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Current Rheumatology Reports

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01.08.2012 | PSORIATIC ARTHRITIS (O FITZGERALD AND P HELLIWELL, SECTION EDITORS)

What Have Genome-Wide Studies Told Us About Psoriatic Arthritis?

verfasst von: James Bluett, Anne Barton

Erschienen in: Current Rheumatology Reports | Ausgabe 4/2012

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Abstract

There is convincing evidence to suggest a strong genetic component to psoriatic arthritis (PsA), with studies reporting a 40-fold risk to first-degree relatives of patients with disease. However, compared with rheumatoid arthritis, our understanding of the genetic etiology of PsA is less well-developed. Only three modestly sized genome-wide association studies of PsA have been undertaken to date, but they have identified the HLA-C region, IL12B, TRAF3IP2, and FBXL19 genes as being associated with PsA susceptibility. Results of genome-wide association studies of psoriasis and rheumatoid arthritis have been used to identify candidate genes for subsequent testing in PsA and have led to the identification of additional susceptibility factors for PsA. Most show overlap with psoriasis, whereas the overlap with rheumatoid arthritis is less pronounced. However, two loci show strong evidence for association with PsA but not psoriasis: HLA-B27 and the IL-13 gene locus.

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Titel: What Have Genome-Wide Studies Told Us About Psoriatic Arthritis?
verfasst von: James Bluett
Anne Barton
Publikationsdatum: 01.08.2012
Verlag: Current Science Inc.
Erschienen in: Current Rheumatology Reports / Ausgabe 4/2012
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-012-0255-5

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