nach oben

Current Rheumatology Reports

Erschienen in:

01.10.2012 | SERONEGATIVE ARTHRITIS (MA KHAN, SECTION EDITOR)

Juvenile Spondyloarthropathies

verfasst von: R. Hal Scofield, Andrea L. Sestak

Erschienen in: Current Rheumatology Reports | Ausgabe 5/2012

Einloggen, um Zugang zu erhalten

Abstract

Spondyloarthropathy (or spondyloarthritis) can begin in childhood (defined as individuals less than 16 years of age). These diseases are distinct in childhood, when compared with adult-onset disease. Because of overlapping features, especially sacroiliac joint involvement, diagnostic difficulty may arise from Behcet’s disease, as well as familial Mediterranean fever. Despite advances in diagnostic techniques such as magnetic resonance imaging, the diagnosis of juvenile spondyloarthropathy may still be delayed many years from the onset of symptoms. Treatment of juvenile spondyloarthropathy has advanced rapidly in the last several years, with increasing evidence that agents targeting tumor necrosis factor are effective. These agents also have serious complications, including induction of other autoimmune diseases.

van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27:361–8.PubMedCrossRef

Dougados M, van der Linden S, Juhlin R, et al. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum. 1991;34:1218–27.PubMedCrossRef

• Colbert RA. Classification of juvenile spondyloarthritis: Enthesitis-related arthritis and beyond. Nat Rev Rheumatol. 2010;6:477–85. This article gives a concise summary of classification of juvenile spondyloarthropathy under the International League of Associations for Rheumatology classification of juvenile idiopathic arthritis. Both the good points and deficiencies are noted. PubMedCrossRef

Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31:390–2.PubMed

Horneff G, Burgos-Vargas R. Juvenile idiopathic arthritis. Subgroup characteristics and comparisons between rheumatoid arthritis–like subgroups and ankylosing spondylitis–like subgroups. Clin Exp Rheumatol. 2009;27:S131–8.PubMed

Sheerin KA, Giannini EH, Brewer Jr EJ, Barron KS. HLA-B27-associated arthropathy in childhood: long-term clinical and diagnostic outcome. Arthritis Rheum. 1988;31:1165–70.PubMedCrossRef

Flato B, Smerdel A, Johnston V, et al. The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. Arthritis Rheum. 2002;46:986–94.PubMedCrossRef

Burgos-Vargas R, Vazquez-Mellado J. The early clinical recognition of juvenile-onset ankylosing spondylitis and its differentiation from juvenile rheumatoid arthritis. Arthritis Rheum. 1995;38:835–44.PubMedCrossRef

Minden K, Niewerth M, Listing J, et al. Long-term outcome in patients with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46:2392–401.PubMedCrossRef

10.

•• Burgos-Vargas R. The assessment of the spondyloarthritis international society concept and criteria for the classification of axial spondyloarthritis and peripheral spondyloarthritis: a critical appraisal for the pediatric rheumatologist. Ped Rheumatol. 2012;10:14. Available at http://www.ped-rheum.com/content/10/1/14. This paper reviews the criteria for juvenile spondyloarthropathy proposed by the SpondyloArthritis International Society. This system groups all HLA-B27-related childhood arthritic disease together, with separate criteria for disease involving peripheral or axial joints. The author proposes that because of similar prognosis and treatment, juvenile spondyloarthropathies should be considered together as a single classification entity.

11.

Hofer M, Southwood TR. Classification of childhood arthritis. Best Prac Res Clin Rheumatol. 2002;16:379–96.

12.

Manners PJ, Bower C. Worldwide prevalence of juvenile arthritis why does it vary so much? J Rheumatol. 2002;29:1520–30.PubMed

13.

Gomez KS, Raza K, Jones SD, Kennedy LG, Calin A. Juvenile onset ankylosing spondylitis—more girls than we thought? J Rheumatol. 1997;24:735–7.PubMed

14.

Burgos-Vargas R, Vazquez-Mellado J, Pacheco-Tena C, Hernandez-Garduno A, Goycochea-Robles MV. A 26 week randomised, double blind, placebo controlled exploratory study of sulfasalazine in juvenile onset spondyloarthropathies. Ann Rheum Dis. 2002;61:941–2.PubMedCrossRef

15.

Wanders A, Heijde D, Landewe R, et al. Nonsteroidal antiinflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum. 2005;52:1756–65.PubMedCrossRef

16.

Homeff G, Burgos-Vargas R. TNF-alpha antagonists for the treatment of juvenile-onset spondyloarthritides. Clin Exp Rheumatol. 2002;20 Suppl 28:S137–42.PubMed

17.

