJ. Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. Calcif Tissue Int. 2005;76(5):385–92.PubMedCrossRef
10.
LeBlanc CJ, Horohov DW, Bauer JE, et al. Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. Am J Vet Res. 2008;69(4):486–93.PubMedCrossRef
11.
Priante G, Bordin L, Musacchio E, et al. Fatty acids and cytokine mRNA expression in human osteoblastic cells: a specific effect of arachidonic acid. Clin Sci (Lond). 2002;102(4):403–9.PubMedCrossRef
12.
Kang JX, Wang J, Wu L, et al. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004;427(6974):504.PubMedCrossRef
13.
Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006;83(6 Suppl):1505S–19S.PubMed
14.
Rahman MM, Bhattacharya A, Banu J, et al. Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis. J Cell Mol Med. 2009;13(8B):1833–44.PubMedCrossRef
15.
Shen CL, Yeh JK, Rasty J, et al. Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats. Br J Nutr. 2006;95(3):462–8.PubMedCrossRef
16.
Watkins BA, Li Y, Lippman HE, Feng S. Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism. Prostaglandins Leukot Essent Fatty Acids. 2003;68(6):387–98.PubMedCrossRef
17.
Sun D, Krishnan A, Zaman K, et al. Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J Bone Miner Res. 2003;18(7):1206–16.PubMedCrossRef
18.
Bonnet N, Ferrari SL. Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. J Nutr Biochem. 2011;22(7):665–72.PubMedCrossRef
19.
Hayashi N, Tashiro T, Yamamori H, et al. Effect of intravenous omega-6 and omega-3 fat emulsions on nitrogen retention and protein kinetics in burned rats. Nutrition. 1999;15(2):135–9.PubMedCrossRef
20.
van Norren K, Kegler D, Argiles JM, et al. Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice. Br J Cancer. 2009;100(5):713–22.PubMedCrossRef
21.
•• Smith GI, Atherton P, Reeds DN, et al. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr. 2011;93(2):402–12. This citation is one of few controlled, clinical trials that shows evidence in support of DIETARY INTERVENTIONS in older adults to promote muscle protein synthesis and elucidates a potential mechanism of action.PubMedCrossRef
22.
Smith GI, Atherton P, Reeds DN, et al. Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women. Clin Sci (Lond). 2011;121(6):267–78.PubMedCrossRef
23.
Gingras AA, White PJ, Chouinard PY, et al. Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity. J Physiol. 2007;579(Pt 1):269–84.PubMedCrossRef
24.
Rousseau JH, Kleppinger A, Kenny AM. Self-reported dietary intake of omega-3 fatty acids and association with bone and lower extremity function. J Am Geriatr Soc. 2009;57(10):1781–8.PubMedCrossRef
25.
Jarvinen R, Tuppurainen M, Erkkila AT, et al. Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. Eur J Clin Nutr. 2011;66(4):496–503.
26.
• Farina EK, Kiel DP, Roubenoff R, et al. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr. 2011;93(5):1142–51. This reference is one of few which examines interactions between individual PUFA and their association with bone mineral density.PubMedCrossRef
27.
•• Farina EK, Kiel DP, Roubenoff R, et al. Plasma phosphatidylcholine concentrations of polyunsaturated fatty acids are differentially associated with hip bone mineral density and hip fracture in older adults: the Framingham Osteoporosis Study. J Bone Miner Res. 2012;27(5):1222–30. This important work is starting to unravel the complexities of individual types of PUFA that may have implications for bone loss and fracture.PubMedCrossRef
28.
Virtanen JK, Mozaffarian D, Cauley JA, et al. Fish consumption, bone mineral density, and risk of hip fracture among older adults: the cardiovascular health study. J Bone Miner Res. 2010;25(9):1972–9.PubMedCrossRef
29.
Weiss LA, Barrett-Connor E, von Muhlen D. Ratio of n-6 to n-3 fatty acids and bone mineral density in older adults: the Rancho Bernardo Study. Am J Clin Nutr. 2005;81(4):934–8.PubMed
30.
Ferrucci L, Cherubini A, Bandinelli S, et al. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab. 2006;91(2):439–46.PubMedCrossRef
31.
Reinders I, Virtanen JK, Brouwer IA, Tuomainen TP. Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. Eur J Clin Nutr. 2012;66(6):736–41.PubMedCrossRef
32.
Lappe J, Kunz I, Bendik I, et al. Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study. Eur J Nutr. 2013;52(1):203–15.PubMedCrossRef
33.
Martin-Bautista E, Munoz-Torres M, Fonolla J, et al. Improvement of bone formation biomarkers after 1-year consumption with milk fortified with eicosapentaenoic acid, docosahexaenoic acid, oleic acid, and selected vitamins. Nutr Res. 2010;30(5):320–6.PubMedCrossRef
34.
