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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 3/2017

11.05.2017 | Kidney and Bone (S Moe and I Salusky, Section Editors)

Renal Osteodystrophy or Kidney-Induced Osteoporosis?

verfasst von: Sharon M. Moe

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2017

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Abstract

Purpose of Review

Chronic kidney disease (CKD) affects nearly 10% of the population. The incidence of fractures in population studies demonstrate an increase with worsening stages of kidney disease suggesting specific CKD related causes of fracture.

Recent Findings

The increase in fractures with CKD most likely represents disordered bone quality due to the abnormal bone remodeling from renal osteodystrophy. There is also an increase in fractures with age in patients with CKD, suggesting that patients with CKD also have many fracture risk factors common to patients without known CKD. Osteoporosis is defined by the National Institutes of Health as “A skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Bone strength reflects the integration of two main features: bone quantity and bone quality.”

Summary

Thus, CKD-related fractures can be considered a type of osteoporosis—where the bone quality is additionally impaired above that of age/hormonal-related osteoporosis. Perhaps using the term CKD-induced osteoporosis, similar to steroid-induced osteoporosis, will allow patients with CKD to be studied in trials investigating therapeutic agents. In this series, we will examine how CKD-induced osteoporosis may be diagnosed and treated.
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Metadaten
Titel
Renal Osteodystrophy or Kidney-Induced Osteoporosis?
verfasst von
Sharon M. Moe
Publikationsdatum
11.05.2017
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 3/2017
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-017-0364-1

Weitere Artikel der Ausgabe 3/2017

Current Osteoporosis Reports 3/2017 Zur Ausgabe

Kidney and Bone (S Moe and I Salusky, Section Editors)

Treatment of Pediatric Chronic Kidney Disease-Mineral and Bone Disorder

Therapeutics and Medical Management (S Jan de Beur and B Clarke, Section editors)

Exploiting the WNT Signaling Pathway for Clinical Purposes

Osteoimmunology (M Nakamura and M Humphrey, Section Editors)

TNF and Bone Remodeling

Kidney and Bone (S Moe and I Salusky, Section Editors)

Biomarkers Predicting Bone Turnover in the Setting of CKD

Osteoimmunology (M Nakamura and M Humphrey, Section Editors)

T Regulatory Cells in Bone Remodelling

Kidney and Bone (S Moe and I Salusky, Section Editors)

Calcium Balance in Chronic Kidney Disease

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