Maghraoui AE, Tabache F, Bezza A, et al. A controlled study of sacroiliitis in Behcet's disease. Clin Rheumatol. 2001;20:189–91.PubMedCrossRef

18.

Radouane A, Oudghiri M, Chakib A, et al. HLA-B*27 allele associated to Behcet's disease and to anterior uveitis in Moroccan patients. Ann Biol Clin. 2011;69:419–24.

19.

Bettencourt A, Pereira C, Carvalho L, et al. New insights of HLA class I association to Behcet's disease in Portuguese patients. Tissue Antigens. 2008;72:379–82.PubMedCrossRef

20.

Kasifoglu T, Calisir C, Cansu DU, Korkmaz C. The frequency of sacroiliitis in familial Mediterranean fever and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis. Clin Rheumatol. 2009;28:41–6.PubMedCrossRef

21.

Cinar M, Dinc A, Simsek I, et al. The rate and significance of Mediterranean fever gene mutations in patients with ankylosing spondylitis: a three-month, longitudinal clinical study. Rheumatol Int. 2008;29:37–42.PubMedCrossRef

22.

Ozgocmen S, Ardicoglu O, Kamanli A, et al. Pattern of disease onset, diagnostic delay, and clinical features in juvenile onset and adult onset ankylosing spondylitis. J Rheumatol. 2009;36:2830–33.PubMedCrossRef

23.

Marks SH, Barnett M, Calin A. A case–control study of juvenile- and adult-onset ankylosing spondylitis. J Rheumatol. 1982;9:739–41.PubMed

24.

Stone M, Warren RW, Bruckel J, et al. Juvenile-onset ankylosing spondylitis is associated with worse functional outcomes than adult-onset ankylosing spondylitis. Arthritis Rheum. 2005;53:445–51.PubMedCrossRef

25.

• Maksymowych WP. MRI in ankylosing spondylitis. Curr Opin Rheumatol. 2009;21:313–7. This paper thoroughly reviews the advances made in using MRI in ankylosing spondylitis, but there are no data about children. PubMedCrossRef

26.

Madsen KB, Schiottz-Christensen B, Jurik AG. Prognostic significance of magnetic resonance imaging changes of the sacroiliac joints in spondyloarthritis—a followup study. J Rheumatol. 2010;37:1718–27.PubMedCrossRef

27.

Bochkova AG, Levshakova AV, Bunchuk NV, Braun J. Spinal inflammation lesions as detected by magnetic resonance imaging in patients with early ankylosing spondylitis are more often observed in posterior structures of the spine. Rheumatology. 2010;49:749–55.PubMedCrossRef

28.

Yilmaz MH, Ozbayrak M, Kasapcopur O, et al. Pelvic MRI findings of juvenile-onset ankylosing spondylitis. Clin Rheumatol. 2010;29:1007–13.PubMedCrossRef

29.

Bollow M, Biedermann T, Kannenberg J, et al. Use of dynamic magnetic resonance imaging to detect sacroiliitis in HLA-B27 positive and negative children with juvenile arthritides. J Rheumatol. 1998;25:556–64.PubMed

30.

• Stoll ML, Bhore R, Dempsey-Robertson M, Punaro M. Spondyloarthritis in a pediatric population: risk factors for sacroiliitis. J Rheumatol. 2010;37:2402–8. This interesting study from the Texas Scottish Rite Hospital for Children and the University of Texas Southwestern studied a large cohort of juvenile spondyloarthropathy. Sacroiliitis was found in about half of 143 patients. Hip disease predicted sacroiliitis, while dactylitis was associated with an absence of sacroiliitis. PubMedCrossRef

31.

Spadaro A, Iagnocco A, Baccano G, et al. Sonographic-detected joint effusion compared to physical examination in the assessment of sacroiliac joints in spondyloarthritis. Ann Rheum Dis. 2009;68:1559–63.PubMedCrossRef

32.

Williamson L, Dockerty JL, Dalbeth N, et al. Clinical assessment of sacroiliitis and HLA-B27 are poor predictors of sacroiliitis diagnosed by magnetic resonance imaging in psoriatic arthritis. Rheumatology. 2004;43:85–8.PubMedCrossRef

33.

• Stoll ML, Nigrovic PA, Gotte AC, Punaro M. Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. Clin Exp Rheumatol. 2011;29:582–8. This paper that studies a large group of patients continues the story that psoriatic-related juvenile arthritis is a distinct entity from ologoarticular juvenile idiopathic arthritis. PubMed

34.

• Stoll ML, Punaro M. Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. Curr Opin Rheumatol. 2011;23:437–43. A concise review of the clinical heterogeneity of juvenile psoriatic arthritis. PubMedCrossRef

35.

