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Current Psychiatry Reports

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01.11.2013 | Substance Use and Related Disorders (JR McKay, Section Editor)

Genetic Influences on the Development of Alcoholism

verfasst von: Mary-Anne Enoch

Erschienen in: Current Psychiatry Reports | Ausgabe 11/2013

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Abstract

Alcoholism has a substantial heritability yet the detection of specific genetic influences has largely proved elusive. The strongest findings are with genes encoding alcohol metabolizing enzymes. A few candidate genes such as GABRA2 have shown robust associations with alcoholism. Moreover, it has become apparent that variants in stress-related genes such as CRHR1, may only confer risk in individuals exposed to trauma, particularly in early life. Over the past decade there have been tremendous advances in large scale SNP genotyping technologies allowing for genome-wide associations studies (GWAS). As a result, it is now recognized that genetic risk for alcoholism is likely to be due to common variants in very many genes, each of small effect, although rare variants with large effects might also play a role. This has resulted in a paradigm shift away from gene centric studies toward analyses of gene interactions and gene networks within biologically relevant pathways.

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Titel: Genetic Influences on the Development of Alcoholism
verfasst von: Mary-Anne Enoch
Publikationsdatum: 01.11.2013
Verlag: Springer US
Erschienen in: Current Psychiatry Reports / Ausgabe 11/2013
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-013-0412-1

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