Introduction
Challenges of Depression Genetics
Study | Year | Total N | Cases | Controls | Cohort | Ancestry | Depression phenotype | GWAS hits | Putative genes |
h
2
SNP (s.e.) |
---|---|---|---|---|---|---|---|---|---|---|
PGC [4] | 2013 | 18,759 | 9240 | 9519 | European | Lifetime MDD established using structured clinical interviews | 0 | – | 0.21 (0.021)a
| |
CHARGE [5] | 2013 | 34,549 | 34,549 | European | Depressive symptoms in past weeks assessed by questionnaires | 0 | – | Not calculated | ||
CONVERGE [20•] | 2015 | 10,640 | 5303 | 5337 | East Asian | Recurrent MDD in women | 2 |
SIRT1, LHPP
| 0.21 (0.030) | |
SSGAC [24•] | 2016 | 180,866 | 16,471 | 58,835 | 105,739 | European | Depressive symptoms in past 2 weeks assessed by 2 questions; lifetime MDD | 2 |
KSR2, DCC
| 0.04 (0.004) |
23andMe [22•] | 2016 | 307,354 | 121,380 | 338,101 | European | Self-report of diagnosis or treatment for major depression | 17 |
TMEM161B-MEF2C, VRK2, L3MBTL2, NEGR1, RERE, HACE1-LIN28B, SORCS3, OLFM4, PAX5, MEIS2-TMCO5A, intergenic, RSRC1-MLF1, intergenic, SLC6A15, NEGR1, KIAA0020-RFX3
| 0.06b
| |
CHARGE + PGC [32•] | 2016 | 70,017 | 9240 | 9519 | 51,258 | European | Depressive symptoms in past weeks assessed by questionnaires; lifetime MDD | 1 |
FHIT
| 0.30 (0.040) |