• Sieper J. Spondyloarthropathies in 2010: new insights into therapy-TNF blockade and beyond. Nat Rev Rheumatol. 2011;7:78–80. A concise review of the role of anti-TNF therapy in spondyloarthritis PubMedCrossRef

36.

• Otten MH, Prince FH, Twilt M, et al. Tumor necrosis factor–blocking agents for children with enthesitis–related arthritis–data from the Dutch arthritis and biologicals in children register, 1999–2010. J Rheumatol. 2011;38:2258–63. Enthesis-related juvenile idiopathic arthritis responded well to etanercept.PubMedCrossRef

37.

•• Otten MH, Prince FH, Armbrust W, et al. Factors associated with treatment response to etanercept in juvenile idiopathic arthritis. JAMA. 2011;306:2340–7. This large ongoing prospective observational trial of biologics in JIA suggests that etanercept is highly efficacious in juvenile spondyloarthropathy. PubMedCrossRef

38.

Horneff G, De Bock F, Foeldvari I, et al. Safety and efficacy of combination of etanercept and methotrexate compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA Registry. Ann Rheum Dis. 2009;68:519–25.PubMedCrossRef

39.

• Dougados M, Combe B, Braun J, et al. A randomised, multicenter, double-blind, placebo-controlled trial of etanercept in adults with refractory heel enthesitis in spondyloarthritis: the HEEL trial. Ann Rheum Dis. 2010;69:1430–5. High-quality evidence in the form of a randomized, double-blind, placebo-controlled trial, that anti-TNF is efficacious for Achilles’ tendon enthesitis. This evidence was obtained entirely in adult patients, however. PubMedCrossRef

40.

van der Heijde D, Landewe R, Einstein S, et al. Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis. Arthritis Rheum. 2008;58:3063–70.PubMedCrossRef

41.

•• Oen K, Duffy CM, Tse SM, et al. Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort. Arthritis Care Res. 2010;62:527–36. This is a study of a very large inception cohort of patients with juvenile idiopathic arthritis. CrossRef

42.

Hage CA, Bowyer S, Tarvin SE, et al. Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy. Clin Infect Dis. 2010;50:85–92.PubMedCrossRef

43.

Smith JA, Kauffman CA. Endemic fungal infections in patients receiving tumour necrosis factor-alpha inhibitor therapy. Drugs. 2009;69:1403–15.PubMedCrossRef

44.

Wetter DA, Davis MD. Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic. Mayo Clin Proc. 2009;84:979–84.PubMed

45.

• Solomon AJ, Spain RI, Kruer MC, Bourdette D. Inflammatory neurological disease in patients treated with tumor necrosis factor alpha inhibitors. Mult Scler. 2010;17:1472–87. A nice case series and review of the literature. CrossRef

46.

Tarkiainen M, Tynjala P, Vahasalo P, Lahdenne P. Occurrence of inflammatory bowel disease in four patients with juvenile idiopathic arthritis receiving etanercept or infliximab. Scand J Rheumatol. 2011;40:150–2.PubMed

47.

Gaddy JR, Khan ZZ, Chaser B, Scofield RH. Whipple's disease diagnosis following the use of TNF-a blockade. Rheumatology. 2012;51:946.PubMedCrossRef

48.

Kakkassery V, Mergler S, Pleyer U. Anti-TNF-alpha treatment: a possible promoter in endogenous uveitis? observational report on six patients: occurrence of uveitis following etanercept treatment. Curr Eye Res. 2010;35:751–6.PubMedCrossRef

Titel: Juvenile Spondyloarthropathies
verfasst von: R. Hal Scofield
Andrea L. Sestak
Publikationsdatum: 01.10.2012
Verlag: Current Science Inc.
Erschienen in: Current Rheumatology Reports / Ausgabe 5/2012
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-012-0273-3

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Reizdarmsyndrom: Diäten wirksamer als Medikamente

29.04.2024 Reizdarmsyndrom Nachrichten

Bei Reizdarmsyndrom scheinen Diäten, wie etwa die FODMAP-arme oder die kohlenhydratreduzierte Ernährung, effektiver als eine medikamentöse Therapie zu sein. Das hat eine Studie aus Schweden ergeben, die die drei Therapieoptionen im direkten Vergleich analysierte.

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2012

Lipid Paradox in Rheumatoid Arthritis: Changes With Rheumatoid Arthritis Therapies

Managing Macrophages in Rheumatoid Arthritis by Reform or Removal

Racial and Ethnic Disparities in Rheumatoid Arthritis

Current Concept of Spondyloarthritis: Special Emphasis on Early Referral and Diagnosis

Cardiovascular Disease and Rheumatoid Arthritis: An Update