Salari Sharif P, Asalforoush M, Ameri F, et al. The effect of n-3 fatty acids on bone biomarkers in Iranian postmenopausal osteoporotic women: a randomized clinical trial. Age (Dordr). 2010;32(2):179–86.CrossRef
35.
• Farina EK, Kiel DP, Roubenoff R, et al. Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. J Nutr. 2011;141(6):1146–53. This reference is one of few which examines interactions between individual PUFA and their association with hip fracture risk.PubMedCrossRef
36.
Orchard TS, Cauley JA, Frank GC, et al. Fatty acid consumption and risk of fracture in the Women's Health Initiative. Am J Clin Nutr. 2010;92(6):1452–60.PubMedCrossRef
37.
Virtanen JK, Mozaffarian D, WillettWC, Feskanich D. Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. Osteoporos Int. 2012;23(11):2615–24.
38.
Fan F, Xue WQ, Wu BH, et al. Higher fish intake is associated with a lower risk of hip fractures in Chinese men and women: a matched case–control study. PLoS One. 2013;8(2):e56849.PubMedCrossRef
39.
Chen YM, Ho SC, Lam SS. Higher sea fish intake is associated with greater bone mass and lower osteoporosis risk in postmenopausal Chinese women. Osteoporos Int. 2010;21(6):939–46.PubMedCrossRef
40.
Shamliyan T, Talley KM, Ramakrishnan R, Kane RL. Association of frailty with survival: a systematic literature review. Ageing Res Rev. 2012;12(2):719–36.
41.
Murphy RA, Mourtzakis M, Chu QS, et al. Skeletal muscle depletion is associated with reduced plasma (n-3) fatty acids in non-small cell lung cancer patients. J Nutr. 2010;140(9):1602–6.PubMedCrossRef
42.
Ryan AM, Reynolds JV, Healy L, et al. Enteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery: results of a double-blinded randomized controlled trial. Ann Surg. 2009;249(3):355–63.PubMedCrossRef
43.
Takayama M, Arai Y, Sasaki S, et al. Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. J Nutr Health Aging. 2013;17(1):82–9.PubMedCrossRef
44.
Hutchins-Wiese HL, Kleppinger A, Annis K, et al. The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women. J Nutr Health Aging. 2013;17(1):76–80.PubMedCrossRef
45.
Kris-Etherton PM, Taylor DS, Yu-Poth S, et al. Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr. 2000;71(1 Suppl):179S–88S.PubMed
46.
Trumbo P, Schlicker S, Yates AA, et al. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc. 2002;102(11):1621–30.PubMedCrossRef
47.
Dietary Guidelines Committee. Report of the dietary guidelines advisory committee on the dietary guidelines for Americans. Washington: U.S. Department of Agriculture; 2005.
48.
World Health Organization. Population nutrient intake goals for preventing diet-related chronic diseases. Geneva, Switzerland; 2003.
49.
Simopoulos AP, Leaf A, Salem Jr N. Workshop statement on the essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2000;63(3):119–21.PubMedCrossRef
50.
Welch AA, Shakya-Shrestha S, Lentjes MA, et al. Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of alpha-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. Am J Clin Nutr. 2010;92(5):1040–51.PubMedCrossRef
51.
Meyer BJ, Mann NJ, Lewis JL, et al. Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids. 2003;38(4):391–8.PubMedCrossRef
52.
Kris-Etherton PM, Harris WS, Appel LJ. American Heart Association. Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106(21):2747–57.PubMedCrossRef
53.
Arab L. Biomarkers of fat and fatty acid intake. J Nutr. 2003;133 Suppl 3:925S–32S.PubMed
54.
Metadaten
Titel
Polyunsaturated Fatty Acids and Their Relation with Bone and Muscle Health in Adults
verfasst von
Kelsey M. Mangano
Shivani Sahni
Jane E. Kerstetter
Anne M. Kenny
Marian T. Hannan
Publikationsdatum
01.09.2013
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 3/2013
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-013-0149-0

Weitere Artikel der Ausgabe 3/2013

Current Osteoporosis Reports 3/2013 Zur Ausgabe

Nutrition and Lifestyle in Osteoporosis (S Ferrari, Section Editor)

Vitamin B12, Folic Acid, and Bone

Hot Topic

Advanced CT based In Vivo Methods for the Assessment of Bone Density, Structure, and Strength

Future Therapeutics (P Miller, Section Editor)

Osteoporosis and Cancer

Evaluation and Management (M Kleerekoper, Section Editor)

The Women’s Health Initiative: Hormone Therapy and Calcium/Vitamin D Supplementation Trials

Evaluation and Management (M Kleerekoper, Section Editor)

Atypical Femoral fractures: A Review of the Literature

Nutrition and Lifestyle in Osteoporosis (S Ferrari, Section Editor)

Influence of Hormonal Appetite and Energy Regulators on Bone

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise